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30 Apr 2024: Any new drug development can take up to 10-12 years before it can be used on human patients. ... We have developed a new method where we can screen antibody secreting B-cells directly for antigen binding.

29 Apr 2024: Supervisors teaching new PILs will do so following LASA guiding principles to ensure new users are properly trained to perform any procedures necessary. ... Supervisors teaching new licence holders will do so following LASA guiding principles to ensure

30 Apr 2024: In the long-term we hope that this work will lead to translational outputs in the form of clinical trials around new therapeutic agents. ... establishing a new colony of mice from frozen eggs and/or sperm) any further strains of mice we need for this

30 Apr 2024: They enable us to test the effect of new treatments in a relevant and intact biological system. ... This project will provide important information to progress new treatments through the phases of drug development.

30 Apr 2024: There is an urgent need for new drugs and therapies to slow, delay and prevent proteinopathy diseases. ... Overall, we hope to identify new genes and compounds that allow us to better understand and manipulate neurodegeneration.

30 Apr 2024: Finally, full training will be provided to new technicians who are unfamiliar with these procedures. ... This will ensure that we maintain compliance should any new updates be posted.

30 Apr 2024: As new molecular targets involved in diseases are discovered, the imaging agents that are required for imaging them need to be developed and evaluated in a manner similar to the drug ... When new drugs for removing these proteins are being developed it

29 Apr 2024: On rare occasions, a new drug being tested can have unexpected adverse effects. ... Pilot studies will be employed when first attempting growth of a new source of human immune cells.

29 Apr 2024: New knowledge will be disseminated in. PPL number: | Granted: 17 Feb 23 | Amended: 23 Aug 23 | Expires: 17 Feb 28. ... The majority of our vaccine studies can be considered "pilot studies" as we are measuring immune responses to new vaccines.

30 Apr 2024: Knowledge generated from this work will open new avenues to eradicate whipworm and hookworm infections and control immune-mediated diseases. ... By the end of this project, we will have new information on the host-whipworm relationship, including (1) how

30 Apr 2024: Therefore, the proposed work in this new project licence may hasten translation to relatively simple but novel human clinical interventions to not only treat the mother, but also her progeny. ... Therefore, the project licence holder will have regular

30 Apr 2024: We will generate new insight into the major biological processes underlying inflammatory diseases. ... This enables the development of new therapeutics, exploiting our discoveries. Species and numbers of animals expected to be used.

30 Apr 2024: This project will provide important information that aids the progression of new drugs against bleeding disorders through the drug discovery and development process. ... for our studies and to identify any new and better methods that could be utilised.

30 Apr 2024: We will incorporate new recommendations on animal rearing and welfare as we have done up to now. ... We stay up-to-date with new information and new resources as they become available.

30 Apr 2024: This project will generate important data in the preclinical development of potential new drugs for metabolic and cardiovascular disease. ... This will include investigation of any potential unwanted side effects that could be caused by the new drugs.

30 Apr 2024: Results will open avenues to developing new therapies to treat pain and neurodegeneration. ... Have regular discussions with the Named Persons and animal technicians within the facility to review current approaches and whether there are any new 3Rs

30 Apr 2024: Ultimately, this project will contribute to the successful development of new drugs, which will benefit patients with the diseases being treated. ... make use of any new knowledge or better methods of performing animal studies.

30 Apr 2024: By disseminating our observations from early stages, for example via conferences, we create new collaborations with experts in research fields beyond our own. ... We will carry out pilot studies when new substances, radiation doses, or genetically

30 Apr 2024: least 5-10 new anti-cancer drugs using these models, or currently available models. ... Mice are the most common type of animal used for developing new cancer treatments.

30 Apr 2024: We are following this research field closely and will replace animal research where we can as new technologies develop and are tested and established. ... We also discuss with other groups doing similar research and have an open policy whereby new