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15 Feb 2024: The LMB is saddened to learn of the death of Samantha Skehel, who worked as Grants Manager in the Finance Team and later Technical Officer in the Lab Services and Purchasing Team. Since 2015, she has been based at the Isaac Newton Institute for

23 Feb 2024: We work on developing new instruments and methods for imaging biological molecules, (DNA, RNA and proteins), at atomic resolution. ... Using this new technology, we study the detailed mechanisms of biomolecules to understand how they function.

23 Feb 2024: In another line of research, we use experimental cryo-EM together with our own image processing developments to discover new protein structures. ... RELION-3: new tools for automated high-resolution cryo-EM structure determination.

26 Mar 2024: Delineating the molecular mechanisms that impart daily rhythms to our biology is therefore important for understanding human health and may provide new insights into the prevention and treatment of many diseases.

31 Jan 2024: Published on. 31 January, 2024. Jason Chin spoke to BBC’s Roland Pease about his group’s new EcORep orthogonal replication system that enables rapid protein evolution in E.coli and ... how it could help create new substances to be used in medicine &

29 Apr 2024: 2023: Finally, divisome core complex resolved. Cell division in the vast majority of bacteria depends on the synthesis of new cell wall peptidoglycan and is catalysed by the divisome.

23 Feb 2024: The machines that comprise this proteostasis network include the ribosome, which synthesizes new proteins, chaperones that help new proteins fold, and degradation factors that eliminate incorrect or damaged proteins. ... We expect that our results will

23 Feb 2024: Our broad goal is to understand how smell turns into behaviour in the fruit fly brain. We currently use a combination of genetic labelling and

13 Mar 2024: We also aim to use DMS to develop new force fields at different scales, such as implicit solvent or coarse-grained models, allowing larger systems to be simulated.

23 Feb 2024: Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and Amyotrophic Lateral Sclerosis (ALS)

23 Feb 2024: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Jan Löwe.

23 Feb 2024: Cryo-EM is rapidly evolving and we are developing new methods to help determine protein structures.

25 Mar 2024: Projects Main applications for October 2024 are now closed. The LMB exceptionally considers applications for research-only MPhil students provided they

2 Apr 2024: Search this website. Rising Talent Fellowship. The MRC Laboratory of Molecular Biology (LMB) is proud to launch a new three-year fully funded postdoctoral fellowship for scientists from Black heritage backgrounds. ... This Fellowship is a three-year

16 Feb 2024: Elucidating the molecular details of this pathway was therefore paramount and had the potential to reveal new therapeutic targets for treating cancer.

23 Feb 2024: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Philipp

12 Mar 2024: The brain works as an integrated whole. Animals interact with the world by combining inputs from their senses of vision, hearing, smell, taste, touch and

23 Feb 2024: Precise chromosome replication is essential for maintaining genome stability, yet the process itself is inherently risky. Duplex DNA must be transiently

18 Mar 2024: Ultimately, mycobacteria can cause granuloma breakdown by inducing programmed macrophage death, a step that further increases bacterial growth and promotes transmission to new hosts. ... Our findings have been borne out in humans and are informing new

5 Mar 2024: Molecular motors have critical roles in the trafficking of organelles, vesicles and macromolecules within the cytoplasm, and aberrant motor function is

14 Mar 2024: In an effort to better understand human brain development, we have developed a new model system, called cerebral organoids.

23 Feb 2024: Science News : Scientists have mapped an insect brain in greater detail than ever before. ... Sky News : First map of insect brain signals 'big step forward' in understanding thoughts.

23 Feb 2024: Cells are highly compartmentalized into numerous membrane-bound organelles. The membranes that define each organelle contain unique sets of embedded

22 Mar 2024: Thus, understanding their cell biology requires re-thinking some of our most basic assumptions (bilayers membranes) and the development of new research tools and methods (high-temperature live cell imaging).

23 Feb 2024: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Chris Tate

23 Feb 2024: Information transfer in the nervous system occurs at synapses, where presynaptic signals are interpreted by postsynaptic receptors. We study this process

1 Feb 2024: Design of the new building. In keeping with the original ethos of the LMB, the building has an open plan design with many communal areas to encourage interactions and discussions between ... The LMB has a number of initiatives to help employees save

23 Feb 2024: Our research is aimed at understanding the mechanisms and regulation of chromosome segregation in mitosis. During the cell cycle, accurate chromosome

23 Feb 2024: The ends of linear eukaryotic chromosomes are capped telomeres, an array of long telomeric repeat tracts (nin human) bound by telomeric protein factors.

14 Mar 2024: Andrew Travers started his Ph.D. at the LMB under the tutelage of the late John Smith in 1964. After this he took a couple of years out as a post-doc in

1 Feb 2024: In 2013, the LMB moved to a new, purpose-built building designed to deliver the right environment in which innovative medical research, translation and collaboration can flourish. ... Both new and established researchers are encouraged to utilise the

11 Mar 2024: Marta Shahbazi, Group Leader in the LMB’s Cell Biology Division, has been announced as one of the 2024 recipients in the Life Sciences category.

23 Feb 2024: Splicing of precursor messenger RNA (pre-mRNA) is a ubiquitous hallmark of gene expression in all eukaryotes. Within the cell, splicing occurs

23 Feb 2024: We are interested in cell autonomous innate immunity, i.e. in the ability of individual cells to defend themselves against infection. Cytosolic defence

13 Feb 2024: Neuronal circuits are the biological substrates for all aspects of brain function such as learning, memory, thought, speech and consciousness. The

22 Mar 2024: Molecular Immunity Unit Menna Clatworthy LMB Division - Molecular Immunity Unit The Clatworthy lab is interested in understanding how B cell activation

2 Feb 2024: Cell shape is adapted to function. Organelle shape and local membrane architectures are likewise optimised for the processes that take place on and within

10 Apr 2024: Emmanuel Derivery, Group Leader in the LMB’s Cell Biology Division, is the 2024 recipient of the British Society for Cell Biology’s Hooke Medal.

22 Mar 2024: Collaborations with the University of Cambridge LMB scientists from across the Divisions are also involved in various collaborations and initiatives with

6 Mar 2024: She has expanded understanding of the molecular mechanisms which drive amyloid formation, and has discovered several new avenues of research for the field. ... Ultimately, this could prove crucial in the design of new drugs to target different

23 Feb 2024: Asymmetric cell division is the process by which one cell divides into two daughter cells that have different fates. Asymmetric division is the hallmark

2 Apr 2024: As an aside, I’m exploring various tools to make new reporters of clock function which will help us get a better overall picture of what is going on inside a

23 Apr 2024: In the summer of 2017, Prof. Cai moved to the University of Manchester as the new chair professor in synthetic genomics. ... Recent research has taken advantage on new advances in high resolution imaging to study the remarkable polarisation that these

1 Feb 2024: The move to a new building in 2013 allowed the LMB to provide much improved facilities across the organisation for those with disabilities.

1 Feb 2024: Mechanistic understanding of these enzymes has the potential to open new therapeutic opportunities.

12 Mar 2024: reveal a large number of new factors required for organisation of cells by the microtubule motor dynein. ... Follow up studies of one of these factors, the RNA-binding protein SUGP1, provided a proof-of-principle of how the screen can lead to new

23 Feb 2024: The scheme is intended to facilitate knowledge and skill exchange between technical specialists and, to this end, Tina spent one week in the Flow Cytometry Facility at the LMB learning new ... goals, but also in taking part in public engagement or to

5 Apr 2024: C&EN discusses recent research using the nematode worm C. elegans to examine wireless brain communications using neuropeptides. They include research

23 Apr 2024: Congratulations to Clemens Plaschka, who has been elected as a new member of the Austrian Academy of Sciences’ (ÖAW) Young Academy.

9 Apr 2024: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Student