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  2. AOC Minutes 25th February 2022

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_25.02.22_redacted.pdf
    14 May 2024: The Home Office has asked for a report after every new and amended PPL has gone through an AWERB meeting. ... The Guildhall has pulled out due to building work and the new location is yet to be confirmed.
  3. AOC Minutes 17th February 2023

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_170223_redacted.pdf
    17 Jan 2024: 2. Matters Arising. asked everyone to introduce themselves as there are new staff members in attendance. ... Thank you to everyone who is using the new template and RCA email address.
  4. AOC Minutes 230623

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_230623_redacted.pdf
    23 Jan 2024: Also welcome to the new UBS Admin Assistant who started 2 weeks ago. ... A new area has been created to accommodate this. Some comments around runting and animals being marked as small have now been split to allow small to refer to adults.
  5. AWERB Standing Minutes 27th March 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_270324_redacted.pdf
    30 Apr 2024: Project Licences (a) New licence: was also in attendance) The committee discussed the following:. • ... Page 2 of 4. (b) New Licence: was also in attendance) The committee discussed the following:. •
  6. AWERB Standing Committee Meeting Minutes 18th December 2023

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_181223_redacted.pdf
    28 Feb 2024: Project Licences (a) New licence: The committee discussed the following:. • Further consideration should be given to the lay person in regards to the Non-Technical Summary and this should also be
  7. 3Rs Minutes 7th April 2021 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_070421_redacted.pdf
    14 May 2024: The 3Rs Committee wish all the best for her new job in The Netherlands. •
  8. 3Rs Minutes 3rd February 2021 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_030221_redacted.pdf
    14 May 2024: The committee were pleased to see refinements previously developed with collaborators being brought forward into this new licence. •
  9. AWERB Sub-Standing Committee Meeting Minutes - 8th November 2023

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_sub-standing_minutes_081123_redacted.pdf
    17 Jan 2024: around the new proposed protocol. • Further review of Protocol 6 required to ensure all sections have the correct severity. •
  10. Developing new mulivalent recombinant vaccines platforms against…

    https://www.ubs.admin.cam.ac.uk/system/files/public/developing_new_multivalent_recombinant_vaccines_platforms_against_infectious_diseases._non-technic_redacted.pdf
    29 Apr 2024: What's the aim of this project? The overall aim of the research is to develop new and improved vaccines. ... New vaccines need to be safe, well tolerated, effective and offer broad coverage against many pathogens.
  11. Axon degeneration and repair (non-technical summary)

    https://www.ubs.admin.cam.ac.uk/system/files/public/axon_degeneration_and_repair_non-technical_summary_redacted.pdf
    30 Apr 2024: Our plan is to publish research papers with new information on which human diseases involve programmed axon death and which specific people are most at risk. ... As we have shown, when a new 3Rs method becomes available (e.g., hiPSC-derived neurons), we
  12. Placental epignetic programming

    https://www.ubs.admin.cam.ac.uk/system/files/public/placental_epigenetic_programming_non-technical_summary_redacted.pdf
    30 Apr 2024: Our findings will help both clinical and basic science research in reproductive biology and epigenetics to generate new research questions. ... Culture methods for human placental trophoblast cells are very new and still under development.
  13. Early human development and the germline (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/early_human_development_and_the_germline_non-technical_summary_redacted.pdf
    30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and ... We have reduced significantly the number of mice
  14. Cartilage repair and replacement

    https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf
    29 Apr 2024: Animals will be brought in and allowed to acclimatise for a few weeks - this helps them to relax in their new surroundings, gets them used to the staff and human contact ... bones, which acts as a shock absorber), to which the new implant/therapy will be
  15. New treatments for renal and liver disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: In work under this licence we aim to identify new treatments for CKD, AKI and NAFLD. ... project? We hope to optimise new imaging efficacy endpoints that will allow assessment of animals over time.
  16. In vivo compressive forces (non-technical summary)_Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf
    30 Apr 2024: For each stock a new generation will be grown every 18 months (3.3 generations per line in 5 years). ... For each we will breed a new generation every 18 months (2560x3.3=8448).
  17. Models of mitochondrial diseases, pathogenesis and therapy

    https://www.ubs.admin.cam.ac.uk/system/files/public/models_of_mitochondrial_diseases_pathogenesis_and_therapy_non-technical_summary_redacted.pdf
    30 Apr 2024: 1. New mouse models of mitochondrial disease which carry mutations similar to those found in humans. ... The remaining 20% will be neonates (new born pups up to weaning - approx.
  18. Mechanisms controlling cell division and cell identity during…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_controlling_cell_division_and_cell_identity_during_development_reprogramming_and_disease_redacted.pdf
    30 Apr 2024: For example, understanding how cell identity can contribute to diseases may help in the discovery of new treatments. ... I am currently on the European Xenopus Resource Steering Committee where new developments in frog husbandry are often discussed.
  19. Understanding Infection Pathogenesis to Guide Therapies…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf
    30 Apr 2024: 6.1 million deaths annually (https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). ... This is confounded by the fact that there have been very few new antimicrobial products that have been developed over the last 15 years.
  20. Mechanisms of organ development and disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_of_organ_development_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.
  21. Interaction between the immune system and tumours (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/interaction_between_the_immune_system_and_tumours_non-technical_summary_redacted.pdf
    30 Apr 2024: To the wider pharmaceutical industry and patients this could lead into the development of new anti-cancer therapies. ... Pilot studies are used to establish the correct dose of reagents/cells, timelines, and to generate baseline data for new experiments.

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