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3Rs Minutes 3rd February 2021 Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_030221_redacted.pdf14 May 2024: The committee were pleased to see refinements previously developed with collaborators being brought forward into this new licence. • -
AWERB Sub-Standing Committee Meeting Minutes - 8th November 2023
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_081123_redacted.pdf17 Jan 2024: around the new proposed protocol. • Further review of Protocol 6 required to ensure all sections have the correct severity. • -
Developing new mulivalent recombinant vaccines platforms against…
https://www.ubs.admin.cam.ac.uk/system/files/public/developing_new_multivalent_recombinant_vaccines_platforms_against_infectious_diseases._non-technic_redacted.pdf29 Apr 2024: What's the aim of this project? The overall aim of the research is to develop new and improved vaccines. ... New vaccines need to be safe, well tolerated, effective and offer broad coverage against many pathogens. -
Axon degeneration and repair (non-technical summary)
https://www.ubs.admin.cam.ac.uk/system/files/public/axon_degeneration_and_repair_non-technical_summary_redacted.pdf30 Apr 2024: Our plan is to publish research papers with new information on which human diseases involve programmed axon death and which specific people are most at risk. ... As we have shown, when a new 3Rs method becomes available (e.g., hiPSC-derived neurons), we -
Placental epignetic programming
https://www.ubs.admin.cam.ac.uk/system/files/public/placental_epigenetic_programming_non-technical_summary_redacted.pdf30 Apr 2024: Our findings will help both clinical and basic science research in reproductive biology and epigenetics to generate new research questions. ... Culture methods for human placental trophoblast cells are very new and still under development. -
Early human development and the germline (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/early_human_development_and_the_germline_non-technical_summary_redacted.pdf30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and ... We have reduced significantly the number of mice -
Cartilage repair and replacement
https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf29 Apr 2024: Animals will be brought in and allowed to acclimatise for a few weeks - this helps them to relax in their new surroundings, gets them used to the staff and human contact ... bones, which acts as a shock absorber), to which the new implant/therapy will be -
New treatments for renal and liver disease (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf30 Apr 2024: In work under this licence we aim to identify new treatments for CKD, AKI and NAFLD. ... project? We hope to optimise new imaging efficacy endpoints that will allow assessment of animals over time. -
In vivo compressive forces (non-technical summary)_Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf30 Apr 2024: For each stock a new generation will be grown every 18 months (3.3 generations per line in 5 years). ... For each we will breed a new generation every 18 months (2560x3.3=8448). -
Models of mitochondrial diseases, pathogenesis and therapy
https://www.ubs.admin.cam.ac.uk/system/files/public/models_of_mitochondrial_diseases_pathogenesis_and_therapy_non-technical_summary_redacted.pdf30 Apr 2024: 1. New mouse models of mitochondrial disease which carry mutations similar to those found in humans. ... The remaining 20% will be neonates (new born pups up to weaning - approx.
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