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Eureka Moments: making proteins, making a difference - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/eureka-moments-making-proteins-making-a-difference/21 Apr 2011: “In the second of the Biochemical Society's video interviews with our Honorary Members, Michael Neuberger and Brian Hartley talk to Sir Greg Winter -
LMB at the Cambridge Science Festival: 19th March. - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/lmb-at-the-cambridge-science-festival-19th-march/16 Mar 2011: On Saturday 19th March 2011, as part of the annual Cambridge Science Festival, LMB scientists are involved in events across Cambridge aimed at promoting -
A small molecule to correct protein folding defects. - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/a-small-molecule-to-correct-protein-folding-defects/10 Mar 2011: to design new drugs that could benefit a broad range of diseases. -
First X-ray crystal structure of dynein motor domain - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/first-x-ray-crystal-structure-of-dynein-motor-domain/4 Mar 2011: The research was carried out over the last seven years by Andrew Carter, a new group leader in LMB’s Structural Studies Division, and Carol Cho, a graduate student who worked ... C&EN news article:Primary Sidebar. Search. Search this website. 2024 MRC -
Alcohol damages DNA of unborn children beyond repair - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/alcohol-damages-dna-of-unborn-children-beyond-repair/7 Jul 2011: “LMB scientists have identified the precise molecular mechanism leading to the breakdown of the body's natural defences that protect DNA against -
Jan Löwe to receive Wellcome Trust Senior Investigator Award. - MRC…
https://www2.mrc-lmb.cam.ac.uk/jan-lowe-to-receive-wellcome-trust-senior-investigator-award/7 Jun 2011: The Wellcome Trust has appointed 27 Investigators – 7 New Investigators and 20 Senior Investigators – based at institutions across the UK, from London to Liverpool, Edinburgh to Manchester, as well as to ... The overall aim of obtaining a chemical -
Heptares Therapeutics helps push GPCR drug discovery forward - MRC…
https://www2.mrc-lmb.cam.ac.uk/heptares-therapeutics-helps-push-gpcr-drug-discovery-forward/14 Mar 2011: G-protein-coupled receptors are hot drug targets, and plenty of companies want to know what they look like to get an edge on making new drugs. -
Winners of Imagining the Brain Competition Receive Prizes. - MRC…
https://www2.mrc-lmb.cam.ac.uk/winners-of-imagining-the-brain-competition-receive-prizes/28 Sep 2011: We intend to buy new equipment for the art department with this money. ... It affords young artists the chance to experience working to a brief, applying their arts practice to a new and different concept and, if they are selected, they can experience -
2011 Max Perutz Science Writing Award shortlist announced - MRC…
https://www2.mrc-lmb.cam.ac.uk/2011-max-perutz-science-writing-award-shortlist-announced/26 Jul 2011: “Samuel Bjork from the MRC LMB shortlisted for this year's Max Perutz Science Writing award.” More… -
Andrew McKenzie elected as Academy of Medical Sciences Fellow - MRC…
https://www2.mrc-lmb.cam.ac.uk/andrew-mckenzie-elected-as-academy-of-medical-sciences-fellow/18 May 2011: This work has also led to the identification of a new immune cell, called the nuocyte, that plays a key role in these responses. -
2011 César Milstein Lecture to be given by Tom Rapoport. - MRC…
https://www2.mrc-lmb.cam.ac.uk/inaugural-milstein-lecture-to-be-given-by-tom-rapoport/4 Apr 2011: Professor Tom Rapoport from the Department of Cell Biology, Harvard Medical School will give the inaugural Milstein Lecture on Thursday April 7th 2011 at -
Nobelist Steitz: Smart lunches can lead to great science - MRC…
https://www2.mrc-lmb.cam.ac.uk/nobelist-steitz-smart-lunches-can-lead-to-great-science/20 Jul 2011: “At the Lindau Nobel Laureate Meeting, 2009 chemistry laureate Thomas Steitz recalled the Laboratory of Molecular Biology at Cambridge in the 1960s, -
Jason Embleton takes to water in boat made of bottle tops - MRC…
https://www2.mrc-lmb.cam.ac.uk/jason-embleton-takes-to-water-in-boat-made-of-bottle-tops/16 Jun 2011: no longer available from the source website: Cambridge News 13 June 2011. -
In vivo role for Fanconi Anaemia DNA repair pathway identified - MRC…
https://www2.mrc-lmb.cam.ac.uk/in-vivo-role-for-fanconi-anaemia-dna-repair-pathway-identified/7 Jul 2011: In a new study published in the journal Nature today, they also discovered a two-tier defence system in our cells that limits the threat of permanent genetic damage. ... This new knowledge transforms our view of precisely how excess alcohol causes damage -
Understanding how hormones activate G protein-coupled receptors. -…
https://www2.mrc-lmb.cam.ac.uk/understanding-how-hormones-activate-g-protein-coupled-receptors/25 Jan 2011: News & Views). – now at the Paul Scherrer Institut. Primary Sidebar. -
Inaugural Francis Crick Lecture to be given by David Anderson. - MRC…
https://www2.mrc-lmb.cam.ac.uk/inaugural-francis-crick-lecture-to-be-given-by-david-anderson/5 Sep 2011: The application of genetically based tools for marking, mapping and manipulating specific populations of neurons, together with machine vision-based approaches for automated analysis of behavior, have opened up new opportunities -
Fine display of brain power from students in science competition -…
https://www2.mrc-lmb.cam.ac.uk/fine-display-of-brain-power-from-students-in-science-competition/30 Sep 2011: is no longer available from the source website: Cambridge News 30 September 2011. -
Greg Winter presented with Distinguished Technopreneur Speaker Award…
https://www2.mrc-lmb.cam.ac.uk/greg-winter-presented-with-distinguished-technopreneur-speaker-award/19 Jan 2011: “The Distinguished Technopreneur Speaker (DTS) Forum, organised by Exploit Technologies, serves as a relevant platform for entrepreneurs, industry -
Christian Münch Receives British Neuroscience Association…
https://www2.mrc-lmb.cam.ac.uk/christian-munch-receives-british-neuroscience-association-postgraduate-award/15 Dec 2011: Christian Münch, a postgraduate student working in Anne Bertolotti’s group in the LMB’s Division of Neurobiology has been awarded the 2011 British -
Cambridge's largest ever M&A deals: the top 10 | Cambridge…
https://www2.mrc-lmb.cam.ac.uk/archive/articles/M_&_A_deal_Cabume.pdf22 Dec 2011: Handy Elephantgoes public onnew email appSoftware. HOME NEWS FEATURES VIDEO & AUDIO DIRECTORY CONTACT. -
Jillian Barlow wins 2nd prize in MedImmune Global Abstract…
https://www2.mrc-lmb.cam.ac.uk/jillian-barlow-wins-2nd-prize-in-medimmune-global-abstract-competition/15 Nov 2011: “Jillian Barlow from LMB's PNAC Division is recognized for excellence in respiratory, inflammation and autoimmunity research at MedImmune's 6th -
Hijacking protein quality control to regulate cellular communication. …
https://www2.mrc-lmb.cam.ac.uk/hijacking-protein-quality-control-to-regulate-cellular-communication/1 Apr 2011: When the first multicellular organisms evolved, their cells needed to communicate with each other to control their growth and development. Matthew -
John Sutherland awarded the Royal Society of Chemistry Tilden Prize…
https://www2.mrc-lmb.cam.ac.uk/john-sutherland-awarded-the-royal-society-of-chemistry-tilden-prize-2011/16 May 2011: John Sutherland has been awarded the Royal Society of Chemistry Tilden Prize for 2011. The Tilden Prize is awarded annually to recognise achievements in -
Philip Heard awarded Cambridge Regional Colleges Best Overall Learner …
https://www2.mrc-lmb.cam.ac.uk/philip-heard-awarded-cambridge-regional-colleges-best-overall-learner-for-2011/17 Jun 2011: Philip Heard from the LMB’s Mechanical Workshop has been awarded Cambridge Regional College’s annual award for Best Overall Learner. It is awarded to the -
Nobel Laureate, Sir Aaron Klug, donates his archives to Churchill…
https://www2.mrc-lmb.cam.ac.uk/nobel-laureate-sir-aaron-klug-donates-his-archives-to-churchill-archives-centre/26 Apr 2011: One of the pioneers of structural molecular biology, Sir Aaron Klug, former Director of the LMB, has given his extensive archive to the Churchill Archives -
Mariann Bienz talks about signalling pathways as a target for cancer…
https://www2.mrc-lmb.cam.ac.uk/mariann-bienz-talks-about-signalling-pathways-as-a-target-for-cancer-therapies/14 Feb 2011: “A number of signalling pathways discovered in Drosophila flies and other model organisms have subsequently turned out to be important in cancer and -
LMB spin-out companies, CAT and Domantis, in top 10 of Cambridge…
https://www2.mrc-lmb.cam.ac.uk/lmb-spin-out-companies-cat-and-domantis-in-top-10-of-cambridge-mergers-and-acquisitions/26 Aug 2011: “Cambridge Business Media pick their top 10 mergers and acquisitions of Cambridge cluster companies in terms of deal value. Included are LMB -
Changing the locks: HIV discovery could allow scientists to block…
https://www2.mrc-lmb.cam.ac.uk/changing-the-locks-hiv-discovery-could-allow-scientists-to-block-viruss-entry-into-cell-nucleus/9 Dec 2011: The finding, published today in the open access journal PLoS Pathogens, provides a potential new target for anti-AIDS drugs that could be more effective against drug-resistant strains of the -
Dinolite instructions
https://www2.mrc-lmb.cam.ac.uk/microscopes4schools/downloads/dinolite_instructions.pdf6 Jun 2011: This information is also automatically saved. 3. To take a new image, place your mouse over anything other than an existing thumbnail. -
Endocytic Interactome: How Interactomes can help us design…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/Interactomes/index.html26 Sep 2011: What is endophilin and how does it work. Research on the mechanism of endophilin in rapid vesicle endocytosis. Research on proteins involved in clathrin-coated vesicle formation. Research on membrane bending. Research on protein-lipid interactions. -
Scientists in Cambridgeshire are to lead a £3.6m project looking at…
https://www2.mrc-lmb.cam.ac.uk/scientists-in-cambridgeshire-are-to-lead-a-3-6m-project-looking-at-the-effects-of-ageing-on-immunity-systems/9 Dec 2011: “The Babraham Institute has received the funds from the Biotechnology and Biological Sciences Research Council. The project will study how changes -
Clathrin-mediated endocytosis: Coated vesicle assembly. There are 3…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/Endocytosis/CCVAssembly.html26 Sep 2011: Steps in CCV assembly and links to structures and information around clathrin-coated vesicle formation and other forms of vesicle budding -
Clathrin-mediated endocytosis: Adaptor appendage domains.…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/Adaptors/Appendages.html26 Sep 2011: Appendage/ear domains recruit accessory proteins (see previous page) and are structurally and functionally conserved not merely amongst heterotetrameric AP complexes but also in subunits of the COPI coat complex and in GGAs (Golgi-localized, -
AP180, CALM and clathrin-mediated endocytosis. AP180 recruits…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/AP180/AP180.html26 Sep 2011: AP180/CALM Home Page. AP180 is a brain enriched component of clathrin-coated vesicle that is essential for synaptic vesicle recycling. CALM is a ubiquitous homologue. How it works:. Click pictures for links. We have shown that AP180 recruits -
Clathrin and its interactions with AP180. AP180 is a brain enriched…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/AP180/Clathrin.html26 Sep 2011: AP180 is a brain enriched protein essential for the recycling of synaptic vesicles after exocytosis and CALM is a ubiquitous homologue. AP180 co-purifies with clathrin-coated vesicle (see purification) and we have shown that it functions to tether -
Endocytosis and Membrane Trafficking Pathways: McMahon Lab research…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/research/research.html26 Sep 2011: These pages contains resources that you are free to download and use as long as you acknowledge the source. There are pages for many endocytic and trafficking proteins. -
AP2 Adaptors Adaptor Home Page Appendage Domains CCV Assembly ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/epsin.html26 Sep 2011: see also News and Views and highlights in Nature Cell Biology, Nature reviews in molecular cell biology, and a mini review in Cell (Cell October 18, 2002: 111 -
ENTH domain: A conserved N-terminal domain which in epsin1, 2 and 3…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/Structure.html26 Sep 2011: Note the hydrophobic residues on the outer surface of this new helix (Helix 0). ... see also News and Views and highlights in Nature Cell Biology, Nature reviews in molecular cell biology, and a mini review in Cell (Cell October 18, 2002: 111 (2):143-146) -
Earlier McMahon Publications
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/oldpaper.html26 Sep 2011: Nature 364, 346-349. (see also News and Views). Link, E., McMahon, H., Fischer von Mollard, G., Yamasaki, S., Niemann, H., Südhof, T.C. ... Nature 365, 163-166. (see also News and Views). McMahon, H.T. and Nicholls, D.G. -
Date: 4-5th April 2011 Venue: School of Biosciences, University ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/conferences/BirminghamProgram.pdf4 Mar 2011: Trains run from New Street Station to University Station roughly every 10 minutes. ... £60-80 Britannia Hotel Birmingham New Street, B2 4RX Price range: £65-£70. -
Molecular basis for membrane remodelling and organization
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/F-BAR_proteins/JMConference/barbara_winsor.html13 Dec 2011: Peter (Peter Greer, Queen’s University, Ontario, Canada). These are really sad news. ... Violeta Chitu (Albert Einstein College of Medicine, New York). I'm shocked to hear this news, please accept my condolences. -
Science Magazine
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/sciencetubzactinglikeactin.pdf5 Jan 2011: Because the studied compound, HgBa. 2CuO. 4δ,. is thought to be representative of the cuprates, and the new magnetic excitation appears at the same T. ... MedicineIntegrating Medicine. and Science. The new journal from the publisherof Science stands at -
The life of proteins: the good, the mostly good and the ugly
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/68_Morimoto_RI_NSMB_2011.pdf7 Jan 2011: Several new concepts and methods are bringing nascent-chain biology to the forefront of the field. ... Nascency and nascent-chain biologyReplenishment and renewal of the ‘protein community’ of cellular proteins requires new proteins to be synthesized. -
Protein-driven membrane stresses in fusion and fission
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/KozlovCurvature2010.pdf21 Feb 2011: This zippering explains how generation of aSNARE complex brings the membranes together, but doesnot explain the mechanism of membrane fusion per se [53].New results show that SNARE assembly tends to -
Biochem. J. (2011) 440, 185–193 (Printed in Great Britain) ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/ChernomordikBJ2011.pdf15 Nov 2011: Better understanding of the mechanism and cellmachinery responsible for driving fusion pore expansion in cell-to-cell fusion will bring about new ways of controlling fusion indevelopment and in pathological conditions. -
pii:B978-0-12-372568-4.00001-X
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/MartensCTMchapter6.pdf3 May 2011: Neurotransmitters arereleased into the synaptic cleft and bind to postsynaptic receptors to activate/modulate its activity.Vesicle components and membrane are recycled by endocytosis either directly to form new synapticvesicles or -
Abstract_Book_HMM_v2
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/conferences/JM_Abstract_Book.pdf15 Sep 2011: James E. ROTHMAN (New Haven, U.S.A.) The mechanism of control of neurotransmitter release Le mécanisme de contrôle de la libération des neurotransmetteurs. - ... challenged. My presntation will highlight and disccuss the new findings regrading the -
Tail-anchored membrane protein insertion into the endoplasmic…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/77_Hegde_RS_NRMCB_2011.pdf16 Nov 2011: Discovery of a new insertion pathwayAs the SRPdependent pathway was being elucidated, it became clear that at least some membrane proteins might not be able to use this route for insertion. ... After release from Get1, what prevents Get3–ATP from -
Volume 22 May 15, 2011 1625 Cytosolic aggregates perturb ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/69_Chakrabarti_O_MBC_2011.pdf11 Nov 2011: types, but the gain of a new functional property of the protein and/or aggregate. ... visualization of intracellular PrP, and permitted us to assay the subse-quent rate of repopulation of PrP by new synthesis. -
Molecular Biology of the CellVol. 21, 3054 –3069, September ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/RVS161_MBC2010.pdf21 Feb 2011: Molecular Biology of the CellVol. 21, 3054 –3069, September 1, 2010. Dissecting BAR Domain Function in the YeastAmphiphysins Rvs161 and Rvs167 during EndocytosisJi-Young Youn,‡ Helena Friesen,†‡ Takuma Kishimoto, William M. Henne,Christoph
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