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Harnessing computer power to understand biology - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/harnessing-computer-power-to-understand-biology/9 Jul 2015: In an interview for Science Careers, former LMB Group Leader Sarah Teichmann talks about how she was inspired by computational biology by Cyrus Chothia,
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Molecular clocks control mutation rate in human cells - MRC…
https://www2.mrc-lmb.cam.ac.uk/molecular-clocks-control-mutation-rate-in-human-cells/12 Nov 2015: New research suggests that cancer and ageing could be predetermined by the speed of molecular clocks.
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Biologist Venki Ramakrishnan to lead Royal Society - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/biologist-venki-ramakrishnan-to-lead-royal-society/19 Mar 2015: He will succeed Paul Nurse in December 2015. After hearing of the confirmation, Venki told the BBC News that he was “very honoured” to be the society’s president elect.
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ISCB Senior Scientist Award for Cyrus Chothia - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/iscb-senior-scientist-award-for-cyrus-chothia/28 May 2015: A look at the career of LMB's Cyrus Chothia and his work on the structures and functions of proteins, following announcement of his ISCB Senior scientist
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Venki Ramakrishnan at World Economic Forum in Davos - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/venki-ramakrishnan-world-economic-forum-davos/23 Jan 2015: The end of the antibiotic age? The LMB's Venki Ramakrishnan took part in a panel discussion on the problem of antibiotic resistance at the World Economic
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LMB HR raise £194 at Macmillan Coffee Morning - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/lmb-hr-raise-194-at-macmillan-coffee-morning/1 Oct 2015: The HR team at the LMB had to hone their baking skills in preparation for the Macmillan Cancer Support World’s Biggest Coffee Morning, on Friday 25th
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Two LMB papers chosen as major historical landmarks in research - MRC …
https://www2.mrc-lmb.cam.ac.uk/two-lmb-papers-chosen-as-major-historical-landmarks-in-research/17 Mar 2015: The Royal Society Philosophical Transactions is celebrating 350 years of publishing scientific research with a special issue of commentary articles. These
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LMB supports county-wide STOP Suicide campaign - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/lmb-supports-county-wide-stop-suicide-campaign/9 Oct 2015: The LMB has strengthened its commitment to supporting the mental wellbeing of its staff and students by signing the STOP Suicide Organisational Pledge.
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LMB spin-out, Heptares Therapeutics, acquired by Sosei Group - MRC…
https://www2.mrc-lmb.cam.ac.uk/lmb-spin-heptares-therapeutics-acquired-sosei-group/23 Feb 2015: Understanding their structure at a molecular level helps us to design new and more effective drugs to combat many human illnesses. ... The acquisition secures significant investment into the technology platform and clinical pipeline, and will advance
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Megan Davies awarded MBE in Queen’s Birthday Honours - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/megan-davies-awarded-mbe-in-queens-birthday-honours/15 Jun 2015: In this role, she oversaw a significant increase in research activity, being actively involved in the creation of four new units, and helping the new Directors get started. ... Megan obtained a PhD in Biochemistry at the University of Cambridge before
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Dynactin complex structure revealed by electron cryo-microscopy - MRC …
https://www2.mrc-lmb.cam.ac.uk/dynactin-complex-structure-revealed-electron-cryo-microscopy/18 Feb 2015: Dynactin is a protein complex that activates the dynein motor protein, enabling intracellular transport. It is extremely flexible and has proved very
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Golden grids for electron microscopy licensed by Quantifoil - MRC…
https://www2.mrc-lmb.cam.ac.uk/golden-grids-for-electron-microscopy-licensed-by-quantifoil/30 Mar 2015: New specimen support grids for electron microscopy, made of pure gold and designed by Lori Passmore and Chris Russo from the LMB’s Structural Studies Division, have been licensed for production ... The traditional carbon grids that are used to support
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2015 César Milstein Lecture to be given by Lewis Cantley - MRC…
https://www2.mrc-lmb.cam.ac.uk/2015-milstein-lecture-to-be-given-by-lewis-cantley/8 Dec 2015: Lewis is currently Director at the Meyer Cancer Center, Weill Cornell Medicine and New York Presbyterian Hospital, New York. ... He then went on to join the faculty of Weill Cornell Medical College and New York-Presbyterian Hospital in 2012.
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LMB science portrayed in art: ‘Lens on Life’ exhibition in London -…
https://www2.mrc-lmb.cam.ac.uk/lmb-science-portrayed-art-lens-life-exhibition-london/20 Jan 2015: This high profile exhibition explores cell division through works of art, with the aim of providing a new perspective on the processes of mitosis and meiosis.
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Greg Winter receives Scrip's Lifetime Achievement Award - MRC…
https://www2.mrc-lmb.cam.ac.uk/greg-winter-receives-scrips-lifetime-achievement-award/4 Dec 2015: The Scrip Awards provides the industry with an opportunity to acknowledge and applaud its highest achievers across all parts of the value chain, and to
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Effects of caffeine on the human circadian clock - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/effects-of-caffeine-on-the-human-circadian-clock/17 Sep 2015: New research by John O’Neill, in the LMB’s Cell Biology Division, and Kenneth Wright, at the University of Colorado, has revealed the mechanism by which caffeine affects the human ... westward, as well as sustaining wakefulness until bedtime in the
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2015 Max Perutz Science Writing Award shortlist announced - MRC…
https://www2.mrc-lmb.cam.ac.uk/2015-max-perutz-science-writing-award-shortlist-announced/29 Sep 2015: Barry Bentley, a PhD student in the LMB's Neurobiology Division, is one of 14 exceptional writers to be shortlisted for the Max Perutz Science Writing
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Cambridge scientists unlock cause of some types of infertility - MRC…
https://www2.mrc-lmb.cam.ac.uk/cambridge-scientists-unlock-cause-of-some-types-of-infertility/22 Jun 2015: 22 June, 2015. LMB’s Melina Schuh, in collaboration with Bourn Hall Clinic, may have found the cause of some types of infertility, including recurrent miscarriage, after new research found some ... This article is no longer available from the source
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Researchers grow brain parts to study development, disease - MRC…
https://www2.mrc-lmb.cam.ac.uk/researchers-grow-brain-parts-to-study-development-disease/9 Nov 2015: Dozens of labs are growing lumps of human brain tissue - brain organoids - for study, including LMB's Madeline Lancaster. Scientists say the technology
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Reaction map suggests meteorite chemistry route to life - MRC…
https://www2.mrc-lmb.cam.ac.uk/reaction-map-suggests-meteorite-chemistry-route-to-life/18 Mar 2015: LMB scientists have found a reaction network that they believe shows that 'pretty much everyone' working on life's molecular origins is wrong - but also
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LMB CamAWiSE annual ‘What next in your career’ event - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/lmb-camawise-annual-what-next-in-your-career-event/24 Jun 2015: After various postdoc positions she joined Greg Winter’s lab at the LMB where she worked developing new bicyclic peptides.
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LMB contribution towards UK bioscience success illuminated - MRC…
https://www2.mrc-lmb.cam.ac.uk/lmb-contribution-towards-uk-bioscience-success-illuminated/25 Jun 2015: The stories behind three great LMB successes are highlighted in a report by the UK BioIndustry Association (BIA). Humira, the first fully humanised
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Making Sense of the Chemistry That Led to Life on Earth - MRC…
https://www2.mrc-lmb.cam.ac.uk/making-sense-of-the-chemistry-that-led-to-life-on-earth/7 May 2015: Published on. 7 May, 2015. An article in the New York Times highlights the work of John Sutherland, a group leader at the LMB, who has determined a possible chemical pathway
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Image of the Week: Structure of the dynactin complex - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/image-of-the-week-structure-of-the-dynactin-complex/27 Mar 2015: The structure of the dynactin complex, solved by Andrew Carter's group at the LMB, is the cover story on this week's Science and is the Wellcome Trust's
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Basic research could lead to fertility improvements, says LMB's…
https://www2.mrc-lmb.cam.ac.uk/basic-research-lead-fertility-improvements-says-lmbs-melina-schuh/18 Feb 2015: Published on. 18 February, 2015. The Cambridge News highlights Melina Schuh’s work on the development of mammalian oocytes into fertilisable eggs. ... This article is no longer available from the source website: Cambridge News 17 February 2015.
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LMB 'Virus Wars' stand at Big Biology Day, 17th October - MRC …
https://www2.mrc-lmb.cam.ac.uk/lmb-virus-wars-stand-at-big-biology-day-17th-october/16 Oct 2015: LMB will be showing their 'Virus Wars: Antibodies Strike Back' stand at the 2015 Big Biology Day, Saturday 17th October, Hills Road 6th Form College. Come
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British biotech Heptares snapped up by Japan's Sosei in $400m…
https://www2.mrc-lmb.cam.ac.uk/british-biotech-heptares-snapped-japans-sosei-400m-deal/25 Feb 2015: The Telegraph reports that the LMB spin-out company Heptares has been acquired by Japanese pharmaceutical company Soseito. The group's research and
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First RNAi meiosis screen in mammals reveals genes essential to…
https://www2.mrc-lmb.cam.ac.uk/first-rnai-meiosis-screen-in-mammals-reveals-genes-essential-to-generate-eggs/7 Jul 2015: Published on. 7 July, 2015. During fertilisation, an egg and a sperm fuse to form a new embryo. ... This is the first RNAi screen for meiotic genes in mammals and its development has allowed Melina’s group to analyse the function of nearly 800 genes,
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Simon Bullock and Philipp Holliger elected to EMBO membership - MRC…
https://www2.mrc-lmb.cam.ac.uk/simon-bullock-and-philipp-holliger-elected-to-embo-membership/20 May 2015: list of new members announced on the 20th of May. ... EMBO elects new members annually on the basis of scientific excellence and outstanding research contributions.
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Science Minister tours "extraordinary" MRC Molecular…
https://www2.mrc-lmb.cam.ac.uk/science-minister-tours-extraordinary-mrc-molecular-biology-lab/22 Oct 2015: Universities and Science Minister Jo Johnson visited the MRC Laboratory of Molecular Biology (LMB) in Cambridge last week to see first-hand some of the
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Discovering the origins of biological timekeeping - MRC Laboratory of …
https://www2.mrc-lmb.cam.ac.uk/discovering-the-origins-of-biological-timekeeping/20 Apr 2015: The existence of an endogenous daily clock in humans is well known: it is what drives the 24-hour sleep/wake rhythm to match the daily cycle of night and
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Staff show their creative side at the LMB Art Exhibition - MRC…
https://www2.mrc-lmb.cam.ac.uk/staff-show-their-creative-side-at-the-lmb-art-exhibition/3 Aug 2015: Nearly 30 LMB staff have shown off their creativity at the annual LMB Art Exhibition, an opportunity for staff to showcase their varied artistic talents.
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In the beginning was the U1A protein: a personal reflection - MRC…
https://www2.mrc-lmb.cam.ac.uk/in-the-beginning-was-the-u1a-protein-a-personal-reflection/17 Mar 2015: LMB’s Kiyoshi Nagai looks back on his research on the spliceosome, RNA-protein interactions and the RNA recognition motif, U1A protein, for RNA
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Atomic structure of the anaphase-promoting complex (APC/C) - MRC…
https://www2.mrc-lmb.cam.ac.uk/atomic-structure-of-the-anaphase-promoting-complex-apcc/15 Jun 2015: The atomic structure could help lead to new cancer treatments by providing a framework for the rational development of anti-cancer drugs.
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Common origins of RNA, proteins and lipids on earth - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/common-origins-of-rna-proteins-and-lipids-on-earth/17 Mar 2015: How did life first originate on this planet? Even the most minimal cell needs three subsystems: to convey information, to create compartments, and to
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Mechanism-based therapeutics of common human neurodegenerative…
https://www2.mrc-lmb.cam.ac.uk/mechanism-based-therapeutics-of-common-human-neurodegenerative-diseases/6 May 2015: This initiative, developed by Michel Goedert and Alastair Compston, aims to identify core mechanisms of protein aggregation and spreading in neurodegeneration, and to apply that knowledge to study putative new therapies.
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Encoding phosphoserine allows production of phosphorylated proteins - …
https://www2.mrc-lmb.cam.ac.uk/encoding-phosphoserine-allows-production-of-phosphorylated-proteins/2 Jun 2015: However, a new method developed by Jason Chin’s group in the LMB’s PNAC Division could revolutionise this research. ... Daniel also rewired the cell’s serine metabolism to incorporate a new version of phosphoserine that could not be hydrolysed
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Zooming in on molecular motors
https://www2.mrc-lmb.cam.ac.uk/groups/cartera-jmol/jmol/ZoomOnDynein.html11 Jul 2015: The body breaks proteins down into their individual building blocks, called "amino acids" and then uses the amino acids to build new proteins like dynein. -
Cambridge Neuroscience 2015 Seminar at the LMB: Brain Chat podcast -…
https://www2.mrc-lmb.cam.ac.uk/cambridge-neuroscience-2015-seminar-at-the-lmb-brain-chat-podcast/1 Jul 2015: Brain Chat - a podcast answering key questions about brain and behaviour, with Hannah Critchlow reporting on exciting brain research revolutions presented
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Madan Babu Mohan awarded the Royal Society Francis Crick Medal and…
https://www2.mrc-lmb.cam.ac.uk/madan-babu-mohan-awarded-the-royal-society-francis-crick-medal-and-lecture-2016/20 Jul 2015: Madan Babu Mohan, group leader in the LMB’s Structural Studies Division, has been awarded the Royal Society Francis Crick Medal and Lecture 2016. The
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Hands-on activities by LMB scientists at the Cambridge Science…
https://www2.mrc-lmb.cam.ac.uk/hands-on-activities-by-lmb-scientists-at-the-cambridge-science-festival/27 Mar 2015: Children queued up excitedly during the Saturday and Sunday daytime sessions to use the microscopes, and the exhibit was also very popular in the new adults-only session on the Saturday
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Joan A. Steitz: A place in the lab, and in biochemistry history - MRC …
https://www2.mrc-lmb.cam.ac.uk/joan-a-steitz-a-place-in-the-lab-and-in-biochemistry-history/3 Jun 2015: The pioneering career of LMB Alumnus Joan Steitz, currently Sterling Professor of Molecular Biophysics and Biochemistry at Yale University is featured by
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From tool to therapy: a timeline of monoclonal antibody technology -…
https://www2.mrc-lmb.cam.ac.uk/from-tool-to-therapy-a-timeline-of-monoclonal-antibody-technology/18 Aug 2015: Abstract: They started out as a useful tool for studying the immune system in the lab and now they're a family of drugs treating millions of patients,
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The Worm Wide Web – Max Perutz Science Writing Award - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/the-worm-wide-web-max-perutz-science-writing-award/4 Nov 2015: To understand the role of these new connections, I am looking at their placement in the wider network of physical wiring. ... Using these new techniques, we are making exciting discoveries about the monoamines.
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Understanding the maternal age effect in human oocytes - MRC…
https://www2.mrc-lmb.cam.ac.uk/understanding-the-maternal-age-effect-in-human-oocytes/15 Dec 2015: Human eggs are frequently aneuploid, meaning they have the wrong number of chromosomes, and this is a major cause of pregnancy loss and Down syndrome.
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Human egg defects caused by error-prone spindle assembly - MRC…
https://www2.mrc-lmb.cam.ac.uk/human-egg-defects-caused-by-error-prone-spindle-assembly/5 Jun 2015: Miscarriages and genetic disorders, such as Down's syndrome, are often caused by errors when an egg develops from its progenitor cell, the oocyte. Most
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Spliceosome U4/U6.U5 tri-snRNP structure revealed by cryo-EM - MRC…
https://www2.mrc-lmb.cam.ac.uk/spliceosome-u4u6-u5-tri-snrnp-structure-revealed-by-cryo-em/25 Jun 2015: Genes in eukaryotic organisms are frequently interrupted by non-coding segments called introns. Before the protein can be produced, the entire length of each gene including the introns, is transcribed to produce precursor messenger RNA (pre-mRNA).
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Crystal Growing Competition for schools: winning pupils visit the LMB …
https://www2.mrc-lmb.cam.ac.uk/crystal-growing-competition-for-schools-winning-pupils-visit-the-lmb/15 Jul 2015: The annual Eastern Region Crystal Growing Competition for Schools has been hosted at the LMB since 1998. The competition, designed to inspire children
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Cryo-EM imaging of ribosomes shows the origin of leukaemia - MRC…
https://www2.mrc-lmb.cam.ac.uk/cryo-em-imaging-of-ribosomes-shows-the-origin-of-leukaemia/19 Oct 2015: Ribosomes, the molecular machines in cells that make proteins, are constructed in a series of discrete steps to create both a large and a small subunit.
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Freeze-thaw cycles turn life’s simple building blocks into functional …
https://www2.mrc-lmb.cam.ac.uk/freeze-thaw-cycles-turn-lifes-simple-building-blocks-into-functional-macromolecules/5 May 2015: There is compelling evidence that in the distant past, our single-celled ancestors used RNA, a chemical cousin of DNA, for both genetic information
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