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Heptares and the MRC extend GPCR collaboration - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/heptares-and-the-mrc-extend-gpcr-collaboration/25 Jun 2012: “Heptares Therapeutics, the leading GPCR drug discovery company, has extended its collaboration with the MRC, in particular the research group led by -
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/latest_…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/latest_news_fs/lat_layout.html9 Feb 2012: -
Greg Winter awarded Prince of Asturias Science Award - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/greg-winter-awarded-prince-of-asturias-science-award/1 Jun 2012: Greg Winter, former Deputy Director of the LMB, has been jointly awarded the Spanish "Prince of Asturias Award for Technical and Scientific Research -
Bicycle Therapeutics secures £3.75 million investment - MRC…
https://www2.mrc-lmb.cam.ac.uk/bicycle-therapeutics-secures-3-75-million-investment/18 Dec 2012: Bicycle Therapeutics, an LMB spin out company, is to start work on its first drug candidates after it raised £3.75 million in VC investment, its first -
2012 Max Perutz lecture to be given by Steve West - MRC Laboratory of …
https://www2.mrc-lmb.cam.ac.uk/2012-max-perutz-lecture-to-be-given-by-steve-west/6 Sep 2012: On completing his PhD, Steve moved to Yale University in New Haven in 1978. ... This move would lead to him becoming a pioneer in the new field of molecular biology, co-founding a world-class research laboratory and developing a technique to unlock the -
Short evolutionary path from DNA to RNA polymerases revealed - MRC…
https://www2.mrc-lmb.cam.ac.uk/short-evolutionary-path-from-dna-to-rna-polymerases-revealed/11 Jun 2012: 11 June, 2012. New research, led by Philipp Holliger’s group in the LMB’s PNAC Division, has shed new light on the mechanism by which DNA polymerases – the enzymes responsible -
BBC2 programme on the cell features TRIM21 research - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/bbc2-programme-on-the-cell-features-trim21-research/20 Oct 2012: There is an battle playing out inside your body right now. It started billions of years ago and it is still being fought in every one of us every minute -
Addenbrooke's celebrates opening by the Queen 50 years ago - MRC…
https://www2.mrc-lmb.cam.ac.uk/addenbrookes-celebrates-opening-by-the-queen-50-years-ago/28 May 2012: 28 May, 2012. “The “new” Addenbrooke’s opened on 28 May 1962. -
LMB has been awarded £49m to study the human brain - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/lmb-has-been-awarded-49m-to-study-the-human-brain/27 Mar 2012: The award will also fund an increased focus on the processes affecting cellular damage and ageing, and a new Centre for Chemical and Synthetic Biology.”Primary Sidebar. -
LMB Congratulates John Gurdon on Nobel Prize Announcement - MRC…
https://www2.mrc-lmb.cam.ac.uk/lmb-congratulates-john-gurdon-on-nobel-prize-announcement/8 Oct 2012: The LMB is delighted to congratulate alumnus John Gurdon on the award of the 2012 Nobel Prize for Physiology or Medicine. John shares the award with -
2012 César Milstein Lecture to be given by Bruce Beutler - MRC…
https://www2.mrc-lmb.cam.ac.uk/2012-milstein-lecture-to-be-given-by-bruce-beutler/9 May 2012: Professor Bruce Beutler will give the 2012 Milstein Lecture on Thursday 17 May 2012 at 4.15pm in the LMB's Max Perutz Lecture Theatre. The lecture, -
John Sutherland co-wins the Origin of Life Challenge - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/john-sutherland-co-wins-the-origin-of-life-challenge/8 Jun 2012: John Sutherland, from the LMB's Protein & Nucleic Acid Chemistry Division, has won the Origin of Life Challenge. John shares this prize of $50,000 -
2012 Francis Crick Lecture to be given by Angelika Amon - MRC…
https://www2.mrc-lmb.cam.ac.uk/2012-francis-crick-lecture-to-be-given-by-angelika-amon/13 Feb 2012: The importance of these characteristics in tumor evolution and development of new treatment strategies will be presented. -
Accolades for Imagining the Brain art competition winners - MRC…
https://www2.mrc-lmb.cam.ac.uk/accolades-for-imagining-the-brain-art-competition-winners/2 Oct 2012: The awards evening also saw the announcement of the new topics for the 2013 competition. -
The proteasome: a vital amino acid recycling machine - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/the-proteasome-a-vital-amino-acid-recycling-machine/19 Oct 2012: The proteasome is essential for the controlled degradation of a large number of unwanted or damaged proteins in all cells and thereby controls virtually -
Link between shape shifting protein and HIV resistance - MRC…
https://www2.mrc-lmb.cam.ac.uk/link-between-shape-shifting-protein-and-hiv-resistance/12 Mar 2012: A group of collaborative researchers, led by Leo James' group in the LMB's PNAC Division, have discovered evidence that helps to explain why primates are -
First high-resolution 3D structure of a DNA origami object - MRC…
https://www2.mrc-lmb.cam.ac.uk/first-high-resolution-3d-structure-of-a-dna-origami-object/21 Nov 2012: However, whereas LEGO blocks are very rigid, researchers thought that these new DNA structures would be jelly-like, flexible structures, thus limiting their use in technological applications. ... The order in this object has been estimated to be -
The sweet way of detecting bacterial invasion in cells - MRC…
https://www2.mrc-lmb.cam.ac.uk/the-sweet-way-of-detecting-bacterial-invasion-in-cells/16 Jan 2012: Felix Randow's group in the LMB's PNAC Division has identified Galectin-8 as a novel danger receptor and factor of the cellular machinery that protects -
Professor Sir Alan Fersht FRS becomes the 42nd Master of Caius - MRC…
https://www2.mrc-lmb.cam.ac.uk/professor-sir-alan-fersht-frs-becomes-the-42nd-master-of-caius/9 Oct 2012: He has pioneered many new fields in protein sciences and is a group leader in the MRC Laboratory of Molecular Biology, Cambridge… This article is no longer available from the source -
Rebecca Voorhees awarded Sir Henry Wellcome Postdoctoral Fellowship - …
https://www2.mrc-lmb.cam.ac.uk/rebecca-voorhees-awarded-sir-henry-wellcome-postdoctoral-fellowship/18 Jul 2012: Dr Rebecca Voorhees, a student and Career Development Fellow at the LMB, has been awarded a Sir Henry Wellcome Postdoctoral Fellowship. The Fellowship -
Novel Mechanism for Regulating Inflammation and Cancer Discovered -…
https://www2.mrc-lmb.cam.ac.uk/novel-mechanism-for-regulating-inflammation-and-cancer-discovered/13 Jan 2012: The work at the LMB shows that if the interaction between iRhom2 and TACE can be blocked with a drug-like molecule, this could lead to a new class of drugs -
Friends of FUS: Protein's Many RNA Buddies Point to Disease - MRC …
https://www2.mrc-lmb.cam.ac.uk/friends-of-fus-proteins-many-rna-buddies-point-to-disease/9 Oct 2012: This work follows another study of FUS targets led by Jernej Ule of the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, U.K., -
Inaugural John Kendrew Lecture to be given by David Drubin - MRC…
https://www2.mrc-lmb.cam.ac.uk/inaugural-john-kendrew-lecture-to-be-given-by-david-drubin/30 Mar 2012: David Drubin, will give the inaugural John Kendrew Lecture on Tuesday 3rd April at 4.15pm in the LMB's Max Perutz Lecture Theatre. The title of the -
Synthetic XNA molecules can evolve and store genetic information -…
https://www2.mrc-lmb.cam.ac.uk/synthetic-xna-molecules-can-evolve-and-store-genetic-information/20 Apr 2012: “Phil Holliger's group has developed six alternative polymers called XNAs that can also store genetic information and evolve through natural -
LMB researcher wins 'Media Fellow' work experience with BBC…
https://www2.mrc-lmb.cam.ac.uk/lmb-researcher-wins-media-fellow-work-experience-with-bbc-horizon/26 Jul 2012: Andrew Holding, from the LMB's Cell Biology division, has been awarded a British Science Association Media Fellowship - giving him the opportunity to work -
Three LMB Scientists receive EMBO Young Investigator Programme Awards …
https://www2.mrc-lmb.cam.ac.uk/three-lmb-scientists-receive-embo-young-investigator-programme-awards/14 Nov 2012: Three LMB scientists, Andrew Carter, Greg Jefferis and Melina Schuh, have been elected into the EMBO Young Investigator Programme for three years, -
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/new_dev…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/new_dev_fs/new_dev_layout.html9 Feb 2012: -
Fruit fly research highlights key mechanism in organ formation - MRC…
https://www2.mrc-lmb.cam.ac.uk/fruit-fly-research-highlights-key-mechanism-in-organ-formation/16 Nov 2012: Katja Röper, Independent Investigator Scientist in the LMB’s Cell Biology Division, has discovered a key mechanism of tissue and organ formation in fruit -
Many Proteins Exist in a State of 'Disorder' and Yet Are…
https://www2.mrc-lmb.cam.ac.uk/many-proteins-exist-in-a-state-of-disorder-and-yet-are-functional/25 Sep 2012: You mention that in the biomedical community disorder is associated with disease. Your co-author M. Madan Babu of the MRC Laboratory of Molecular Biology -
Contents:
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/prosmart/documentation.html12 Jun 2012: Select "Run the Installation Manager to Install a new task", and "Perform automatic installation of tasks into user's local CCP4i area" (if wanting to install for all users, change ... Click "Apply". Restart CCP4i. Note: it may be advisable to uninstall -
Sarah Teichmann to deliver 2012 Francis Crick Lecture for the Royal…
https://www2.mrc-lmb.cam.ac.uk/sarah-teichmann-to-deliver-10th-francis-crick-lecture-for-the-royal-society/19 Nov 2012: Sarah Teichmann, a Group Leader from the Structural Studies Division at the LMB, will deliver the annual Francis Crick Lecture at the Royal Society on 21 -
Data on Cell Biology Described by Researchers at MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/data-on-cell-biology-described-by-researchers-at-mrc-laboratory-of-molecular-biology/12 Jul 2012: Published on. 12 July, 2012. According to news reporting originating in Cambridge, United Kingdom, by NewsRx journalists, researchers stated “CD4+ T cells play key roles in orchestrating adaptive immune responses, and -
Enamine, MRC LMB and IOCB announce collaboration to identify novel…
https://www2.mrc-lmb.cam.ac.uk/enamine-mrc-lmb-and-iocb-announce-collaboration-to-identify-novel-rhomboid-protease-inhibitors/7 Jun 2012: The new alliance is aimed at discovering novel Rhomboid Protease inhibitors as potential drugs to treat infectious, parasitic, oncological, immune and cardiovascular diseases.”Primary Sidebar. -
file:///Users/flong/workplace/balbes_web/MRC-LMB/Webpage/content/balbe…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/documentation_fs/manual_115.pdf9 Feb 2012: Install BALBES under CCP4 Package (replace a old version with a new one). ... Close the old xterms and open new ones. Re-start ccp4i and select BALBES. -
Sub RevComplement() ' ' Set oRng = Selection.Range RevDNA ...
https://www2.mrc-lmb.cam.ac.uk/groups/cartera/download/resources/computer/word_macros/ReverseComplement.doc17 Jan 2012: 1) Open the macros interface. 2) Press Create to make a new macro. -
Autism
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2012/media/ASC.pptx21 Feb 2012: Writing in Pediatrics journal, US researchers followed 862 New Jersey children born at a low birthweight from birth to the age of 21. ... Early Intensive Behavioural Intervention. An important new randomized controlled trial of early intensive -
Getting on your Nerves
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2012/media/GettingOnYourNerves.pptx22 Feb 2012: new ways of controlling inflammation: through electrically stimulating the vagus nerve, by. -
Phil. Trans. Roy. Soc. Lond. B. 261, 95-104 (1971) ...
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/ptrs71.pdf26 Nov 2012: 1964 Fundamentals riftransmission electron microscopy. New York: Interscience. Heidenreich, R. D. & -
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/new_str…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/new_str_pub_fs/new_str_pub_layout.html9 Feb 2012: -
Calcium-mediated Evidence from the Changes in Gap Junction Low ...
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/jcb83.pdf1 Nov 2012: St. Louis, MO); sodium deoxycholate from Calbiochem-Behring Corp. (La Jolla, CA); and HLlabeled sodium deoxycholate (4 Ci/mmol) from New England Nuclear (Boston, MA). -
Model-Building with Coot Paul EmsleyUniversity of Oxford June 2011 ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/aca-2012-low-resolution-scripting-ligands-and-bumps.pdf28 Jul 2012: Overview of Presentation: New algorithms and features Tips on Usage Focus on:. ... Hydrogen tunnelling. Alpha Helix Placement Scenario: Looking at a new map, not built with. -
DOI: 10.1126/science.1229091, 1334 (2012);338 Science et al.P.…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/sciencegayathri2012/Science-2012-Gayathri-1334-7.pdf7 Dec 2012: The title. CopyrightAmerican Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. ... new,higher steady state. -
80096 RPF
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/EMBO2012FtsAPiotr/emboj201276s3.pdf7 Mar 2012: In conclusion, our new data does not provide any insight into this phenomenon. ... We really hope this is clear now – we are certainly very happy with the new data. -
pnas201205508 15259..15264
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/22949682.pdf25 Nov 2012: The synergy of p110αmutants could form the basis for a new class of resistant mutations.The increased affinity of the oncogenic mutants for lipid. -
molcel4221mmc1
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MolCell2012MipZ/mipz2012supp.pdf15 Mar 2012: 2002) PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr 58, 1948-1954. -
Wild card macros
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/sciencegayathri2012/Gayathri.SM.pdf23 Oct 2012: The. symmetry of this new volume was determined by a least-squares fitting algorithm, and this symmetry was imposed. ... upon the reconstruction (35). The new symmetry-enforced volume was used as a reference for the next round of. -
FtsA forms actin-like protofilaments
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/EMBO2012FtsAPiotr/emboj201276a.pdf27 Mar 2012: protofilament architecture (Figures 2A and 3). Inspection of our new FtsA/FtsZ crystal structure. ... in a Beckman TLA100rotor for 30 min, supernatants transferred to new tubes and GTP(in case of FtsZ) or ATP (in case of ParM-Z hybrid) to a -
Regulation of lipid binding underlies the activation mechanism of…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/22120714.pdf21 Nov 2012: The p110 delta structure: mechanisms for selectivity andpotency of new PI(3)K inhibitors. -
Dbouk 1..13
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/vadas_science_signaling.pdf5 Dec 2012: byAssociation for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005. ... cells. Our data suggest that GPCR-mediated activation ofPI3Kb could provide a new target for the design of anticancer therapeutics. -
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS PSTPIP2 deficiency in mice …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Blood-2012-Chitu-3126-35.pdf12 Oct 2012: immune system and has ledto the emergence and rapid development of the new field ofosteoimmunology.32,33 In this paper, we focused on the elucidationof the actions of the anti-inflammatory ... a New York Community Trust Blood Diseases Grant (V.C.);and an
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