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13 Sep 2021: The plan is to generate approximately 10 new models over the course of the licence. ... In this licence we will use lung tumour models to investigate new potential drugs for the treatment of lung cancer.

13 Sep 2021: To develop new drugs, it is first necessary to better understand how the nervous system works and what goes wrong in disease: enhanced understanding of how neurones work in health and ... With enhanced knowledge, our work will aid the development of new

20 Aug 2021: Importantly, we will study the relationship between the hippocampus (the area of the brain which acts as an internal GPS system and is crucial for remembering new events and navigating) and

20 Aug 2021: Given how little innovation there is in veterinary medicine (compared to human medicine), this new class of drugs could have an even bigger impact on pet health than it did on ... In summary: Short-term benefit – New veterinary medicines based on what

13 Sep 2021: For colorectal endoscopic courses, procedures may include a range of new surgical bowel procedures. ... For upper GI endoscopic courses procedures may include tonsillectomy, oesophageal, stomach, duodenal or pancreatic surgery, or other new appropriate

19 Aug 2021: The treatments that come out of the project may be new intellectual property. ... Altogether, these will generate a blueprint for clinical studies, which will bring successful new treatments to patients.

20 Aug 2021: To avoid breeding new mouse strains we will investigate specific immune cells that are labelled.

19 Aug 2021: With all this information, new clinical trials can be designed that eventually may change clinical practice. ... They are also required by regulatory authorities before any trials of new drugs can be tested in humans.

20 Aug 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Evaluation of new devices to be used in humansurgery. ... Also, getting new, effective devices/compounds into clinical use as quickly and safely as possible will maximise patient benefits and healthcare savings.

19 Aug 2021: for pilot studies (https://www.nc3rs.org.uk/conducting-pilot-study);. ARRIVE guidelines, https://www.nc3rs.org.uk/arrive-guidelines;. IMPROVE guidelines for stroke models: ... I receive regular updates via the Biological Service of the University of

13 Sep 2021: We will perform pilot studies testing any new therapies in very small groups of normal mice. ... These new therapies will have already been tested in isolated cells in the laboratory.

19 Aug 2021: We hope this will help find new ways to treat or prevent brain disease. ... However, when we develop new techniques, we carefully consider the literature and seek expert advice before starting.

18 Jun 2021: Page 3 of 10. New genes of interest will be identified and described. ... Thus, finding new biomarkers improves our ability to both detect and treat cancer.

19 Aug 2021: These papers will describe the development of a new type of bone repair material. ... the structure may be compromised, while if it too slow it may adversely affect new bone formation.

19 Aug 2021: basal skin layer, the productive life cycle is triggered and new viruses are produced; iv) PV is shed inside dead cells from the surface of. ... new insight into PV transmission mechanisms, and the development of anti-papillomavirus agents/treatments and

18 Jun 2021: The new insights gained could lead to new strategies for treating such disorders, including learning disabilities and Alzheimer's disease. ... Moreover, our institution's web pages provide regular updates on new developments in the 3Rs.

13 Sep 2021: What's the aim of this project? This project aims to discover and develop new ways to treat or prevent malaria transmission and disease. ... As such, the development of new anti-malaria blocking strategies is a major objective.

13 Sep 2021: In order to produce new mouse colonies a minority of germ-free mice will be given mammalian gut bacteria orally to produce gnotobiotic mice with a known gut flora (bacteria).

19 Aug 2021: The long-term goal of this research is to discover new mechanisms controlling the growth of nerve cells.

13 Sep 2021: The research will aid in the development of new bacterial therapies to treat cancer. ... We continuously consider their use and development in light of new experimental data.

18 Jun 2021: This network will be utilised to maximise the dissemination of the new knowledge gained through this project. ... 3) By generating large quantities of human cells, where appropriate, we can continue to perform new studies using the same human cells.

13 Sep 2021: The new insights gained could lead to new strategies for treating such disorders, including learning disabilities and Alzheimer's disease. ... Moreover, our institution's web pages provide regular updates on new developments in the 3Rs.

18 Jun 2021: tolerance, providing new information on how the genes under investigation impact human metabolism and health. ... or 'negative' in the same way that a trial of a new treatment would be.

18 Jun 2021: The work will;. 1. Provide new insights into the mechanisms required for regeneration. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

18 Jun 2021: This project will likely result in new information and publications about the following:. ... In recent years scientists have developed a new way of growing (culturing) cells in 3 dimensions.

13 Sep 2021: This second part will provide new hypotheses and research avenues for future research projects about mitochondrial and neurodegenerative diseases. ... Data generated from this project will form the basis for new funding applications, and may eventually

13 Sep 2021: Our investigations and the data generated are expected to lead to new collaborations with other researchers. ... We will incorporate new recommendations on animal welfare, as soon as possible after their publication.

18 Jun 2021: We aim to develop new approaches to treatment that target the pathways identified from human genetic studies. ... We will disseminate new knowledge and findings by publishing our results in internationally recognised scientific journals.

13 Sep 2021: However, our understanding of how this happens is still limited, and this has prevented scientists from finding new effective treatments. ... Our results will therefore benefit the scientific community through the provision of important new knowledge

18 Jun 2021: We expect to test new compounds that inhibit alpha-synuclein aggregation into clumps and spreading to delay the development of pathology. ... Several collaborations are in place and will be developed to obtain new tools to further the understanding of

13 Sep 2021: Chiefly, outputs will include generation of new knowledge, which will be timely and freely disseminated as publications in open-access journals, full datasets, and conference presentations. ... Before behavioural testing, mice will be acclimatised to the

19 Aug 2021: Animals from these new lines will be used to generate eggs by natural spawning. ... In the case of new chemicals, pilot experiments will be used to test chemical toxicity.

18 Jun 2021: We are using new-born mice to collect cells to grow and keep in a dish to do experiments. ... provide additional sources of new recommendations and advances in animal techniques and clinically applicable models.

13 Sep 2021: All new information will be presented at scientific conferences and published as peer-reviewed research articles. ... When repeated or prolonged interventions are required, animals will be acclimitised to new environments (e.g.

13 Sep 2021: Hence, there is an urgent need for new and safe drugs that successfully reverses or prevents progression of liver injury in patients with NASH. ... Page 4 of 7. By researching on new targets for such related diseases is a clear unmet clinical need.

18 Jun 2021: Chiefly, we are interested in developing new understanding of nutrient signalling (e.g. ... As such, our work may highlight new uses for existing compounds or indicate new targets for future compounds.

13 Sep 2021: The work will;. 1. Provide new insights into the mechanisms required for regeneration. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

13 Sep 2021: fostering of new international collaborations that will allow new approaches to current and future scientific questions. - ... Subsequently, the new mouse line would be used to obtain embryos for the experiments as described above.

13 Sep 2021: It is estimated that by 2040 there will be 27.5 million new cases of cancer each year. ... We ensure small-scale pilot or tolerability studies are carried out for new tumour types, experimental methods, or therapies.

19 Aug 2021: Page 2 of 9. What's the aim of this project? Our aim is to identify and validate new mechanisms for treating dementia, to identify novel, drug-like compounds that work ... Who or what will benefit from these outputs, and how? Data on new drug targets may

3 Mar 2021: from the AWERB Standing Committee to consider the 3Rs sections of some new project licence. ... where new or revisions are necessary to Standard Operating Procedures [SOPs] and implement University.

19 Aug 2021: Why is it important to undertake this work? It is important to undertake this work so that we can discover new drugs and better vaccines for treating and preventing many different ... New medicines, namely vaccines and drugs. Drugs that offer potential

13 Sep 2021: This will create new opportunities to test new therapies that can stop bad inflammation. ... This will also provide us the opportunity to build new collaborations locally and internationally.

19 Aug 2021: Similarly, it would not be possible to develop new treatments for brain disorders without testing them in animal models first. ... Thus, our recent work on environmental enrichment has actually shed new light on the rather anthropomorphic view of the

18 Jun 2021: D) Development and exploitation. It is possible that potential new treatments will be generated in this project. ... I attend numerous conferences, where new findings are presented, allowing improvements in our techniques and experiments.

13 Sep 2021: By disseminating our observations from early stages, for example via conferences, we create new collaborations with experts in research fields beyond our own. ... Methods and datasets generated in these types of analyses are made publicly available as

20 Aug 2021: Protocol 1: Superovulation. Superovulation is required for generating new transgenic strains, freezing lines, and importing new lines when rederivation is required. ... Protocol 3: Embryo recipient. Embryo recipients are required when thawing embryos

18 Jun 2021: our findings to help develop new strategies to identify, potentially prevent and treat blood cancers. ... Our new animal models, as well as tissues collected from the mice will be valuable to other scientists studying the development of blood cancers.