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Julian Gough wins Academic Entrepreneur of the Year award - MRC…
https://www2.mrc-lmb.cam.ac.uk/julian-gough-wins-academic-entrepreneur-of-the-year-award/22 Sep 2020: Julian Gough has been named the Cambridge Enterprise Academic Entrepreneur of the Year for his work with Mogrify.
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Structural clues for influenza virus assembly and disassembly - MRC…
https://www2.mrc-lmb.cam.ac.uk/structural-clues-for-influenza-virus-assembly-and-disassembly/9 Sep 2020: To do this, Julia infected mammalian cells with influenza A virus, leading to production of new viruses. ... Influenza causes very large numbers of cases of severe disease and death every year and new flu strains can cause global pandemics.
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Alan Fersht and Marta Zlatic win Royal Society Medals - MRC…
https://www2.mrc-lmb.cam.ac.uk/alan-fersht-and-marta-zlatic-win-royal-society-medals/4 Aug 2020: I was thrilled to receive the news and extremely honoured that our work has been recognised in this way.”.
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Wanda Kukulski: Unlocking the secrets of membrane biology - MRC…
https://www2.mrc-lmb.cam.ac.uk/wanda-kukulski-unlocking-the-secrets-of-membrane-biology/6 Mar 2020: Correlative light and electron microscopy is a relatively new technique, and especially when combined with electron cryo-tomography, what you can see is spectacular: “It’s like watching wildlife channels”, Wanda
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SARS-CoV-2 disrupts the brain barrier in human organoids - MRC…
https://www2.mrc-lmb.cam.ac.uk/sars-cov-2-disrupts-the-brain-barrier-in-human-organoids/16 Oct 2020: They found that the virus is able to infect and produce new virus inside ChP epithelial cells, but neurons and glia were not susceptible to infection. ... With the excellent support of my supervisor, Madeline Lancaster, and the expertise of Leo James’s
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Charles Darwin’s hunch about early life was probably right - MRC…
https://www2.mrc-lmb.cam.ac.uk/charles-darwins-hunch-about-early-life-was-probably-right/12 Nov 2020: BBC FUTURE article looking back at origin of life research breakthroughs, including key research by John Sutherland that utilised UV light to form the
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Put your genes to work: contribute to medical research - MRC…
https://www2.mrc-lmb.cam.ac.uk/put-your-genes-to-work-contribute-to-medical-research/14 May 2020: Julian Gough and his group are crowdsourcing raw genomic data for a phenotype prediction study…
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RNA Society Spotlight on LMB postdoc Jailson Brito Querido - MRC…
https://www2.mrc-lmb.cam.ac.uk/rna-society-spotlight-on-lmb-postdoc-jailson-brito-querido/22 Sep 2020: This month’s RNA Society Spotlight features Jailson Brito Querido, a postdoctoral researcher in Venki Ramakrishnan’s group. Jailson describes how he
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A cellular pacemaker in the central body clock - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/a-cellular-pacemaker-in-the-central-body-clock/7 Jul 2020: Our daily cycle is controlled by a central clock known as the SCN, but it has been unclear how the network of cells that make up the SCN generate the properties that make it a strong clock. Michael Hastings’ group has identified a signalling axis
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First look at the atomic structure of thyroglobulin - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/first-look-at-the-atomic-structure-of-thyroglobulin/5 Feb 2020: Thyroglobulin, the protein precursor to the thyroid hormones T3 and T4, is the only molecule in the human body that is modified by iodine, and the modification directly leads to the formation of the thyroid hormones in the thyroid gland. But the
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Hayley Sharpe wins a 2020 Lister Institute Research Prize - MRC…
https://www2.mrc-lmb.cam.ac.uk/hayley-sharpe-wins-a-2020-lister-institute-research-prize/13 Aug 2020: Hayley Sharpe, a former PhD student with Sean Munro’s group in the Cell Biology Division, is one of four researchers to be awarded a 2020 Lister Institute
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Elyse Fischer wins the IUBMB Whelan Young Investigator Award - MRC…
https://www2.mrc-lmb.cam.ac.uk/elyse-fischer-wins-the-iubmb-whelan-young-investigator-award/16 Nov 2020: Elyse Fischer, a PhD student in David Barford’s group, receives the award for her work on the molecular mechanisms of chromosome segregation during cell division.
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The many strange long-term symptoms of Covid-19, explained - MRC…
https://www2.mrc-lmb.cam.ac.uk/the-many-strange-long-term-symptoms-of-covid-19-explained/18 Dec 2020: Article looking at the varied long-term effects of Covid-19 and the clues that latest research offers into what might be causing all the symptoms –
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First structures of α-synuclein filaments from human brain - MRC…
https://www2.mrc-lmb.cam.ac.uk/first-structures-of-%CE%B1-synuclein-filaments-from-human-brain/28 May 2020: New research from the groups of Michel Goedert and Sjors Scheres has revealed the first structures of α-synuclein filaments from human brain.
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Ankyrins: a missing molecular link in mechanical senses - MRC…
https://www2.mrc-lmb.cam.ac.uk/ankyrins-a-missing-molecular-link-in-mechanical-senses/22 Apr 2020: Hearing and touch depend on the ability of sensory neurons to be activated by a force, such as pressure or vibration from sound, and then pass information on to the brain. William Schafer’s group has identified some of the key proteins that make
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TRIM21 links antibody and T cell immunity to combat viral infection - …
https://www2.mrc-lmb.cam.ac.uk/trim21-links-antibody-and-t-cell-immunity-to-combat-viral-infection/4 Dec 2020: This reveals a new mechanism of immune synergy between antibodies and T cells, which are often thought to work quite separately. ... Therefore, this work provides multiple new concepts that could be exploited in the development of treatments for and
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Science Magazine dives into the science behind affordable cryo-EM -…
https://www2.mrc-lmb.cam.ac.uk/science-magazine-dives-into-the-science-behind-affordable-cryo-em/24 Jan 2020: In long feature format, Science Magazine profiles structural biology scientists at the LMB, including Chris Russo and Nobel Prize winner Richard
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Revolutionary microscopy technique sees individual atoms for first…
https://www2.mrc-lmb.cam.ac.uk/revolutionary-microscopy-technique-sees-individual-atoms-for-first-time/4 Jun 2020: Sjors Scheres’ and Radu Aricescu’s groups have pushed the boundaries of cryo-EM, allowing the technique to detect individual atoms in a protein for the
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Coot Cryo-EM Tutorial 2: Fitting and Mutating | Coot Development Blog
https://www2.mrc-lmb.cam.ac.uk/coot/blog/2020/10/20/Coot-Cryo-EM-main.html20 Oct 2020: Compare this maps with the original. You should find that the new (smooth) map is easier to understand. ... use the Display Manager to delete the first (mrc) map. Change the contour Step for the new Maps:. -
High-resolution structure of a GPCR-arrestin complex - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/first-high-resolution-structure-of-a-gpcr-arrestin-complex/17 Jun 2020: Understanding minute structural differences in (G protein-coupled receptor) GPCR complexes could lead to the design of more efficacious drugs that have fewer side effects
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From dawn to dusk: a day in the life of an LMB PhD student - MRC…
https://www2.mrc-lmb.cam.ac.uk/from-dawn-to-dusk-a-day-in-the-life-of-an-lmb-phd-student/28 Oct 2020: Published on. 28 October, 2020. Karen in the Lab. When the LMB Director, Jan Löwe, ran an internal video competition for staff and students to submit ideas for new films about ... I’ve always been interested in using our knowledge of biological
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A focus on how Sarah Caddy’s research has transitioned to COVID-19 -…
https://www2.mrc-lmb.cam.ac.uk/a-focus-on-how-sarah-caddys-research-has-transitioned-to-covid-19/26 Jun 2020: Sarah Caddy is interviewed about her work on COVID-19 during the pandemic and extending her work with Leo James’ group on how antibodies neutralise
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Venki Ramakrishnan is elected a Member of the American Philosophical…
https://www2.mrc-lmb.cam.ac.uk/venki-ramakrishnan-is-elected-a-member-of-the-american-philosophical-society/29 May 2020: New Members in 2020 include musicians, historians, social scientists, and researchers in the mathematical, physical, and biological sciences.
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Alexander Bates wins the 2020 British Neuroscience Association…
https://www2.mrc-lmb.cam.ac.uk/alexander-bates-wins-the-2020-british-neuroscience-association-postgraduate-award/18 Dec 2020: Alex Bates, who recently completed his PhD in Greg Jefferis’ group in the Neurobiology Division, was awarded the BNA Postgraduate prize for his work on
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A connection between stress detection and lifestyle decisions in…
https://www2.mrc-lmb.cam.ac.uk/a-connection-between-stress-detection-and-lifestyle-decisions-in-worms/24 Nov 2020: Rebecca Taylor’s group has identified a signalling molecule that connects detection of a stressful environment by the nervous system with molecular defence mechanisms in other tissues and leads to changes in feeding behaviour and reproduction.
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A map to show the way to sense smell, temperature, and humidity - MRC …
https://www2.mrc-lmb.cam.ac.uk/a-map-to-show-the-way-to-sense-smell-temperature-and-humidity/23 Jul 2020: Producing maps of how neurons connect with each other (connectomes) allows scientists to build and test theories of brain function. Greg Jefferis’ group have presented the first full map of olfactory, thermosensory, and hygrosensory projection
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Professor Kim Nasmyth awarded the 2021 Centenary Award by Biochemical …
https://www2.mrc-lmb.cam.ac.uk/professor-kim-nasmyth-awarded-the-2021-centenary-award-by-biochemical-society/25 Mar 2020: Kim, who is currently the Whitley Chair at the Department of Biochemistry, University of Oxford and a fellow of Trinity College, has made hugely valuable
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A synthetic molecule that can restore lost connections in the brain - …
https://www2.mrc-lmb.cam.ac.uk/a-synthetic-molecule-that-can-restore-lost-connections-in-the-brain/28 Aug 2020: The brain contains an enormous number of connections, known as synapses. Their loss is associated with many disorders. Radu Aricescu’s group and collaborators in Japan and Germany have designed a molecule that restores synapses in animal disease
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Opening of LMB Containment Level 3 lab fast-tracked to help fight the …
https://www2.mrc-lmb.cam.ac.uk/opening-of-lmb-containment-level-3-lab-fast-tracked-to-help-fight-the-covid-19-pandemic/23 Oct 2020: I have also started working on a new project with Radu Aricescu and Jan Löwe to test new vaccine candidates. ... chip model to understand the immune response to Mycobacterium tuberculosis and develop new drug treatments.
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Scientists create a drug that could repair damage to the brain and…
https://www2.mrc-lmb.cam.ac.uk/scientists-create-a-drug-that-could-repair-damage-to-the-brain-and-spinal-cord/1 Sep 2020: illness, offering hope of new therapies for a range of devastating conditions, from Alzheimer’s disease to epilepsy.
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Piotr Szwedziak is one of nine researchers to receive EMBO…
https://www2.mrc-lmb.cam.ac.uk/piotr-szwedziak-is-one-of-nine-researchers-to-receive-embo-installation-grants/21 Jan 2020: Piotr Szwedziak, a former PhD student and post-doctoral researcher in Jan Löwe’s group, has received an EMBO Installation Grant to establish an
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Are some people at greater genetic risk from Covid-19? MRC LMB seeks…
https://www2.mrc-lmb.cam.ac.uk/are-some-people-at-greater-genetic-risk-from-covid-19-mrc-lmb-seeks-dna-volunteers/18 May 2020: MRC LMB seeks DNA volunteers. Published on. 18 May, 2020. Cambridge Independent feature story on Julian Gough’s new phenotype prediction genome data study, which is also exploring whether DNA genotype
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A celebration of LMB women scientists at the launch of “Ahead of the…
https://www2.mrc-lmb.cam.ac.uk/a-celebration-of-lmb-women-scientists-at-the-launch-of-ahead-of-the-curve/7 Dec 2020: The LMB celebrated its latest book, Ahead of the Curve: Women Scientists at the MRC Laboratory of Molecular Biology by Kathleen Weston, with an online book launch of presentations from around the world.
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Slashing energy could make Nobel prize-winning cryo-EM microscopes…
https://www2.mrc-lmb.cam.ac.uk/slashing-energy-could-make-nobel-prize-winning-cryo-em-microscopes-more-affordable/2 Jan 2020: Proof-of-principle research led by Chris Russo showing that cryo-EM could be made 10 times cheaper is highlighted by the MRC. “Our goal is to make cryo-EM
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The origin of life on Earth explored at the LMB using a flask and a…
https://www2.mrc-lmb.cam.ac.uk/the-origin-of-life-on-earth-explored-at-the-lmb-using-a-flask-and-a-lamp/3 Jul 2020: Nicholas Green is interviewed in the Cambridge Independent about John Sutherland’s group’s recent research suggesting that DNA and RNA building blocks
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Yanlan Mao is awarded the 2021 Royal Microscopical Society Medal for…
https://www2.mrc-lmb.cam.ac.uk/yanlan-mao-is-awarded-the-2021-royal-microscopical-society-medal-for-life-sciences/6 Aug 2020: Yanlan Mao, who did her PhD with Matthew Freeman’s group in the LMB’s Cell Biology Division, has been awarded the RMS Medal for Life Sciences in
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Structures of virus-like capsids involved in learning and memory…
https://www2.mrc-lmb.cam.ac.uk/structures-of-virus-like-capsids-involved-in-learning-and-memory-formation/23 Jan 2020: The neuronal gene Arc plays important roles in neural plasticity, learning and memory-related molecular processes and has been shown to mediate intercellular RNA transfer by forming viral-like capsids. John Briggs’ group has now solved the first
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A mission to Mars and how the first life on Earth survived its…
https://www2.mrc-lmb.cam.ac.uk/a-mission-to-mars-and-how-the-first-life-on-earth-survived-its-biggest-threat-water/11 Dec 2020: Published on. 11 December, 2020. A Nature News Feature about origin of life chemistry, including key work by John Sutherland’s group, and selection of the specific destination of a NASA
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Unravelling the replisome: how a molecular machine overcomes…
https://www2.mrc-lmb.cam.ac.uk/unravelling-the-replisome-how-a-molecular-machine-overcomes-obstacles-to-dna-replication/4 May 2020: to reproduce new double-stranded DNA. ... These processes are tightly coupled by the replisome complex to avoid stretches of exposed single-stranded DNA between the point of unwinding and the point of synthesis of new DNA.
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Liz Miller: Signed, sealed, delivered - protein trafficking in the…
https://www2.mrc-lmb.cam.ac.uk/liz-miller-signed-sealed-delivered-protein-trafficking-in-the-endoplasmic-reticulum/13 Oct 2020: After hearing him talk in a new group leaders’ seminar series, Liz realised that her colleague Madan Babu, who works on intrinsically disordered proteins, could help her a lot in understanding ... The job I’ve given myself is to do preliminary
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Football is just a branch of science for Cambridge United Women…
https://www2.mrc-lmb.cam.ac.uk/football-is-just-a-branch-of-science-for-cambridge-united-women-midfielder-gisela-otten/11 Dec 2020: Gisela Otten, post-doctoral researcher in Felix Randow’s group in the LMB’s PNAC Division, talks to the Cambridge Independent about her route to joining
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Tracing a transcription initiation factor’s molecular journey across…
https://www2.mrc-lmb.cam.ac.uk/tracing-a-transcription-initiation-factors-molecular-journey-across-evolutionary-timescale/13 May 2020: M Madan Babu’s group publishes a comprehensive model for the functional innovations of TBP.
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Anthony Hyman has been elected an international member of the…
https://www2.mrc-lmb.cam.ac.uk/anthony-hyman-has-been-elected-an-international-member-of-the-national-academy-of-sciences/30 Apr 2020: The National Academy of Sciences of the USA recognises distinguished and continuing achievements in original scientific research by election to membership
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Women of the Nobel factory share their stories: Nature book review of …
https://www2.mrc-lmb.cam.ac.uk/women-of-the-nobel-factory-share-their-stories-nature-book-review-of-ahead-of-the-curve/16 Dec 2020: Georgina Ferry reviews ‘Ahead of the Curve: Women scientists at the MRC Laboratory of Molecular Biology’ by Kathleen Weston. From sequencing to stardom -
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Madeline Lancaster: The accidental organoid - mini-brains as models…
https://www2.mrc-lmb.cam.ac.uk/madeline-lancaster-the-accidental-organoid-mini-brains-as-models-for-human-brain-development/11 Feb 2020: As a very new postdoc in Jürgen Knoblich’s lab in Vienna, she was trying to get mouse neural epithelial cells to form neural rosettes, but couldn’t get the cells ... LMB trusts me to think about these questions is great.” And she’s not felt
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Cell-invading bacteria are converted into signalling platforms that…
https://www2.mrc-lmb.cam.ac.uk/cell-invading-bacteria-are-converted-into-signalling-platforms-that-may-trigger-septic-shock/15 Jun 2020: Septic shock is a common cause of death that can be triggered by LPS, a component of the outer membrane of some bacteria. Felix Randow’s group has shown how the immune response against cytosol-invading bacteria is activated by a signalling
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First complete atomic model of condensin lays foundation for…
https://www2.mrc-lmb.cam.ac.uk/first-complete-atomic-model-of-condensin-lays-foundation-for-understanding-chromosome-compaction/14 Jul 2020: Each of our cells contains about two metres of DNA. To be able to store all of this, the DNA must be very tightly compacted. Jan Löwe’s group have produced the first atomic model of condensin, a complex known to have a role in compacting DNA into
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Inspiring students to think about science in a different way through…
https://www2.mrc-lmb.cam.ac.uk/news-and-events/public-engagement/supporting-education/inspiring-students-to-think-about-science-in-a-different-way-through-dance/21 Feb 2020: the arts and sciences are a really powerful way to reach new audiences.”.
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A splice of life - Chemistry World looks at how structural biology…
https://www2.mrc-lmb.cam.ac.uk/a-splice-of-life-chemistry-world-looks-at-how-structural-biology-has-revealed-the-secrets-of-the-spliceosome/24 Mar 2020: Clare Sansom describes the history of spliceosome research and its importance, focusing on the work of Kiyoshi Nagai and his group. More...
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Emmanuel Levy has been announced as the Blavatnik Awards for Young…
https://www2.mrc-lmb.cam.ac.uk/emmanuel-levy-has-been-announced-as-the-blavatnik-awards-for-young-scientists-in-israel-2020-laureate-in-chemistry/30 Jan 2020: The Blavatnik Awards honour outstanding, innovative scientists at the early stages of their careers. Emmanuel has been recognised for his work on protein
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