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Cambridge Fire and Rescue Service run training exercise at LMB - MRC…
https://www2.mrc-lmb.cam.ac.uk/cambridge-fire-rescue-service-run-training-exercise-lmb/6 Dec 2016: The LMB and Cambridge Fire and Rescue Service recently held a joint training exercise, involving six teams from across the region, a silver command unit -
Cryo-EM: The field that came in from the cold - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/cryo-em-the-field-that-came-in-from-the-cold/4 Jan 2016: Recent advances in electron cryo-microscopy are enabling researchers to solve protein structures at near-atomic resolutions, expanding the biological -
An evolutionarily conserved pathway controls proteasome homeostasis - …
https://www2.mrc-lmb.cam.ac.uk/evolutionarily-conserved-pathway-controls-proteasome-homeostasis/28 Jul 2016: Cell survival depends on adaptive signalling pathways to ensure that the supply of vital components matches the fluctuating needs of the cell. The -
Ultimate molecular machine plays key role in superbug fight - MRC…
https://www2.mrc-lmb.cam.ac.uk/ultimate-molecular-machine-plays-key-role-superbug-fight/7 Jun 2016: The ribosome is a complex biological machine that plays a central role in all living things and one that, according to Venki Ramakrishnan, could provide -
John O’Neill receives EMBO Young Investigator Programme Award - MRC…
https://www2.mrc-lmb.cam.ac.uk/john-oneill-receives-embo-young-investigator-programme-award/21 Oct 2016: LMB group leader, John O’Neill, has been elected into the 2016 EMBO Young Investigator Programme. This prestigious programme recognises some of Europe’s -
Molecular basis of APC/C regulation by the spindle assembly…
https://www2.mrc-lmb.cam.ac.uk/molecular-basis-apcc-regulation-spindle-assembly-checkpoint/11 Aug 2016: 11 August, 2016. During eukaryotic cell division (mitosis) the cell’s chromosomes are duplicated and then equally separated into two new daughter cells. -
Richard Henderson wins Royal Society’s prestigious Copley Medal - MRC …
https://www2.mrc-lmb.cam.ac.uk/richard-henderson-wins-royal-societys-prestigious-copley-medal/23 May 2016: The new structures provide important insights into the biological function of the assemblies and, by catalysing the subsequent development of new diagnostic or therapeutic tools, should help to improve the health -
Lauren Parker Jackson and Kristian Andersen named as Pew Scholars for …
https://www2.mrc-lmb.cam.ac.uk/lauren-parker-jackson-named-pew-scholar-biomedical-sciences/10 Jun 2016: The Pew Charitable Trusts have named 22 exceptional early-career scientists as Pew scholars in the biomedical sciences, including Lauren Parker Jackson -
Molecular mechanism triggering assembly of the Wnt signalosome…
https://www2.mrc-lmb.cam.ac.uk/molecular-mechanism-triggering-assembly-wnt-signalosome-uncovered/30 Sep 2016: The discovery has led to a new mechanistic model of Wnt signal transduction, in which Wnt-induced clustering of Dishevelled in clathrin-coated pits triggers DEP domain swapping and consequently signalosome -
2016 Francis Crick Lecture to be given by Adrian Bird - MRC…
https://www2.mrc-lmb.cam.ac.uk/2016-francis-crick-lecture-to-be-given-by-adrian-bird/9 Feb 2016: Adrian Bird will give the 2016 Francis Crick Lecture on Tuesday 16th February 2016 at 11.30am in the Max Perutz Lecture Theatre at the LMB. The lecture, -
HIV uses capsid pores to import nucleotides and evade innate immunity …
https://www2.mrc-lmb.cam.ac.uk/hiv-uses-capsid-pores-import-nucleotides-evade-innate-immunity/11 Aug 2016: This discovery presents the opportunity to re-evaluate existing treatments for HIV to improve their efficacy as well as a new drug target. ... Understanding how RTIs transit the pores opens new possibilities for improving their delivery. -
Vital nutrient has key role in keeping body clocks running on time -…
https://www2.mrc-lmb.cam.ac.uk/vital-nutrient-key-role-keeping-body-clocks-running-time/14 Apr 2016: Magnesium - a nutrient found in many foods - helps control how cells keep their own form of time to cope with the natural environmental cycle of day and -
If you can work anywhere, where do you want to work? - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/if-you-can-work-anywhere-where-do-you-want-to-work/29 Feb 2016: An article about modern work spaces featuring the LMB: "It is elegantly fit for purpose, and the purpose, says its director, Sir Hugh Pelham, is "doing -
Richard Henderson wins prize at Carlsberg’s ‘Science to Business’…
https://www2.mrc-lmb.cam.ac.uk/richard-henderson-wins-prize-carlsbergs-science-business-forum/1 Dec 2016: Richard Henderson, group leader at the LMB, has been awarded the Kaj Linderstrøm Lang Prize at Carlsberg’s ‘Science to Business’ Forum in recognition of -
Clotten Foundation Prize 2015 awarded to Professor Terry Rabbitts -…
https://www2.mrc-lmb.cam.ac.uk/clotten-foundation-prize-2015-awarded-professor-terry-rabbitts/15 Jul 2016: Professor Terry Rabbitts has been awarded the inaugural Clotten Foundation Prize 2015 for discoveries on human antibody genes leading to therapeutic -
LMB inspires the next generation of scientists with UTCC student…
https://www2.mrc-lmb.cam.ac.uk/lmb-inspires-next-generation-scientists-utcc-student-interactions/29 Jun 2016: The LMB has continued its collaboration with the University Technical College Cambridge (UTCC), with a series of visits, talks and a challenge project to -
Madeline Lancaster wins the 2015 3Rs Prize for 3D tissue models - MRC …
https://www2.mrc-lmb.cam.ac.uk/madeline-lancaster-wins-the-2015-3rs-prize-for-3d-tissue-models/29 Feb 2016: The paper also describes how the cerebral organoids can be used to model human microcephaly, a disorder recently in the news because of its association with the Zika virus outbreak. ... The development of the ‘cerebral organoids’ has significant -
How one scientist is growing miniature brains in her lab - MRC…
https://www2.mrc-lmb.cam.ac.uk/how-one-scientist-is-growing-miniature-brains-in-her-lab/11 Jan 2016: LMB neuroscientist Madeline Lancaster generates living models of brains from a few stem cells. In her lab, she takes small samples of stem cells and grows -
M. Madan Babu to deliver the Royal Society’s 2016 Francis Crick…
https://www2.mrc-lmb.cam.ac.uk/m-madan-babu-deliver-royal-societys-2016-francis-crick-lecture/24 Nov 2016: M. Madan Babu, a Group Leader in the LMB’s Structural Studies Division, will deliver the annual Francis Crick Lecture at the Royal Society on 7th December -
Daily magnesium fluxes regulate cellular timekeeping and energy…
https://www2.mrc-lmb.cam.ac.uk/daily-magnesium-fluxes-regulate-cellular-timekeeping-energy-balance/14 Apr 2016: These daily magnesium oscillations also affect the circadian rhythm of when ‘clock genes’ are turned on and off, and therefore seem to be a new component of the cell’s biological -
Drexel Prize in Translational Medicine awarded to Professor Jonathan…
https://www2.mrc-lmb.cam.ac.uk/drexel-prize-translational-medicine-awarded-professor-jonathan-karn/8 Sep 2016: Jonathan Karn, LMB 1976-2002, Postdoctoral staff and group leader, Cell Biology and PNAC Professor Jonathan Karn has been awarded the 2016 Drexel Prize in -
Development of effective immunity to infections is promoted by…
https://www2.mrc-lmb.cam.ac.uk/development-effective-immunity-infections-promoted-chromatin-component/25 May 2016: to new antigens. -
In vivo visualisation and quantification of the circadian clock…
https://www2.mrc-lmb.cam.ac.uk/vivo-visualisation-quantification-circadian-clock-protein-period2/1 Jul 2016: Circadian clocks are found across all higher species, controlling daily rhythms of behaviour and physiology. They are thought to “tick” by producing and -
Kelly Nguyen awarded Biochemical Society Early Career Research Award…
https://www2.mrc-lmb.cam.ac.uk/kelly-nguyen-awarded-biochemical-society-early-career-research-award-2017/31 Mar 2016: Thi Hoang Duong (Kelly) Nguyen from the LMB’s Structural Studies Division has won the prestigious Biochemical Society Early Career Research Award 2017 for -
The plastic fantastic brain: Why losing one sense rewires others -…
https://www2.mrc-lmb.cam.ac.uk/the-plastic-fantastic-brain-why-losing-one-sense-rewires-others/26 Jan 2016: A study finds worms that can't feel are better smellers - and the phenomenon is reversible. The collaborative study by Ithai Rabinowitch, Fred Hutchinson -
DNA discovery pioneer James Watson pays tribute to colleague Francis…
https://www2.mrc-lmb.cam.ac.uk/dna-discovery-pioneer-james-watson-pays-tribute-colleague-francis-crick/10 Jun 2016: This article is no longer available from the source website: Cambridge News 10 June 2016. -
Scientists are battling a drug-resistant pathogen which could prove…
https://www2.mrc-lmb.cam.ac.uk/scientists-battling-drug-resistant-pathogen-prove-fatal-patients-cystic-fibrosis/16 Nov 2016: infections, which can be fatal for cystic fibrosis patients, can be transferred from patient to patient, and how this new insight has impacted the design of the cystic fibrosis clinic in ... the new Papworth Hospital. -
Molecular principles of gene fusion mediated protein interaction…
https://www2.mrc-lmb.cam.ac.uk/molecular-principles-gene-fusion-mediated-protein-interaction-networks-cancer/19 Aug 2016: Cancer is an incredibly complex disease and data-intensive bioinformatics approaches can help interpret the molecular mechanism for why certain mutations cause disease, and possibly uncover the first steps of new -
Major breakthrough identifies cause and treatment of fatal autoimmune …
https://www2.mrc-lmb.cam.ac.uk/major-breakthrough-identifies-cause-treatment-fatal-autoimmune-disease/12 Aug 2016: The cause of a potentially fatal inherited autoimmune disease has been identified for the first time. The disease, now named OTULIN-related -
Mini-brains show great potential to replace animals in studying…
https://www2.mrc-lmb.cam.ac.uk/mini-brains-show-great-potential-replace-animals-studying-neurological-disease/4 Apr 2016: Madeline Lancaster has recently won the annual NC3Rs 3Rs Prize for her work on the creation of brain organoids that mimic the developing human cerebrum. -
"Sex, food and smell" Cambridge Science Festival talk…
https://www2.mrc-lmb.cam.ac.uk/sex-food-smell-cambridge-science-festival-talk-utc_cambridge-sunday-csf2016/16 Mar 2016: Join the LMB's Greg Jefferis for his talk: "Sex, food and smell" at the University Technical College Cambridge, Sunday 20 March: 12:45 - 1:45pm, to learn -
Body clocks & Jetlag Cambridge Science Festival talk…
https://www2.mrc-lmb.cam.ac.uk/body-clocks-jetlag-cambridge-science-festival-talk-utc_cambridge-friday-csf2016/14 Mar 2016: Join the LMB's John O'Neill for his talk: "Circadian rhythms: everything you always wanted to know about jetlag (but were too tired to ask)" at the -
Congratulations to Richard Henderson, winner of the 2016 Alexander…
https://www2.mrc-lmb.cam.ac.uk/congratulations-to-richard-henderson-winner-of-the-2016-alexander-hollaender-award-in-biophysics/22 Jan 2016: Richard Henderson will receive the National Academy of Sciences 2016 Alexander Hollaender Award in Biophysics for his outstanding contribution to the -
MD1-98 The LMB Screen
https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB21.pdf15 Jul 2016: Features of The LMB Crystallization Screen: • A brand new set of the most successful. -
Alessio Vagnoni awarded David Sainsbury Fellowship for work on…
https://www2.mrc-lmb.cam.ac.uk/alessio-vagnoni-awarded-david-sainsbury-fellowship-for-work-on-neuronal-ageing-in-a-non-mammalian-model/8 Mar 2016: Alessio Vagnoni, a post-doc in Simon Bullock’s group in the LMB’s Cell Biology Division has been awarded the NC3Rs David Sainsbury Fellowship 2015-2018. -
Understanding noise: the molecular determinants of random variation…
https://www2.mrc-lmb.cam.ac.uk/understanding-noise-the-molecular-determinants-of-random-variation-in-gene-expression-levels/2 Feb 2016: Cell-to-cell variability in gene expression level (noise) has emerged as one of the fundamental concepts in genetics. Non-genetic, cell-to-cell variation -
Ligand Sketcher Review (Open Source) Rob Nicholls…
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/nicholls-2016_Sept_Ligands.pdf26 Sep 2016: Do we even need something new? • Jligand. • Already part of CCP4 • Not really developed • 3D not 2D • Java. • -
Model Building and Refinement Practical Introduction In this…
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/mbar.docx27 Apr 2016: We will make use of the new NCS tools in the latest version of refmac5. ... The two new fields that appear can be left at their default values. -
REFMAC5 Tutorial
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/refmac_tutorial/index.html29 May 2016: For each case, you should create a new project in CCP4i2. -
BALBES - Automatic Molecular Replacement Pipeline BALBES is a ...
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/balbes.html4 Apr 2016: need help? please let us known). News. new features, release notes, and bug fixing reports). -
Keith_Ligand_Meeting_Dec2016
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/Keith_Ligand_Meeting_Dec2016.pdf9 Dec 2016: Dictionary entries. New coordinates (C2), based on above dictionary and REFMAC potentials. -
MRC-LMB robotic crystallisation: MRC plate
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/WWWrobots/robot-MRC-plate.html14 Feb 2016: The new designs incorporate a number of improvements over other plates that we identified while using our high-throughput facility as described here. -
LIGANDS Meetings ● Previously:– Developer → Users ● Now ...
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/emsley-ccp4-ligands-dec-2016.pdf9 Dec 2016: Re-refine. In the updated, Acedrg dictionary, the atom names are the same, one bond is different– Read old model and use new dictionary. – ... I'd rather work in coot and submit refinement jobs, and import and export new models and ligands. – -
Model Building and Refinement Practical Introduction In this…
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/ed-lowe-mb.docx27 Apr 2016: We will make use of the new NCS tools in the latest version of refmac5. ... The two new fields that appear can be left at their default values. -
Coot Updates Paul EmsleySept 2016 Coot 0.8.4 Released● Patterson ...
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/emsley-ccp4-ligand-meeting-sept-2016-v5.pdf28 Sep 2016: Lidia Improved letter placement. Old Coot New Coot RDKit. Coot Updates 0.8.7: Lidia. ... Given a ligand SMILES, how do I find out to which ligand (about which the PDB already knows) it is most similar?– Change the atom names of my new ligand to -
Activation of Xer-recombination at dif: structural basis of the…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/srep33357.pdf30 Sep 2016: New Biol 3, 799–811 (1991). 7. Carnoy, C. & Roten, C. ... J. & Donachie, W. D. A new Escherichia coli cell division gene, ftsK. -
Collaborative protein filaments
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/ghosal_embo_2015.pdf4 Jan 2016: A simple filament nomenclature. Since ever more filament systems with new architectures are being. ... CM (2014) Subpolar addition of new cell wall is directed by DivIVA in. -
14821680963433 1..18
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/e21600-download.pdf19 Dec 2016: panel). In this new position, the loop interacts extensively with subunits of the opposite strand (Fig-. ... to add a stop codon after residue E167 using Q5 site directed mutagenesis (New England Biolabs,. -
70 88..91
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/97_Voorhees_RM_Science_2016.pdf5 Jan 2016: F.Z. is supported by the National Institutesof Health through NIMH (5DP1-MH100706 and 1R01MH110049)and NIDDK (5R01DK097768-03), a Waterman Award from theNational Science Foundation, the Keck, New York Stem ... Metcalfe. F.Z. is a New York Stem Cell -
Ribosome-associated protein quality control
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/98_Brandman_O_NSMB_2016.pdf18 Feb 2016: 5a,b) has led to new insights that might hold the key to understanding this stress response.
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