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23 Feb 2024: We have had a considerable degree of success in collaborating with artists and designers, and new projects are regularly planned. ... Working together with designers Rachel Wingfield and Mathias Gmachl, we explored new ways of representing the molecular

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. MBU researchers help discover a new therapeutic strategy for a common form of ALS and dementia.

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. mtDNA engineering. GENETIC MODIFICATION OF THE MITOCHONDRIAL GENOME. Figure | The general concepts of moving the biochemical threshold in mtDNA disease using mitochondrial genome engineering: selective

23 Feb 2024: intensive methods that are infeasible with larger models, as well as a teaching tool for those new to modelling and needing a small, manageable model on which to learn and experiment. ... A new representation of the respiratory chain and the proton

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Sotiria Tavoulari. Sotiria Tavoulari. Preferred first name: Roula. Biography. Dr Sotiria Tavoulari is a Senior Research Associate at the Mitochondrial Biology Unit, specialising in molecular mechanisms of

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Development of an alternative MtDNA mutator model for APOBEC1. Submitted by Penny Peck on Thu, 25/07/2019 - 00:00. Stochastic mutations in the mitochondrial genome (mtDNA) have been linked to many diseases

23 Feb 2024: We also are involved in identifying new opportunties for applications and translations of our research and in knowldege transfer.

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Federica De Lazzari. Federica De Lazzari. Biography. Dr Federica De Lazzari studied Molecular Biology (BSc and MSc cum laude) at the University of Padua (Italy) and successively entered the PhD programme

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Research grant awarded to Michal Minczuk and collaborators. Submitted by Penny Peck on Tue, 06/09/2022 - 14:07. Congratulations to Michal Minczuk, Pedro Pinheiro and their collaborators, who have been

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Protein methylation. PROTEIN METHYLATION. methylation-fig9_2016flat.png. Figure Participation of NDUFAF5 in the pathway of assembly of human complex I. Assembly factors associated stably with

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Complex I cryoEM. COMPLEX I cryoEM. Figure Left: Cryo-EM density map of mammalian complex I with the fourteen catalytic core subunits coloured, and the mammalian supernumerary subunits in transparent grey.

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Denis Lacabanne. Denis Lacabanne. Biography. Dr. Denis Lacabanne is a biochemist who graduated with a Bachelor's degree in 2012 and a Master's degree in Structural and Functional Biochemistry in 2014 from

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Mitochondria interact with the cell's nucleus in subtle ways previously unseen in humans. Submitted by Penny Peck on Fri, 24/05/2019 - 00:00. Results of a collaborative research study involving MBU

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. David Sabatini MD PhD delivers the 7th Annual Sir John Walker Lecture. Submitted by Penny Peck on Mon, 03/06/2019 - 00:00. The 7th Annual Sir John Walker Lecture, ‘Regulation of Growth and Metabolism’,

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. The biology of TLCD proteins. The biology of TLCD proteins. fig-biology_of_tlcd_proteins.png. Figure: Cartoon depiction of a phylogenetic tree of human TLC-domain containing proteins. The Tram-Lag-CLN8

23 Feb 2024: NGS is a constantly evolving technique, making it crucial to constantly develop new protocols both for the wet-lab aspect and for the analysis pipelines. ... Lindsey uses her expertise to advise group members how to design their NGS project and to

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Judy Hirst and Mike Murphy elected Fellows of the Academy of Medical Sciences. Submitted by Penny Peck on Tue, 07/05/2019 - 00:00. The Unit is delighted to announce that Judy Hirst and Mike Murphy have

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Mariangela Dionysopoulou. Mariangela Dionysopoulou. Biography. Dr. Mariangela Dionysopoulou studied Agricultural Biotechnology in Athens, Greece. She was honored with a scholarship from the Stavros

23 Feb 2024: For her final year project, she developed a new diagnostic technique to screen for Hereditary Spastic Paraplegia mutations, at IBMC (Porto).

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Reporting issues and concerns. We strongly believe that nobody should be subjected to discrimination, bullying, harassment or sexual assault while studying or working in the MBU, and fully support the

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. New discovery unveils how fumarate drives mitochondria to release their DNA through vesicles formation to induce innate immunity. ... Christian Frezza at the CECAD (University of Cologne, Germany) have

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Complex I mechanism. COMPLEX I MECHANISM. catalytic_mechanism-01.jpg. Figure Left: Schematic diagram showing the elements involved in enzymatic catalysis. Right: Schematic picture of a co-reconstituted

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Alvaro Sanchez-Martinez. Alvaro Sanchez-Martinez. Biography. Dr Alvaro Sanchez-Martinez studied biochemistry and molecular biology at Autonomous University of Madrid, Spain, before joining the PhD program

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Structure of F1-ATPase from the obligate anaerobe Fusobacterium nucleatum. Submitted by Penny Peck on Wed, 26/06/2019 - 00:00. Adenosine triphosphate (ATP), the fuel of life, is produced by a molecular

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Molecular animations of ATP synthase. MOLECULAR ANIMATIONS OF ATP SYNTHASE. A series of animations that we have made to illustrate the function and assembly of the mitochondrial ATP synthase. Research

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. MBU postdoctoral scientist develops ggplot2 graphics tutorial. Submitted by Penny Peck on Mon, 16/05/2022 - 14:20. Lyuba Bozhilova is a postdoctoral bioinfomatician at the MRC MBU, who also curates our

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Whitworth group research identifies an important PINK1/Parkin mitophagy regulator. Submitted by Penny Peck on Tue, 20/02/2024 - 13:30. Mitochondrial dysfunction is a key pathogenic driver of

23 Feb 2024: Mammals switch on UCP1 activity in brown fat tissue to protect against the cold and to maintain body temperature, especially in new-borns, when shivering as a protective measure has not

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Thiol Proteomics and Acylation. THIOL PROTEOMICS AND ACYLATION. Altering the redox state of cysteine residues on protein surfaces is an important response to environmental challenges. We have investigated

23 Feb 2024: Medicine), provides important new insights into the cell damage that occurs during heart attacks.

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Reflection on the past, present and future of mitochondrial genome engineering. Submitted by Penny Peck on Wed, 08/12/2021 - 12:58. In a review published in Nature Reviews Genetics, entitled The potential

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Biochemical society announces Judy Hirst as the Keilin Memorial Lecturer. Submitted by Penny Peck on Wed, 27/03/2019 - 00:00. The Biochemical Society has announced Professor Judy Hirst FRS as the next

23 Feb 2024: Thus, superoxide anions represent potential cellular targets for new drugs offering a novel therapeutic approach to cope with the progression of PD[6]. ... Superoxide radical dismutation as new therapeutic strategy in Parkinson's disease..

23 Feb 2024: This new work showed that malonate, an inhibitor of SDH could slow down succinate metabolism on reperfusion and prevent damage in models of heart attack.

23 Feb 2024: Understanding the connection between metabolism and signalling may reveal new insights into inflammatory and autoimmune disease processes, as well as identifying novel anti-inflammatory metabolic compounds and targets.

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Current Opinion in Structural Biology - Best Paper Award for Researchers in Judy Hirst's Group. Submitted by Penny Peck on Mon, 13/11/2023 - 14:23. A review authored by members of Professor Judy Hirst’s

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank. Submitted by Penny Peck on Mon, 17/05/2021 - 17:20. Published in Nature Genetics, a collaboration between Public Health and

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. Submitted by Penny Peck on Tue, 20/12/2022 - 16:09. Mitochondria are dynamic organelles that undergo membrane remodeling events

23 Feb 2024: Importantly, preventing this metabolism of succinate with a new type of drug prevents this damage and may help improve the outcome for transplant patients and increase the number of organs that ... the use of new drugs may improve the function and

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Mito warriors: scientists discover how T cell assassins reload their weapons to kill and kill again - new footage shows T cells hunting down and destroying ... They are also at the heart of new immunotherapies

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Professors Patrick Chinnery and John Walker to deliver the XIII Oon Lecture. Submitted by Penny Peck on Tue, 25/01/2022 - 14:39. Professors Patrick Chinnery and John Walker will deliver the XIII Oon

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Collaboration with Nigerian researchers evaluating the neuroprotective potential of natural products. Submitted by Penny Peck on Mon, 28/03/2022 - 16:09. As an alternative to expensive pharmaceuticals,

23 Feb 2024: A new international collaborative study published in Nature Communications from the labs of Dr Julien Prudent at the MRC Mitochondrial Biology Unit, University of Cambridge, UK, and Dr Sidong Huang at ... the Rosalind & Morris Goodman Cancer Research

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Identification of the substrate binding mechanism of the mitochondrial ADP/ATP carrier. Submitted by Penny Peck on Tue, 28/06/2022 - 17:57. The results of a research study carried out by members of the MBU

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Early data presented at The Champ Foundation's 3rd Pearson Syndrome Conference. Submitted by Penny Peck on Mon, 25/07/2022 - 12:05. On Saturday, 9 July 2022, Drs Michal Minczuk, leader of the MBU's

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Chromatin and Mitochondrial Disease. CHROMATIN AND MITOCHONDRIAL DISEASE. research_theme_2-jelle-530.jpg. There is a constant interaction between mitochondria and the nucleus, with changes in each

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Role of cardiolipin in mitochondrial carriers. ROLE OF CARDIOLIPIN IN MITOCHONDRIAL CARRIERS. All mitochondrial carriers are likely to have three tightly bound cardiolipin molecules, which are important

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Substrate binding and proton coupling. SUBSTRATE BINDING AND PROTON COUPLING. In 2006, we identified the substrate binding site of mitochondrial carriers, consisting of three major contact points, which

23 Feb 2024: The enigma of an interconnected mitochondrial reticulum: new insights into mitochondrial fusion.

23 Feb 2024: Search site. MRC Mitochondrial Biology Unit. Associated Research Groups. Horvath Group. The Horvath Laboratory is a research group dedicated to improving the understanding of genetic neurological conditions, with a focus on mitochondrial and