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The genetic and developmental basis of morphological and behavioural…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_genetic_and_developmental_basis_of_morphological_and_behavioural_variation_in_cichlid_fishes_no_redacted.pdf30 Apr 2024: We will incorporate new recommendations on animal rearing and welfare as we have done up to now. ... We stay up-to-date with new information and new resources as they become available. -
Mechanisms underpinning neuronal excitability in health and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_underpinning_neuronal_excitability_in_health_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: Results will open avenues to developing new therapies to treat pain and neurodegeneration. ... Have regular discussions with the Named Persons and animal technicians within the facility to review current approaches and whether there are any new 3Rs -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf30 Apr 2024: least 5-10 new anti-cancer drugs using these models, or currently available models. ... Mice are the most common type of animal used for developing new cancer treatments. -
Profiling of test agents in rodents in a drug discovery platform
https://www.ubs.admin.cam.ac.uk/system/files/public/profiling_of_test_agents_in_rodents_in_a_drug_discovery_platform_non-technical_summary_redacted.pdf30 Apr 2024: Ultimately, this project will contribute to the successful development of new drugs, which will benefit patients with the diseases being treated. ... make use of any new knowledge or better methods of performing animal studies. -
Cancer and its microenvironment! From mechanisms to translation…
https://www.ubs.admin.cam.ac.uk/system/files/public/cancer_and_its_microenvironment_from_mechanisms_to_translation_non-technical_summary_redacted.pdf30 Apr 2024: We are following this research field closely and will replace animal research where we can as new technologies develop and are tested and established. ... We also discuss with other groups doing similar research and have an open policy whereby new -
Remodelling of stem cells and niche cells from development and…
https://www.ubs.admin.cam.ac.uk/system/files/public/remodelling_of_stem_cells_and_niche_cells_from_development_and_regeneration_to_disease_non-technic_redacted.pdf30 Apr 2024: By disseminating our observations from early stages, for example via conferences, we create new collaborations with experts in research fields beyond our own. ... We will carry out pilot studies when new substances, radiation doses, or genetically -
CNS Neuron-glia interactions, myelin plasticity, and regeneration, in …
https://www.ubs.admin.cam.ac.uk/system/files/public/cns_neuron-glia_interactions_myelin_plasticity_and_regeneration_in_health_and_disease_non-techni_redacted.pdf30 Apr 2024: The outputs of this licence will likely result in a new information and publications of the following:. ... With this knowledge gained we can identify new testable pathways for augmenting regeneration. -
Environmental and placental contributions to pregnancy and life-long…
https://www.ubs.admin.cam.ac.uk/system/files/public/environmental_and_placental_contributions_to_pregnancy_and_life-long_health_non-technical_summary_redacted.pdf29 Apr 2024: activities including publications in magazines, news articles, blogs, and via twitter / social media feeds. ... We will perform pilot experiments, for e.g. to check the effectiveness of new therapies. -
Generation and screening of companion animal therapeutics.…
https://www.ubs.admin.cam.ac.uk/system/files/public/generation_and_screening_of_companion_animal_therapeutics._non-technical_summary_redacted.pdf30 Apr 2024: Monoclonal antibodies are expected to become a new standard of care in veterinary medicine. ... In order to predict protein structures and design new proteins, large language models (LLMs) are used. -
Biobehavioural basis of the individual vunerability to impulsive…
https://www.ubs.admin.cam.ac.uk/system/files/public/biobehavioural_basis_of_the_individual_vulnerability_to_impulsivecompulsive_spectrum_disorders_redacted.pdf29 Apr 2024: Similarly, it would not be possible to develop new treatments for brain disorders without testing them in animal models first. ... Any new procedure, or combination of procedures, used under this project licence will systematically be previously
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