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Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/CircGen_2019.pdf1 Dec 2019: Circ Genom Precis Med. 2019;12:e002507. DOI: 10.1161/CIRCGEN.119.002507 September 2019 397. BACKGROUND: Pediatric cardiomyopathies are a clinically and genetically heterogeneous group of heart muscle disorders associated with high morbidity and -
doi:10.1016/j.cell.2006.01.047
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16615893.pdf18 Apr 2006: levels, is that overexpression of exogenous Tsg101 se-. questers endogenous Tsg101 binding partners (Vps28. ... Tal, a Tsg101-spe-. cific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus. -
Membrane fusion is the process whereby two separate lipid ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MartensMcMahon2008.pdf16 May 2008: derived from a retrovirus. Syncytins function in cell–cell fusion during trophoblast formation. Immunoglobulin (Ig)-like Results that match 1 of 2 words
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https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/22221
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/22221{"id":22221,"date":"2022-01-20T12:51:11","date_gmt":"2022-01-20T12:51:11","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=22221"},"modified":"2022-01-20T12:51:11","modified_gmt":"2022-01-20T12:51:11","slug":"cryptochrome-proteins-are-integral-t -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/4350
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/4350{"id":4350,"date":"2012-03-30T12:32:49","date_gmt":"2012-03-30T12:32:49","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?p=4350"},"modified":"2019-12-20T11:54:12","modified_gmt":"2019-12-20T11:54:12","slug":"inaugural-john-kendrew-lectur -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/22945
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/22945{"id":22945,"date":"2022-05-05T09:18:08","date_gmt":"2022-05-05T08:18:08","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=22945"},"modified":"2022-05-05T09:18:08","modified_gmt":"2022-05-05T08:18:08","slug":"2022-john-kendrew-lecture-to-be-give -
Effects of Epsin R overexpression
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsinR/Endogenous_epsinr.html25 Jun 2007: Endogenous epsinR with Myc-epsin1 and Myc-epsinR. Endogenous EpsinR. ... Endogenous EpsinR. Overexpressed. Myc-EpsinR. Endogenous epsinR expression. -
Effects of Epsin R overexpression
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsinR/epsinrWT.html25 Jun 2007: Myc-EpsinR WT with endogenous AP1 and transferrin uptake in COS cells. ... Endogenous epsinR and overexpressed epsinR do not overlap with overexpressed epsin1 (see link), but there is considerable overlap with TGN markers (see below). -
LMB Fellows - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/group-leaders/lmb-fellows/23 Apr 2024: His application of forward-genetic screens discovered the Human Silencing Hub ‘HUSH’, the critical transcriptional epigenetic repressor complex for silencing both newly integrated retroviruses and mobile endogenous retrotransposons. -
Epsin 1 colocalization with endocytic markers
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/IF/E1coloc.html25 Jun 2007: Colocalisation of the wild type epsin (green) with endogenous clathrin (X22), Eps15 (Ra15), dynamin (McNiven antibody) and AP1 (100.3). -
Kate McDole - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/group-leaders/h-to-m/kate-mcdole/21 Jul 2023: Generation and live imaging of an endogenous Cdx2 reporter mouse line.. -
How eating feeds into the body clock - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/how-eating-feeds-into-the-body-clock/25 Apr 2019: These are endogenous daily rhythms that occur in every cell of the body; affecting a wide range of physiological processes, from when we sleep, to hormone levels, to how quickly we -
EpsinR (epsin4) immunofluorescence: an AP1/clathrin interacting…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsinR/index.html26 Sep 2011: Myc-EpsinR with endogenous TGN46 and AP1 in COS cells. In the image to the left there are 2 cells transfected with Myc-epsinR and 3 cells not transfected. ... In the left cells endogenous AP1 is finely punctate and co-localises with the more tubular -
Effects of Epsin R overexpression
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsinR/epsinrL10E.html25 Jun 2007: Myc-EpsinR L10E with endogenous AP1 and internalised transferrin in COS cells. -
Discovering the origins of biological timekeeping - MRC Laboratory of …
https://www2.mrc-lmb.cam.ac.uk/discovering-the-origins-of-biological-timekeeping/20 Apr 2015: Published on. 20 April, 2015. The existence of an endogenous daily clock in humans is well known: it is what drives the 24-hour sleep/wake rhythm to match the daily -
HIV uses capsid pores to import nucleotides and evade innate immunity …
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fhiv-uses-capsid-pores-import-nucleotides-evade-innate-immunity%2F&format=xmlmrc-lmb.cam.ac.uk/wordpress/wp-content/uploads/Leo-James-HIV-Nature-cover-28-July-16.jpg 700 700 HIV is a retrovirus, meaning it has to copy its RNA -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/9259
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/9259HIV is a retrovirus, meaning it has to copy its RNA genome into DNA in order to infect cells. -
Decade-long collaboration results in the first structure of the…
https://www2.mrc-lmb.cam.ac.uk/decade-long-collaboration-results-in-the-first-structure-of-the-fanconi-anaemia-core-complex/31 Oct 2019: to exogenous chemicals, such as chemotherapeutic drugs and alcohol, or endogenous by-products of normal cellular metabolism. -
doi:10.1016/j.cub.2004.09.077
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Snx1PeteCullen2004/Snx1PeteCullen2004.pdf23 Nov 2004: Endogenous SNX1 was enriched on tubularmembranes in close vicinity to endosomal vacuoles (Fig-ure 3). ... These data establish a role for endogenous SNX1in the retrieval of the CI-MPR from early endosomes tothe TGN. -
The ER membrane protein complex is a transmembrane domain insertase
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Science_2017c.pdf27 Jan 2018: This system contains endogenous mRNAs (primarily encoding the 14 kD globins and a prominent 70 kD protein) that contribute to background, but has the advantage of retaining native cytosolic conditions, most ... aureus is used to digest endogenous mRNA. -
Articleshttps://doi.org/10.1038/s41594-019-0196-z A folded…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Burmann%20NSMB%202019%20SI.pdf26 Feb 2019: c, Growth of strains containing point mutations at the elbow in the endogenous mukB gene. -
A positively charged channel within the Smc1/Smc3 hinge required for…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/embosmcjingekurze2010.pdf1 Dec 2010: together with endogenous Smc3. Western blotting revealed. that immunoprecipitates of Smc3-HA3 or Smc3AAA-HA3. ... As expected, similar amounts of Smc1-myc9 and endogenous. Smc1 associate with Smc3-HA3. -
1256917combinedsupplement
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Gligoris-SM.pdf14 Nov 2014: Scc1’s endogenous M1 has been deleted, an N-terminal myc9 epitope was fused in frame and endogenous M30 was changed to I30. ... Endogenous Scc1M102, Smc3M139 and M186 generate a 30 kDa Scc1 and a 5 kDa Smc3 fragment. -
Filament structure and subcellular organization of the bacterial…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Liu_PNAS_crescentin_2024.pdf28 Apr 2024: This yielded protein levels of CreS similar to endogenous levels in wt strain CB15N (SI Appendix, Fig. ... Subcellular Organization of CreS Filaments. The ultrastructure of endogenous CreS assemblies at normal levels in C. -
Bb9e55.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Vallis_McMahon1999.pdf21 Mar 2003: Mol Biol Cell 1998, 9:195a. 22. Tuma PL, Stachniak MC, Collins CA: Activation of dynamin GTPaseby acidic phospholipids and endogenous rat brain vesicles. ... such adynaminPH construct into COS cells will be even betterat sequestering endogenous dynamin -
Cryptochrome proteins are integral to maintain time within the…
https://www2.mrc-lmb.cam.ac.uk/cryptochrome-proteins-are-integral-to-maintain-time-within-the-brains-master-clock/20 Jan 2022: Published on. 20 January, 2022. A schematic showing the effect of CRY1 on the relationships between localisation and intracellular mobility of endogenous fluorescently tagged PER2 as well as circadian rhythmicity of ... Real-time imaging of endogenous -
doi:10.1016/j.devcel.2008.06.015
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/54_Rane_NS_DevCell_2008.pdf18 Sep 2008: Ifn-PrP. Note the lack of changes to endogenous PrP in cells expressing. ... Thus, in both cases, Ifn-PrP is not being overexpressed relative. to endogenous PrP. -
© 2005 Nature Publishing Group Endophilin and CtBP/BARS are ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/GallopEndopohilinNature2005.pdf4 Jan 2006: A JC201 strain ofEscherichia coli lacking endogenous LPAAT activity grows at 30 8Cbut not at 42 8C (ref. ... coli that has no endogenous LPAATactivity (JC201 strain) cannot growat 42 8C (sector 1). -
pq240013132p
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/16_Wilhelm_JE_PNAS_2000.pdf10 Nov 2000: 1B), despitethe fact that endogenous Vg1 was expressed only in the late-stageoocytes (Fig. ... 1C). This result raisesthe possibility that the endogenous, localized Vg1 message is inan environment that is free from repression. -
TBS may template.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/EMreview.pdf3 May 2002: This might be caused bycompetition for clathrin binding between the injectedpeptide and the endogenous protein, therebypreventing endogenous AP180 and AP2 frompromoting clathrin assembly at the plasmamembrane. -
Cooperative Recruitment of Dynamin and BIN/Amphiphysin/Rvs (BAR)…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/JBC_Meinecke2013.pdf19 Mar 2013: Amph12 RNAi) depletion on the recruitment of endogenous dynamin 2 (dynaminen, green and white arrows) and clathrin light chain A (clathrinen, red). ... Bar, 10µm (B) Effect of SNX9, amphiphysin and endophilin overexpression on endogenous dynamin 2 -
Membrane curvature sensing and induction: The function of BAR domains …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/BARdomains/BARsupp.pdf20 Nov 2003: S6. Colocalization of wild type, mutant, and endogenous arfaptin with TGN46 Table S1. -
doi:10.1016/j.molcel.2004.08.030
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Haering%20Mol%20Cell%202004.pdf20 Sep 2004: Cells separatedsister chromatids with identical kinetics to those thatof the GAL1-10 promoter in cells with an endogenous. ... Nevertheless, noncleavableScc1-HA3 from the endogenous SCC1 promoter. The. sole copy of Cdc20 in all three strains was -
The GTPase-Activating Protein GRAF1 Regulates the CLIC/GEEC Endocytic …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Lundmark_McMahon_GRAF2008.pdf28 Nov 2008: G) Epifluorescence micrographs of a HeLa cell incubated with CTxB for 5 min before fixation and staining for endogenous GRAF1. ... B, Confocal micrograph of an NIH 3T3 cell stained for endogenous GRAF1 distribution. -
Transmembrane Domain Modulates Sorting of MembraneProteins in…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/29_Karsten_V_JBC_2004.pdf2 Jun 2004: 1B).BAPGRA4 was localized to dense granules as evidenced bycolocalization with the endogenous dense granule proteinGRA3 (32). ... Both endogenous GRA4 andBAPGRA4 were efficiently translocated across the ER mem-brane (Fig. -
TBS may template.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/EM/mcmahon.pdf3 May 2002: This might be caused bycompetition for clathrin binding between the injectedpeptide and the endogenous protein, therebypreventing endogenous AP180 and AP2 frompromoting clathrin assembly at the plasmamembrane. -
53091 361..366
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/McMahonE.pdf3 Dec 2004: endogenous AP2 (middle, AP6 antibody) and transferrin uptake (right). A strong. -
Features critical for membrane binding revealed by DivIVA crystal…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/emboj201099a.pdf20 May 2010: tionally complements an endogenous divIVA replacement. This was also seen when sporulation of these strains was. ... endogenous DivIVA through dimerization or oligomerization. When localization of wild-type DivIVA-GFP was analysed in. -
REPORT◥ PROTEOSTASIS UBE2O is a quality control factor fororphans ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Science_2017b.pdf4 Aug 2017: Catalytically inactive UBE2O(C1040S) alsorecovered endogenous and exogenous RPL24(but no detectable ubiquitinated forms), whereasUBE2O(DCR2) interacted poorly with RPL24 (fig.S10D). ... The heterogeneity of ubiquitin bands in the samples with cytosol is -
554 Research Paper Inhibition of receptor-mediated endocytosis by the …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/wigge_McMahon1997.pdf21 Mar 2003: The most likely explanation for this is that theinteraction of dynamin with endogenous amphiphysin wasdisrupted in these cells. ... J Cell Biol 1993, 127:725-735. 18. Tuma PL, Stachniak MC, Collins CA: Activation of dynamin GTPaseby acidic phospholipids -
Supplementary Figure 1Lysophosphatidic acid acyl transferase (LPAAT)…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/GallopEndoSupFigs.pdf4 Jan 2006: various endophilins and controls. a. b. c. Transformation of JC201 bacteria with endophilin does not lead to an acceleration of growth kinetics, unlike transformation of the endogenous LPAAT. -
The structural basis of novel endosome anchoringactivity of KIF16B ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17641687.pdf23 Jul 2007: performed dual immunofluorescence staining of expressed. KIF16B-PX and endogenous EEA1 using fixed HEK293 cells. ... In agreement with A431 cell localization, KIF16B-PX was. colocalized with endogenous EEA1 (Figure 6A). -
doi:10.1016/j.devcel.2004.09.003
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15469844.pdf1 Nov 2004: InhVps37A and hVps37B (Bache et al., 2004; Stuchell et al.,addition, they play a critical role in retrovirus budding.2004), while the human ESCRT-II subunits correspondStructural understanding of ESCRT interaction ... The CCP4 suite: Morita, E., and -
The ER membrane protein complex promotes biogenesis of sterol-related …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/JCS_2019.pdf18 Jan 2019: SQS insertion by EMC enables sterol biosynthesisTo determine the mechanism responsible for downregulating SQSin EMC-knockout cells, we monitored endogenous SQS synthesisand turnover by performing 35S-Met/Cys pulse-chase assays. ... A) 35S-Met/Cys -
tra_578 1..18
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Burtey%20IVF%20Traffic%2007.pdf15 May 2007: colocalizing with endogenous AP-2 complexes (Figure 2. G–J). In contrast, the IVA mutation resulted in complete. ... plasma membrane (Figure 5A), which colocalized with both. clathrin–DsRed and endogenous AP-2 complexes (Figure 5. -
cm6307.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TAXOL.C&B.pdf18 Feb 1999: Such molecules mightmimic an endogenous cellular factor, presumably a lesspotent one, that helps to stabilise microtubules in normalcytoplasm; the natural reagent might be a small molecule orpart of a microtubule-associated -
pnas201206839 17424..17429
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/23045692.pdf21 Nov 2012: Depletion of endogenous MITD1with two independent small interfering RNAs (siRNAs) resultedin phenotypes consistent with cytokinesis failure, as indicated bya six- to eightfold increase of multinucleated cells compared withcontrol siRNA-transfected -
A Ubiquitin Ligase-Associated Chaperone Holdase Maintains…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/72_Wang_Q_Mol_Cell_2011.pdf23 May 2012: IB, immunoblot-. ting. (B and C) Endogenous interactions between the. Bag6 and the gp78-p97 complexes. ... Trc35 Maintains a Cytosolic Pool of Bag6(A) Trc35 expression alters the subcellular localization of endogenous Bag6. -
Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and…
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-4.pdf30 Jun 2015: Under these conditions, we only observed endogenous acetylcholine EPSCs. To recordGABAergic postsynaptic currents, the holding potential was 0 mV, at which we only observemIPSCs. ... Supporting InformationS1 Fig. Stimulus-evoked EPSCs and endogenous -
No Job Name
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/vandenent2008ftsq.pdf4 Mar 2008: As shown in Fig. 5, WTFtsQ expressed together with sYFP1-FtsL in LMC531cells (that contain the endogenous temperature-sensitivemutation E125K) target FtsL to midcell at both 28C and42C (Fig. ... The resulting strains wereconfirmed by PCR analysis,
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