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Epigenetic inheritence and the control of developmental and…
https://www.ubs.admin.cam.ac.uk/system/files/public/epigenetic_inheritance_and_the_control_of_developmental_and_physiological_processes_non-technical_s_redacted.pdf30 Apr 2024: This means that others do not need to generate new mutants or samples, minimising animal numbers. ... For any new procedures we will review published protocols from experienced collaborators before conducting any experiments. -
Embryonic origins of heart disease
https://www.ubs.admin.cam.ac.uk/system/files/public/embryonic_origins_of_heart_disease_non-technical_summary_redacted.pdf29 Apr 2024: The new bedding material generated much less dust. What published best practice guidance will you follow to ensure experiments are conducted inthe most refined way? ... Therefore, the project licence holder will have regular discussions with the Named -
Understanding the cell biology behind cardiovascular diseases…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf30 Apr 2024: In new systems pilot studies are utilised to ensure the system works as intended with a small group (e.g. ... Mice would also be habitualised to a new restraint before, e.g., BP measurement. -
Regulation of the mammalian reproductive axis
https://www.ubs.admin.cam.ac.uk/system/files/public/regulation_of_the_mammalian_reproductive_axis._non-technical_summary_redacted.pdf30 Apr 2024: until we require new offspring. ... I will also have regular discussions with the Named Persons and animal technicians to review current approaches and whether there are any new 3R opportunities. -
Tissue response following synovial joint injury and potential for…
https://www.ubs.admin.cam.ac.uk/system/files/public/tissue_response_following_synovial_joint_injury_and_potential_for_therapies_to_restore_joint_structu_redacted.pdf30 Apr 2024: These new discoveries will be shared with others at local, national and international scientific meetings and in widely available publications. ... In more detail, it is our expectation that our research will produce one new. -
Exploring Bioelectronic Approaches to Nervous System Restoration in…
https://www.ubs.admin.cam.ac.uk/system/files/public/exploring_bioelectronic_approaches_to_nervous_system_restoration_in_large_animals_non-technical_sum_redacted.pdf30 Apr 2024: Also, these devices will help us learn more about these diseases and might help find even more new treatments. ... Subscribing to the NC3Rs newsletter (https://www.nc3rs.org.uk/news) to receive regular updates on new ideas and research related to the 3Rs. -
Molecular mechanisms of tolerance and immunosuppression…
https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_tolerance_and_immunosuppression_non-technical_summary_redacted.pdf30 Apr 2024: Both are important immunological processes and targets for the development of new drugs. ... There is a great unmet clinical need in this area and our experiments could inform the development of new therapeutics. -
Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …
https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf30 Apr 2024: The treatments that are validated in the project may include new intellectual property. ... Altogether, these will generate a blueprint for clinical studies, which will bring successful new treatments to patients. -
Mouse developmental genetics to study neurodevelopment and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/mouse_developmental_genetics_to_study_neurodevelopment_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: suffer from traumatic brain injuries and 14 million new incidents of stroke globally, each year. ... may require the generation of new transgenic animals, therefore reducing the number of animals needed to fulfil the objectives we set up in this license. -
The development of in vivo expressed biologics as a platform for…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf30 Apr 2024: Therefore there is a clear need to pioneer new medical treatments and technologies to address this increasing disease burden. ... This will inform specific drug projects that are aiming to produce new medicines for patients.
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