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Fig. 1 Glutathione depletion sensitizes pancreatic β-cells to endogenous H2O2. a Absorbance at 540 nm (an indicator of cell mass) by cultures ofa β-cell line (RINm5F) or mouse embryonic

4) toinvestigate health states of tissues. The autofluorescence lifetimecharacteristics can be studied by simply exciting endogenous flu-orophores without labels [5,61] at desired wavelengths using aSC source.

More-over, our results showed that exogenously added monomerleads to the induction of endogenous a-synuclein aggregationwithout the two moieties coming into close proximity. ... incubated for 24 h in a-synuclein-free medium and immunostained for

Moreover, wefound that the peptide is able to enter cells andreach the cytoplasmic compartment and specificallyinduce the aggregation of endogenous VEGFR2,inhibiting its function in human umbilical veinendothelial cells (HUVECs) in

endogenous amyloid-b deposition in the hippocampus beginsto appear at 8–10 months of age.

Fig. 6 Uptake of monomeric tau protein into neuron-like cells causes its aggregation and subsequentrecruitment of endogenous tau, normally present in the cell. ... Intriguingly, the cell expels fibrillaraggregates that contain both the ingested K18Tau,

3D), demonstrates that endogenous AS is pref-erentially recruited to elongate exogenous seeds rather thanundergoing nucleation. ... We find that these aggregates have a reducedpropensity to seed endogenous AS relative to preformed ASseed fibrils.

Intriguingly, the cell expunges fibrillar aggregates that contain both the ingested K18Tau, shown in red, and endogenous wild type tau, already present in the cell, shown in green. ... F-1. Figure 5: Uptake of monomeric Tau protein into neuron-like cells

relevance of heparin-promoted amyloid models. The endogenous opiate b-endorphin is an essential neuropeptideinvolved in the stress response of higher organisms.1 In thesecretory pathway, it is temporarily stored in

3c). Next, we studied the behavior of endogenous alpha-synucleinin ventral midbrain (VM) neurons incubated with 100 µMdopamine. ... VM neurons treatedwith dopamine for 72 h were stained against endogenous alpha-synuclein and the synaptic vesicle protein