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Clathrin-mediated endocytosis: Adaptor appendage domains.…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/Adaptors/Appendages.html26 Sep 2011: Appendage/ear domains recruit accessory proteins (see previous page) and are structurally and functionally conserved not merely amongst heterotetrameric AP complexes but also in subunits of the COPI coat complex and in GGAs (Golgi-localized, -
AP180, CALM and clathrin-mediated endocytosis. AP180 recruits…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/AP180/AP180.html26 Sep 2011: AP180/CALM Home Page. AP180 is a brain enriched component of clathrin-coated vesicle that is essential for synaptic vesicle recycling. CALM is a ubiquitous homologue. How it works:. Click pictures for links. We have shown that AP180 recruits -
Clathrin and its interactions with AP180. AP180 is a brain enriched…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/AP180/Clathrin.html26 Sep 2011: AP180 is a brain enriched protein essential for the recycling of synaptic vesicles after exocytosis and CALM is a ubiquitous homologue. AP180 co-purifies with clathrin-coated vesicle (see purification) and we have shown that it functions to tether -
Endocytosis and Membrane Trafficking Pathways: McMahon Lab research…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/research/research.html26 Sep 2011: These pages contains resources that you are free to download and use as long as you acknowledge the source. There are pages for many endocytic and trafficking proteins. -
AP2 Adaptors Adaptor Home Page Appendage Domains CCV Assembly ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/epsin.html26 Sep 2011: see also News and Views and highlights in Nature Cell Biology, Nature reviews in molecular cell biology, and a mini review in Cell (Cell October 18, 2002: 111 -
ENTH domain: A conserved N-terminal domain which in epsin1, 2 and 3…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/Structure.html26 Sep 2011: Note the hydrophobic residues on the outer surface of this new helix (Helix 0). ... see also News and Views and highlights in Nature Cell Biology, Nature reviews in molecular cell biology, and a mini review in Cell (Cell October 18, 2002: 111 (2):143-146) -
Earlier McMahon Publications
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/oldpaper.html26 Sep 2011: Nature 364, 346-349. (see also News and Views). Link, E., McMahon, H., Fischer von Mollard, G., Yamasaki, S., Niemann, H., Südhof, T.C. ... Nature 365, 163-166. (see also News and Views). McMahon, H.T. and Nicholls, D.G. -
Date: 4-5th April 2011 Venue: School of Biosciences, University ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/conferences/BirminghamProgram.pdf4 Mar 2011: Trains run from New Street Station to University Station roughly every 10 minutes. ... £60-80 Britannia Hotel Birmingham New Street, B2 4RX Price range: £65-£70. -
Molecular basis for membrane remodelling and organization
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/F-BAR_proteins/JMConference/barbara_winsor.html13 Dec 2011: Peter (Peter Greer, Queen’s University, Ontario, Canada). These are really sad news. ... Violeta Chitu (Albert Einstein College of Medicine, New York). I'm shocked to hear this news, please accept my condolences. -
Science Magazine
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/sciencetubzactinglikeactin.pdf5 Jan 2011: Because the studied compound, HgBa. 2CuO. 4δ,. is thought to be representative of the cuprates, and the new magnetic excitation appears at the same T. ... MedicineIntegrating Medicine. and Science. The new journal from the publisherof Science stands at -
The life of proteins: the good, the mostly good and the ugly
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/68_Morimoto_RI_NSMB_2011.pdf7 Jan 2011: Several new concepts and methods are bringing nascent-chain biology to the forefront of the field. ... Nascency and nascent-chain biologyReplenishment and renewal of the ‘protein community’ of cellular proteins requires new proteins to be synthesized. -
Protein-driven membrane stresses in fusion and fission
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/KozlovCurvature2010.pdf21 Feb 2011: This zippering explains how generation of aSNARE complex brings the membranes together, but doesnot explain the mechanism of membrane fusion per se [53].New results show that SNARE assembly tends to -
Biochem. J. (2011) 440, 185–193 (Printed in Great Britain) ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/ChernomordikBJ2011.pdf15 Nov 2011: Better understanding of the mechanism and cellmachinery responsible for driving fusion pore expansion in cell-to-cell fusion will bring about new ways of controlling fusion indevelopment and in pathological conditions. -
pii:B978-0-12-372568-4.00001-X
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/MartensCTMchapter6.pdf3 May 2011: Neurotransmitters arereleased into the synaptic cleft and bind to postsynaptic receptors to activate/modulate its activity.Vesicle components and membrane are recycled by endocytosis either directly to form new synapticvesicles or -
Abstract_Book_HMM_v2
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/conferences/JM_Abstract_Book.pdf15 Sep 2011: James E. ROTHMAN (New Haven, U.S.A.) The mechanism of control of neurotransmitter release Le mécanisme de contrôle de la libération des neurotransmetteurs. - ... challenged. My presntation will highlight and disccuss the new findings regrading the -
Tail-anchored membrane protein insertion into the endoplasmic…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/77_Hegde_RS_NRMCB_2011.pdf16 Nov 2011: Discovery of a new insertion pathwayAs the SRPdependent pathway was being elucidated, it became clear that at least some membrane proteins might not be able to use this route for insertion. ... After release from Get1, what prevents Get3–ATP from -
Volume 22 May 15, 2011 1625 Cytosolic aggregates perturb ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/69_Chakrabarti_O_MBC_2011.pdf11 Nov 2011: types, but the gain of a new functional property of the protein and/or aggregate. ... visualization of intracellular PrP, and permitted us to assay the subse-quent rate of repopulation of PrP by new synthesis. -
Molecular Biology of the CellVol. 21, 3054 –3069, September ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/RVS161_MBC2010.pdf21 Feb 2011: Molecular Biology of the CellVol. 21, 3054 –3069, September 1, 2010. Dissecting BAR Domain Function in the YeastAmphiphysins Rvs161 and Rvs167 during EndocytosisJi-Young Youn,‡ Helena Friesen,†‡ Takuma Kishimoto, William M. Henne,Christoph -
Molecular mechanism and physiological functions of clathrin-mediated…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/McMahon%20NRMB%202011.pdf19 Jul 2011: Perhaps what we now require is not new pathway inhibitors but precise inhibitors of specific receptor recruitment into coated pits, so that we can probe endocytosis with minimal side effects on -
Molecular Biology of the CellVol. 21, 4325– 4337, December ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/67_Emerman_AE_MBC_2010.pdf11 Nov 2011: Molecular Biology of the CellVol. 21, 4325– 4337, December 15, 2010. Compartment-Restricted Biotinylation Reveals NovelFeatures of Prion Protein Metabolism in VivoAmy B. Emerman, Zai-Rong Zhang, Oishee Chakrabarti,†and Ramanujan S. Hegde. Cell
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