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18 Sep 2019: Every year or so the LMB takes a group photo of all the current PhD students. Photos in the LMB Archive go back to at least the 1990's. Day 261 of #LMB365 shows the current cohort posing for this year’s photo – watch this space for the actual

10 Sep 2019: As the model organismC. elegansis transparent we can use it to look at subcellular organelles and use fluorescent protein tags to study different processes. This image for day 253 of #LMB365 shows two different organelles labelled with green and

14 Aug 2019: We have recently purchased a jet washer to help improve the external appearance of the site. On day 226 of #LMB365, Phil Peck from Domestic Services has started to pressure wash the paths around the LMB building. Hopefully it’s not like painting

8 Jun 2019: This image for day 160 of #LMB365 is a Drosophila melanogaster embryo showing the embryonic nervous system. Fluorescent labels correspond to microtubules (yellow) and nuclei (red). Image by Yara Sanchez-Corrales in Katja Röper’s group in the Cell

30 Dec 2019: In quieter moments between experiments, members of the LMB have had fun recreating some of our state-of-the art equipment in Lego®, as seen here on day 364 of #LMB365. This includes an NMR machine, AKTA, orbitrap mass spec and a transmission

16 Jan 2019: On day 16 of #LMB365 Laura Pellegrini @laupellegrini from Madeline Lancaster’s group @MinibrainLab in Cell Biology @CellBiol_MRCLMB has made a collage of human cerebral organoid ventricular buds. The ventricular buds are used to study the

19 Oct 2019: Day 292 of #LMB365 from Laura Pellegrini in Madeline Lancaster’s group shows a section of a cerebral organoid including a ventricular lobe, resembling the structure of the developing human cortex. It also shows an epithelial tissue named the

22 Dec 2019: As we celebrate the winter solstice, day 356 of #LMB365 shows John O’Neill’s group on an outing to visit the Corpus Clock in Cambridge. Sitting atop the clock is an extraordinary monster: the ‘Chronophage’ meaning Eater of Time. John’s

10 Dec 2019: On this day each year the Nobel Prize award ceremony and banquet is held. To celebrate this, day 344 of #LMB365 shows a very rare collection of Nobel Prize Medals awarded to members of the LMB, together with champagne bottles signed by some Nobel

24 Oct 2019: Day 297 of #LMB365 is a screenshot from our internal “Bee Cam”. It shows our resident beekeeper Geoff putting on a feeder of sugar syrup for the LMB’s bees to build up stores for the winter. The bees have also been treated for mites so

28 Aug 2019: Ketan Malhotra from Anne Bertolotti’s group and Manuel Carminati from Lori Passmore’s group recently prepped 62 litres of E.coli to harvest their protein for purification and structure determination. Day 240 of #LMB365 shows the resulting 50 ml

20 May 2019: This photo of the LMB by Ivan Rosa e Silva for day 141 of #LMB365, was taken from Hobson’s Park at Great Kneighton to the West of the Campus. Totalling around 120 acres, the park contains woodland and four ponds.

17 Jul 2019: Protein samples need to be rapidly frozen in liquid nitrogen so they can be stored without degrading. While freezing samples, Christina Heroven and Patricia Brown were surprised to see the tubes forming a perfect circle within the container as seen

8 Mar 2019: As predicted #LMBees are exploring the building and have made it as far as the LMB's Media Prep Department. As can be see on day 68 of #LMB365, they searched through pre-prepared solutions until they found something sweet. Hopefully they have left

2 Oct 2019: LMB scientists visited Ely Cathedral for LifeLab last weekend to talk to members of the public about their research on the origin of life and about how cryo-EM works. On day 275 of #LMB365, we see some LMB volunteers carrying the backdrop of the

20 Sep 2019: Much of the research at the LMB must be conducted in carefully controlled conditions of temperature, vibration and magnetic fields. The Electronics Workshop works with Group Leaders to detect and analyse extremely small sources of potential

8 Aug 2019: This image for day 220 of #LMB365 shows a digitalized patch of cells within the Drosophila melanogaster embryo. Cell-to-cell interfaces are randomly coloured and cell centroids are depicted with a square. Image by Yara Sanchez-Corrales in Katja

23 Apr 2019: Day 114 of #LMB365. Ferris Beuller would never go to the lab on such a spectacular spring day! But if you don’t have access to a 1961 Ferrari GT, you might as well be in the LMB doing experiments.

7 Aug 2019: Stands the church clock at ten to three. And is there honey still for tea? On Day 219 of #LMB365 are some of the first jars of honey produced this year from the #LMBee. 60 jars went on sale to staff and sold out within a couple of hours

5 Jul 2019: Day 186 of #LMB365 shows a common occurrence at the LMB. Our Nobel laureates, on this occasion Venki Ramakrishnan, and others are frequently called upon to be interviewed about their science. More can be found on our YouTube channel at

13 Mar 2019: Day 73 of #LMB365 brings you a group photograph of the MRC Council who held their recent meeting here at the LMB. The MRC Council is responsible for advising the MRC Executive Chair and making decisions, as delegated to it by the UKRI Board, on

26 Aug 2019: Day 238 of #LMB365 shows a cerebral organoid ventricle labelled with markers of neuroepithelial cells, neuronal progenitors and neurons from Laura Pellegrini in Madeline Lancaster’s group in Cell Biology. The complex structural organisation of

25 Jan 2019: Day 25 of #LMB365 is a close up of the fruit fly Drosophila Melanogaster. These are used to study development in the group of @katjaroeper in Cell Biology @CellBiol_MRCLMB. These fluorescent flies in their cage lay GFP-expressing embryos which are

14 Oct 2019: On day 287 of #LMB365 we see an image of a bee’s leg taken by a pupil at Stapleford Primary School and submitted for the LMB’s 2019 Science Image Award. We’re now starting to recruit nearby primary schools for next year’s competition

19 Mar 2019: This drawing for day 79 of #LMB365 is by Paul Margiotta #piljammin in the LMB’s Visual Aids team. It is an abstract interpretation of the LMB's use of X-rays to reveal hitherto undefined protein structures overlaid with the period feel of the film

13 Aug 2019: On day 225 of #LMB365 is Fred Sanger who was born #OTD in 1918. He is the only Briton to have been awarded two @Nobel prizes and the only scientist to

6 Jan 2019: Day 6 of #LMB365 is provided by @as_bates and @gsxej who are working on circuits in the brain of the fruit fly D. Melanogaster. The image shows over a thousand neurons from the fly's ‘instinct centre’, which is similar to the human amygdala, and

17 Sep 2019: Day 260 of #LMB365 shows Michael Fuller, who was born on this day in 1936. He served the LMB for over 44 years, as apprentice technician, Steward, Laboratory Services Manager and Special Projects Co-ordinator. This photo, taken at Venki

22 May 2019: On day 143 of #LMB365, we celebrate the 6th anniversary of the official opening of the current LMB building. HM The Queen, accompanied by HRH The Duke of Edinburgh, is seen walking through the LMB Atrium, escorted by the then LMB Director Hugh Pelham

5 Jun 2019: Day 157 of #LMB365 shows an artistic view of a ribosome engineering process created by Zakir Tnimov and Wolfgang Schmied in Jason Chin’s group. This ‘stapled’ ribosome has subunits linked by an RNA hinge and can be evolved for synthetic

9 Jul 2019: Day 190 of #LMB365 shows some plastic measuring cylinders. There are over 1200 cylinders in cupboards across the LMB ranging from 10ml to 2litres. These are washed and replaced by the Glasswash Team on a daily basis & without their dedication LMB

31 Dec 2019: As 2019 draws to a close and we get to day 365 of #LMB365 the whole LMB wants to say thank you for following this project. We hope you’ve enjoyed seeing the images as much as we’ve enjoyed pulling them together and that you’ve discovered

2 Nov 2019: Ice contamination is the last thing you want to see on your cryo-EM grid, as charging of the ice under the electron beam is a common source of image drift at high magnification. However, sometimes while screening your sample it is nice to come

26 Jul 2019: On day 207 of #LMB365, the LMBee has been exploring the wonderful LMB Archive. The Archive has a diverse collection of resources and information about the LMB, its science and people. Here, the LMBee sits in one of the display cabinets, amongst a

19 Dec 2019: Day 353 of #LMB365 shows the LMB Library sprouts in quiet discussion about their Christmas preparations and wish lists. Sprout one is hoping Santa is going to bring them a copy of the Nordic Baking Book. Sprout two would really like some fancy

25 Sep 2019: This image for day 268 of #LMB365 shows the brain and some imaginal discs isolated from a Drosophila larva. Imaginal discs are sacks of cells that will develop into adult structures such as wings, legs and eyes during metamorphosis. The tissue was

19 Sep 2019: Day 262 of #LMB365 shows a confocal image of a gravid Caenorhabditis elegansworm from Ranya Behbehani in Rebecca Taylor’s lab in the Neurobiology Division. This model organism has been used at the LMB for many years since the initial studies on

9 May 2019: This picture for day 130 of #LMB365 by Thomas Mund shows a confocal image of the GFP-stained cytoskeletal remnants of a HeLa cell, an immortal cell line used in scientific research at the LMB. Sometimes beauty lies beyond what you are originally

13 Jan 2019: Day 13 of #LMB365 celebrates LMB Nobel Laureate @NobelPrize Sydney Brenner. Born on this day in 1927 in South Africa, he was jointly awarded the Nobel Prize for Physiology or Medicine in 2002 for discoveries concerning the genetic regulation of

29 Mar 2019: The image for day 89 of #LMB365 is provided by Oleksiy Kovtun. This EM image shows phage particles tangled in bacterial flagella. Bacteria are used as a protein expression host to allow the purification of large amounts of the protein of interest,

6 Dec 2019: Simon Bullock’s lab uses a combination of in vitro and in vivo methods to investigate how microtubule-based cargo transport is orchestrated in cells. On day 340 of #LMB365 Simon illustrates this approach by overlaying a crystal structure from a

9 Nov 2019: The image for day 313 of #LMB365 shows apical localisation of thehmRNA (magenta) in the fruit fly embryo. This mRNA is trafficked by the microtubule motor dynein and Simon Bullock’s group in Cell Biology has used this system to shed light on how

13 Feb 2019: Day 45 of #LMB365 is a ventricular zone of a cerebral organoid labelled for neuronal progenitors and cells in division. This was taken by Laura Pellegrini from Madeline Lancaster’s group in the Cell Biology Division. The cerebral organoids

27 Feb 2019: On day 59 of #LMB365 we have a close-up of a large scale oligonucleotide synthesiser used by John Sutherland’s group in the LMB’s PNAC Division to make sufficient amounts of RNA oligonucleotides for NMR experiments to investigate the sort of

24 Sep 2019: LMB scientists will be taking C. elegans worms to Queensgate shopping centre in Peterborough on Saturday 28th September to tell members of the public about how we use worms to study how neurons work and improve our understanding of ageing and disease

23 Aug 2019: On day 235 of #LMB365 PhD student Ross Hill celebrates with fellow students and postdocs the publication of his first paper from his PhD. The culmination of 3½ years of work and the ultimate accolade: to see your work reaching the scientific

29 Apr 2019: On day 120 of #LMB365 we find some LMB PhD students “relaxing” by bouldering at a local climbing centre after a long day in the lab. Abilities varied, but they all enjoyed themselves and ended up with a well-deserved pint in a local pub.

30 Jul 2019: Day 211 of #LMB365 shows a cerebral organoid section with large ventricles from Laura Pellegrini in Madeline Lancaster’s group in Cell Biology. Cell nuclei are labelled in blue and the apical marker ZO1 in white highlights the perimeter of the

14 Oct 2019: 2019/Jan Lab homepage's updated! (Check out our new publications & members etc). ... 2017/Sep A new PhD student's just joined our lab! Welcome, Eva!

14 Oct 2019: Rabinowitch I, Schafer WR (2015), "Engineering new synaptic connections in C. ... Engineering new synaptic connections in C. elegans" Worm Epub 28 Jan 2015.