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28 Feb 2023: Overexpression of wild-type transthyre-tin in the APP23 mouse model of AD reduced cognitive and motor impairments, whereas silencing of the endogenous transthyretin gene promoted neuropathology76. ... Inspired by this mechanism, endogenous internal-izing

15 Jan 2012: New research reveals that cell stress acts as a stimulus for double phosphorylation of endogenous Htt, causing its nuclear translocation, and shows that certain chemicals can target such molecular processes in

4 Feb 2020: 33. E. W. J. Wallace et al., Reversible, specific, active aggregates of endogenous proteinsassemble upon heat stress. ... Taylor, IbpA and IbpB, the new heat-shock proteins,bind to endogenous Escherichia coli proteins aggregated intracellularly by

25 Feb 2014: Targeting the Intrinsically Disordered StructuralEnsemble of a-Synuclein by Small Molecules as aPotential Therapeutic Strategy for Parkinson’s DiseaseGergely Tóth1,4, Shyra J. Gardai4, Wagner Zago4, Carlos W. Bertoncini1,2, Nunilo Cremades1,.

27 Jun 2009: A deletion mutantof recombinant mouse PrP (moPrPC Δ114–121) doesnot readily aggregate and indeed is able to inhibit theconversion of endogenous wild-type PrPC into PrPScin scrapie-infected mouse neuroblastoma

1 Mar 2015: 3E). These results suggestthe possibility that endogenous wild-type PKCg could formamyloid-like aggregates in vivo. ... These previous studies as well as the current onesuggest that some fractions of endogenous PKC isoformsmight form amyloid-like

4 Feb 2020: Tbc1d15 Epb4.1l3. Rbm42. Trim16. Fig. 2. Impact of a Httex1 mutation and subsequent aggregation on solubility of endogenous proteins.

28 Feb 2023: The endogenous proteins that are sequestered by the aggregates share distinct physicochemical properties: They are relatively large in size and significantly enriched in predicted unstructured regions, features that are strongly linked

2 Mar 2023: We tested human endogenous fat-soluble(red) and water-soluble (blue) vitamin metabolites in a ThT-basedscreen to identify vitamin metabolites that either accelerate or delaythe aggregation of Aβ42. ... Togetherwith the C. elegans experiments, these data

28 Sep 2021: REVIEW ARTICLE OPEN. The Amyloid-β Pathway in Alzheimer’s DiseaseHarald Hampel 1, John Hardy2, Kaj Blennow3,4, Christopher Chen 5, George Perry 6, Seung Hyun Kim7,Victor L. Villemagne 8,9, Paul Aisen10, Michele Vendruscolo 11, Takeshi Iwatsubo12,