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New drug target for asthma - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/new-drug-target-asthma/13 Oct 2016: Search this website. New drug target for asthma. New drug target for asthma. ... Published on. 13 October, 2016. A new therapeutic target for inflammatory diseases such as asthma and autoimmune disorders has been identified by scientists at the Wellcome -
New microscope lens: top ten breakthroughs - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/new-microscope-lens-top-ten-breakthroughs/13 Dec 2016: Search this website. New microscope lens: top ten breakthroughs. New microscope lens: top ten breakthroughs. ... Ten Breakthroughs of 2016, for creating a new microscope lens that offers the unique combination of a large field of view with high resolution -
NBLAST – a new online tool to compare neurons - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/nblast-new-online-tool-compare-neurons/20 Jul 2016: 20 July, 2016. Researchers in Greg Jefferis’s group in the LMB’s Neurobiology Division have developed a new online tool to analyse images of neurons. ... NBLAST is already proving useful in fly brain research to identify neuron types, organize large -
New hypothesis for the formation of macropinocytic cups - MRC…
https://www2.mrc-lmb.cam.ac.uk/new-hypothesis-formation-macropinocytic-cups/14 Dec 2016: New hypothesis for the formation of macropinocytic cups. Published on. 14 December, 2016. ... the USA and Robert Insall at the Beatson Institute in Glasgow, has resulted in the formation of a new hypothesis for how these cups form. -
LMB welcomes Joseph Yeeles as new Group Leader - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/lmb-welcomes-joseph-yeeles-new-group-leader/11 Jul 2016: LMB welcomes Joseph Yeeles as new Group Leader. Published on. 11 July, 2016. ... Our development of a reconstituted eukaryotic replication system provides exciting new opportunities to investigate mechanisms of chromosome replication in ways that were -
Artificial DNA could build new generation of cancer drugs - MRC…
https://www2.mrc-lmb.cam.ac.uk/artificial-dna-build-new-generation-cancer-drugs/12 Apr 2016: Search this website. Artificial DNA could build new generation of cancer drugs. ... Artificial DNA could build new generation of cancer drugs. Published on. -
LMB welcomes Emmanuel Derivery as new Group Leader - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/lmb-welcomes-emmanuel-derivery-new-group-leader/17 Nov 2016: Search this website. LMB welcomes Emmanuel Derivery as new Group Leader. ... LMB welcomes Emmanuel Derivery as new Group Leader. Published on. 17 November, 2016. -
Epigenetic instability
https://www2.mrc-lmb.cam.ac.uk/groups/jes/epigeninst.html2 Sep 2016: Thus parental H3/4 tetramers are interspersed with newly synthesised H3/4. Most of the time, the old and new proteins are not mixed within the same nucleosome. ... In DT40 cells lacking Rev1, certain normally repressed genes containing G quadruplex DNA -
New insights into the mechanism of ubiquitin chain cleavage - MRC…
https://www2.mrc-lmb.cam.ac.uk/new-insights-mechanism-ubiquitin-chain-cleavage/13 Oct 2016: This has given unprecedented insight into the catalytic mechanism of a DUB and revealed a new mechanism of how ubiquitin chains can be cleaved. ... The new understanding of the catalytic process in deubiquitinases will become a key reference point for -
New technologies enable systematic recoding of genomes - MRC…
https://www2.mrc-lmb.cam.ac.uk/new-technologies-enable-systematic-recoding-genomes/24 Oct 2016: Search this website. New technologies enable systematic recoding of genomes. New technologies enable systematic recoding of genomes. ... Using these new techniques they attempted systematic recoding of the genomic sequence in an essential operon using -
Cryo-EM sheds new light on the spliceosome activation process - MRC…
https://www2.mrc-lmb.cam.ac.uk/cryo-em-sheds-new-light-on-the-spliceosome-activation-process/1 Feb 2016: Search this website. Cryo-EM sheds new light on the spliceosome activation process. ... Cryo-EM sheds new light on the spliceosome activation process. Published on. -
Structural insight offers potential for new anti-malarial treatment - …
https://www2.mrc-lmb.cam.ac.uk/structural-insight-offers-potential-for-new-anti-malarial-treatment/11 Feb 2016: Structural insight offers potential for new anti-malarial treatment. Published on. 11 February, 2016. . ... falciparum proteasome and used this information to design a new compound with promising anti-malarial properties. -
Suffrage Science Scheme Award for Lori Passmore - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/suffrage-science-scheme-award-lori-passmore/9 Mar 2016: She is also developing new methods with cryo-EM to help determine protein structure, including the development of new specimen grids made of pure gold, that improve the quality of -
From Parkinson’s Disease to ubiquitin - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/parkinsons-disease-ubiquitin/29 Mar 2016: LMB, on a journey to cast surprising new light on the universal cellular ubiquitin modification system (page 9) More…. -
Interview with Richard Henderson - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/interview-richard-henderson/27 Jun 2016: The winner of the Copley Medal talks structural biology, fixing cars and sleeping soundly. More... -
Soft Landings Project: The MRC LMB - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/soft-landings-project-mrc-lmb/16 Jun 2016: Published on. 16 June, 2016. Details of the Soft Landings project for the new LMB building, including a summary of the building’s special features, the design and construction process and -
Knighthood for Richard Treisman - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/knighthood-richard-treisman/13 Jun 2016: Richard Treisman, biochemist, molecular biologist and Research Director at the Francis Crick Institute, has been knighted in the Queen's Birthday Honours -
Why brains are beautiful - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/why-brains-are-beautiful/17 Feb 2016: How advances in neuroscience, including LMB's Madeline Lancaster's work on 'mini-brains', are helping to unlock the secrets of this biological masterpiece -
Recovering stalled ribosomes - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/recovering-stalled-ribosomes/8 Dec 2016: Now researchers in the LMB’s Structural Studies and Cell Biology divisions have used electron cryomicroscopy (cryo-EM) to reveal new insights into these mechanisms. ... It is hoped that these new insights will enrich our understanding of the -
Cambridge's 92 Nobel Prize winners - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/cambridges-92-nobel-prize-winners/2 Feb 2016: Published on. 2 February, 2016. Cambridge News’ has been rounding up all of Cambridge’s 92 Nobel Laureates, which includes 15 LMB scientists: 13 whose Nobel Prize winning research was conducted ... These articles are no longer available from the -
Structure of the catalytic spliceosome - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/structure-catalytic-spliceosome/26 Jul 2016: This has provided important mechanistic insights into RNA-based splicing catalysis. It has consolidated nearly three decades of biochemistry and genetics on the spliceosome and indicates new research directions to be -
HIV Research Breakthroughs 2016 - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/hiv-research-breakthroughs-2016/19 Dec 2016: Medical Daily includes work by the LMB's Leo James's group and University College London on improving antiviral drugs as one of its HIV research -
Microscopy: Imaging far and wide - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/microscopy-imaging-far-wide/6 Oct 2016: A custom-built objective lens called the Mesolens allows relatively large biological specimens to be imaged with cellular resolution. It was developed by -
Community apple tree project at the LMB - MRC Laboratory of Molecular …
https://www2.mrc-lmb.cam.ac.uk/community-apple-tree-project-lmb/19 Dec 2016: area. The planting of the trees will provide a unique linear orchard that marks the routes between the new developments south of the city and the city centre. -
Venki Ramakrishnan: The Life Scientific - MRC Laboratory of Molecular …
https://www2.mrc-lmb.cam.ac.uk/venki-ramakrishnan-life-scientific/10 Mar 2016: Venki talks about his life and work for BBC Radio 4's The Life Scientific. More... -
Jernej Ule and Ian Tomlinson elected to EMBO - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/jernej-ule-ian-tomlinson-elected-embo/24 May 2016: Two former LMB group leaders have been named as new EMBO members. ... Jernej and Ian are among 58 new members to join EMBO, who elect new members annually on the basis of scientific excellence and outstanding research contributions. -
Entertaining the crowds at Soapbox Science, Cambridge - MRC…
https://www2.mrc-lmb.cam.ac.uk/entertaining-crowds-soapbox-science-cambridge/6 Jul 2016: The LMB’s Danielle Mersch and Nicola Smyllie along with other leading female scientists from the region took to their soapboxes on Saturday 2nd July in -
The Author File: Jason W. Chin - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/the-author-file-jason-w-chin/29 Jan 2016: How to combine biology, chemistry and synthetic biology to add synthetic amino acids to a protein, and why creativity matters. Profile of LMB group -
Greg Jefferis becomes FENS Kavli Scholar - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/greg-jefferis-becomes-fens-kavli-scholar/7 Jul 2016: Published on. 7 July, 2016. LMB Group Leader, Greg Jefferis, has been elected as one of 15 new FENS Kavli Scholars. -
Katja Röper: Deciphering tissue origami - MRC Laboratory of Molecular …
https://www2.mrc-lmb.cam.ac.uk/katja-roper-deciphering-tissue-origami/25 Oct 2016: Profile of LMB group leader Katja Röper and her work on how cytoskeletal behaviour controls tissue morphogenesis. More... -
UTCC students have hands-on EM experience at the LMB - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/utcc-students-hands-em-experience-lmb/1 Dec 2016: The LMB has continued its collaboration with the University Technical College Cambridge (UTCC), with students visiting as part of their microscopy -
Allergan signs $3.3bn deal with Heptares - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/allergan-signs-3-3bn-deal-heptares/13 Apr 2016: Heptares Therapeutics, an LMB spin-out company, announces a deal with Allergan for development of novel treatments for neurological disorders, including -
Cell scientist to watch - Sabine Petry - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/cell-scientist-watch-sabine-petry/17 Nov 2016: Sabine Petry, LMB 2003-2007, PhD Student, Structural Studies Originally from Germany, Sabine received her Diploma (MSc) from Goethe University and -
Master of Trinity's Bicycle worth up to $1 billion - MRC…
https://www2.mrc-lmb.cam.ac.uk/master-trinitys-bicycle-worth-1-billion/6 Dec 2016: Bicycle is pioneering a new class of drugs based on its bicyclic peptide platform, and will be working with AZ to spot and develop new treatments for respiratory, cardiovascular and metabolic -
Melina Schuh’s Lister Research Prize Lecture - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/melina-schuhs-lister-research-prize-lecture/30 Jun 2016: Published on. 30 June, 2016. Melina Schuh, former Group Leader in the LMB’s Cell Biology Division, will deliver her Lister Prize lecture, “New insights into aneuploidy in human oocytes”, on -
Greg Winter receives Prince Mahidol Award - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/greg-winter-receives-prince-mahidol-award/22 Nov 2016: Monoclonal antibodies now account for a third of all new treatments and provide therapy for a diverse array of diseases from breast cancer to arthritis. -
Behind the picture: a tiny cell-killing drill - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/behind-picture-tiny-cell-killing-drill/3 May 2016: Christos Savva, Electron Microscopy Facility scientist at the LMB, talks about why understanding structures of important proteins could be the key to -
Mighty Molecular Motors at the Big Biology Day - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/mighty-molecular-motors-big-biology-day/7 Nov 2016: It gave me a new perspective to our work in the lab and I’m looking forward to next time!”. -
LMB raises £378 at Macmillan Coffee Morning - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/lmb-raises-378-macmillan-coffee-morning/19 Oct 2016: For the second year running, the LMB’s HR team, supported by colleagues across the LMB, showed off their baking skills for the Macmillan Cancer Support -
LMB raises over £1500 for The British Heart Foundation - MRC…
https://www2.mrc-lmb.cam.ac.uk/lmb-raises-1500-british-heart-foundation/19 Dec 2016: Over £1500 has been raised by LMB staff for The British Heart Foundation (BHF) at the annual charity Christmas raffle. The BHF was chosen in memory of -
Cambridge Pharmaceutical Cryo-EM Consortium - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/cambridge-pharmaceutical-cryo-em-consortium/5 Apr 2016: Cambridge Pharmaceutical Cryo-EM Consortium formed by FEI, five pharmaceutical companies, LMB and the University of Cambridge. Sample preparation and data -
An open translocation channel revealed - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/an-open-translocation-channel-revealed/4 Jan 2016: The new structure provides the first high resolution view of an open and functioning protein conducting channel. ... By comparing the new Sec61 structure to these previous structures, they have predicted a two-step mechanism for how the channel might be -
Ramanujan Hegde elected Fellow of the Royal Society - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/ramanujan-hegde-elected-fellow-royal-society/29 Apr 2016: Each year, the Royal Society elects up to 52 new Fellows and up to ten new Foreign Members, recognising those scientists who have made substantial contributions to the improvement of knowledge -
Augmenting CRISPR genome editing applications - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/augmenting-crispr-genome-editing-applications/6 Sep 2016: Published on. 6 September, 2016. The ability of scientists to create changes in gene sequences has improved dramatically in recent years with the emergence of a new method, dubbed ‘CRISPR’. ... This new approach was inspired by work in rice, which -
Madeline Lancaster - The genius who grows tiny brains. - MRC…
https://www2.mrc-lmb.cam.ac.uk/madeline-lancaster-genius-grows-tiny-brains/28 Sep 2016: Our brains are complex organic computers – some believe the most complicated in the Universe. Yet one scientist has managed to create mini brains that -
LMB rides to victory in National Cycle Challenge - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/lmb-rides-victory-national-cycle-challenge/25 Oct 2016: The LMB has continued its winning cycling record by taking first place in its category in the Love to Ride Cambridgeshire event – part of the National -
HIV: Newly discovered component could lead to more effective drugs. - …
https://www2.mrc-lmb.cam.ac.uk/hiv-newly-discovered-component-lead-effective-drugs/16 Aug 2016: 16 August, 2016. Collaborative research between Leo James’s group and colleagues at UCL has uncovered key components of HIV, which they believe could lead to new approaches for drugs to -
Structure of brain receptor linked to learning - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/structure-brain-receptor-linked-learning/11 Mar 2016: In addition, AMPA receptors are drug targets and the new structure offers development to novel protein interfaces of the receptor. -
Nanostructures from synthetic genetic polymers - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/nanostructures-synthetic-genetic-polymers/18 Mar 2016: 'Synthetic biology' is a scientific approach that seeks to answer fundamental questions in biology by reconstruction and modification of the molecules and -
LMB scientists talk at the Cambridge Science Festival - MRC…
https://www2.mrc-lmb.cam.ac.uk/lmb-scientists-talk-cambridge-science-festival/23 Mar 2016: As part of the Cambridge Science Festival, two of the LMB’s group leaders talked to the public about their research at the University Technical College
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