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5 Jun 2015: Miscarriages and genetic disorders, such as Down's syndrome, are often caused by errors when an egg develops from its progenitor cell, the oocyte. Most

20 Jul 2015: Madan Babu Mohan, group leader in the LMB’s Structural Studies Division, has been awarded the Royal Society Francis Crick Medal and Lecture 2016. The

27 Mar 2015: Children queued up excitedly during the Saturday and Sunday daytime sessions to use the microscopes, and the exhibit was also very popular in the new adults-only session on the Saturday

25 Jun 2015: Genes in eukaryotic organisms are frequently interrupted by non-coding segments called introns. Before the protein can be produced, the entire length of each gene including the introns, is transcribed to produce precursor messenger RNA (pre-mRNA).

21 Sep 2015: She then continued her work in the United States where she held Research Associate positions at the Rockefeller University, New York University Langone Medical Center and the Skirball Institute of Biomolecular

19 Oct 2015: Ribosomes, the molecular machines in cells that make proteins, are constructed in a series of discrete steps to create both a large and a small subunit.

1 Jul 2015: Brain Chat - a podcast answering key questions about brain and behaviour, with Hannah Critchlow reporting on exciting brain research revolutions presented

15 Jul 2015: The annual Eastern Region Crystal Growing Competition for Schools has been hosted at the LMB since 1998. The competition, designed to inspire children

18 Aug 2015: Abstract: They started out as a useful tool for studying the immune system in the lab and now they're a family of drugs treating millions of patients,

3 Jun 2015: The pioneering career of LMB Alumnus Joan Steitz, currently Sterling Professor of Molecular Biophysics and Biochemistry at Yale University is featured by

5 May 2015: There is compelling evidence that in the distant past, our single-celled ancestors used RNA, a chemical cousin of DNA, for both genetic information

13 Nov 2015: 26 AS-level students on an intensive week of “Biology and Genetics for Gifted and Talented students” recently visited the LMB for a day of practical work.

25 Sep 2015: This new knowledge has implications for human health: children effected by the cancer and bone marrow failure syndrome Fanconi anaemia are unable to repair the DNA damage caused by formaldehyde.

27 Apr 2015: The structure of the actin-like protein ParM in different states has been revealed by Tanmay Bharat and Jan Löwe in collaboration with Garib Murshudov

18 Mar 2015: Bacterial ribosomes are different from those in higher organisms, making them good targets for drugs, so this information is critical in developing new antibiotics to combat infection and disease.

19 May 2015: Jason Chin’s group from the LMB’s PNAC Division have created a new technique called BOLT that can selectively regulate specific proteins inside cells that could not previously be targeted. ... affected. Genetically engineering an entirely new site

16 Sep 2015: During mid-September the Black Dog statue, 'Horace', will sit outside the main entrance of the LMB. Horace is the symbol of the charity SANE’s campaign to

12 Oct 2015: The LMB's Alexey Amunts has been awarded the 2015 George Palade Award by the Microscopy Society of America for distinguished contributions to the field of

3 Jul 2015: This pioneering study shows that cryo-EM can be used for rational drug design, and could help the development of new therapeutic drugs for the treatment of conditions such as cancer,

13 Feb 2015: Emeritus group leader Cyrus Chothia, from the LMB’s Structural Studies Division, has been honoured with two awards for his ground-breaking work in the use

9 Oct 2015: The structure of the Vps34 complex may facilitate new approaches to developing both inhibitors and activators of autophagy.

24 Sep 2015: Sjors Scheres, LMB group leader, awarded the Royal Netherlands Chemical Society Gold Medal. The KNCV Gold Medal is the highest Dutch award for Chemistry.

11 Aug 2015: They are tiny magic bullets that are quietly shaping the lives of millions of patients around the world. Monoclonal antibodies are contained in six out of

11 Dec 2015: Representatives from across the UK life science community joined Understanding Animal Research at the Wellcome Collection in London recently to celebrate

10 Nov 2015: During the summer of 2015 Cancer Research UK launched a DNA inspired art trail across London with a series of 21 DNA double helix sculptures. They invited

26 Mar 2015: Published on. 26 March, 2015. FORMA Therapeutics and Cancer Research Technology, Ltd (CRT) have announced the formation of two new virtual Asset Discovery and Development Companies (ADDCos) to represent the collective

17 Aug 2015: The atomic structure of the 170 kDa membrane protein gamma-secretase, a membrane protein complex that has an important role in Alzheimer’s disease, has

26 Nov 2015: DNA damage represents a constant threat to the integrity of genomic information in cells and is closely linked to the origins of cancer. 

8 Sep 2015: Coot displays a Map Colour Selection window]. • Choose a new colour by clicking on the colour widgets. ... Coot adds intermediate white atoms and pops up a dialog]. • Accept the new atoms.

26 Jun 2015: Discard the pipet tip, add a new pipet tip and pipet 1 ml of Crystal Screen Lite reagent 2 into reservoir A2.

15 Apr 2015: MRC science needs to be effectively translated into powerful new therapies, diagnostics, devices, and research tools. ... then for investigating other potential protein modifications. The technology will help produce new protein reagents that.

11 Jul 2015: The body breaks proteins down into their individual building blocks, called "amino acids" and then uses the amino acids to build new proteins like dynein.

8 Sep 2015: Each new top score is highlighted () and the coordinates are updated to the final highest score.

20 Oct 2015: Engineering new synaptic connections in the C.elegans connectome. Ithai Rabinowitch & William R Schafer. ... 3B, right), presumablydue to negative charge flowing fromAWC into AIY through the new electricalsynapse (Fig.

27 Aug 2015: Coot displays a Map Colour Selection window]. • Choose a new colour by clicking on the colour widgets. ... We want a CYS:. • Mutate & Auto Fit. • Click on an atom in the new ALA.

16 Jul 2015: wwPDB Ligands. Year on year increase in the number of new entities. ... 6943 new ligand types (88%) are non-polymers. – LINKed ligands excluded.

14 Aug 2015: New imaging technology has made it possible to record neural activity from the majority ofC. ... 2. Lehner PN. Handbook of ethological methods. 2nd ed. Cambridge ; New York: Cambridge UniversityPress; 1996.

4 Feb 2015: New York, NY 10032, USA.}Present address: Department of Biochemistry. and Biophysics, University of California,. ... New York, NY 10010, USA. Electronic supplementary material is available. at http://dx.doi.org/10.1098/rsif.2014.0963 or.

30 Jun 2015: RESEARCH ARTICLE. Sensory Neurons Arouse C. elegansLocomotion via Both Glutamate andNeuropeptide ReleaseSeungwon Choi1,2,3, Kelsey P. Taylor1,2,3, Marios Chatzigeorgiou4, Zhitao Hu1,2,William R. Schafer4, Joshua M. Kaplan1,2,3. 1 Department of

27 Apr 2015: Clearly, new TubZ monomers incorporated only at thefilament ends that were free of TubRC (Fig. ... pH 7.5), 500 mM KCl, 10 mM EDTA, 0.5 mM TCEP] by chitin-affinity chromatography (New England Biolabs).

24 Sep 2015: treatment leads to improvement of ABCG2 mutant trafficking.We first determined whether the increased ABCG2 expressionon the cell surface required new protein synthesis. ... Here, we highlighted a new molecularmechanism, HDIs acting as modulators of

19 Aug 2015: The eRF1(AAQ) mutant was generated via Phusion mutagenesis.Antibodies against Hbs1 and ABCE1 have been described32; the eRF1 antibodywas from New England Biolabs.Release factor purification.

9 Sep 2015: Cotransin appears to trap the new protein chain within the Sec61 channel by essentially ‘locking’ the side-gate. ... By preventing the plug from moving out of the way, cotransin can somehow stop the new protein from passing through the side-gate.

24 Sep 2015: An ER Complex of ODR-4 and ODR-8/Ufm1 SpecificProtease 2 Promotes GPCR Maturation by a Ufm1-Independent MechanismChangchun Chen, Eisuke Itakura, Katherine P. Weber, Ramanujan S. Hegde, Mario de Bono. MRC Laboratory of Molecular Biology, Cambridge,

11 Aug 2015: PNGase F was from New England Biolabs (Ipswich, MA). Crude reticulocyte lysate was obtained from Green Hectares (Madison, WI).

11 Aug 2015: The new structuresshow how SRP cradles the targeting signal inside a binding groove and covers it with a protective lidto minimize its risk of aggregation.