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Research | Department of Pharmacology
https://www.phar.cam.ac.uk/research/Howarth/research15 May 2024: We have developed a new class of binding proteins that form covalent bonds to endogenous protein targets. -
Phar Cambridge RSS Paper feed | Department of Pharmacology
https://www.phar.cam.ac.uk/aggregator/sources/2215 May 2024: Both are Ca2+-permeable and regulated by phosphoinositides, principally PI(3,5)P2. Accumulating evidence has uncovered synergistic channel activation by PI(3,5)P2 and endogenous metabolites such as the -
Publications | Department of Pharmacology
https://www.phar.cam.ac.uk/research/lindon/pub15 May 2024: Cell density-dependent induction of endogenous myogenin (myf4) gene expression by Myf5. -
Research Interest | Department of Pharmacology
https://www.phar.cam.ac.uk/research/Ladds/research15 May 2024: We are also using new methods to aid in the de-orphanisation (identification of endogenous agonists) for olfactory receptors. -
Dr Cathy Wilson | Department of Pharmacology
https://www.phar.cam.ac.uk/news/wilson15 May 2024: Her main area of research is to develop therapeutic strategies to either inhibit Myc driven transcription to develop new cancer therapies or enhance Myc driven transcription to stimulate endogenous tissue repair. -
Group Summaries for Alumni | Department of Pharmacology
https://www.phar.cam.ac.uk/group-summaries-alumni15 May 2024: derived from the most clinically advanced AURKA inhibitor, alisertib, that are able to clear both endogenous and exogenous AURKA from cells and to downregulate its interphase functions. -
Enterprise and Industry Collaboration | Department of Pharmacology
https://www.phar.cam.ac.uk/enterprise-and-industry-collaboration15 May 2024: mRNA cardiac regenerative therapeutic that drives endogenous healing. Contact us. Department of Pharmacology. -
Designer proteins to seek and destroy | Department of Pharmacology
https://www.phar.cam.ac.uk/news/BBSRC-funded-project15 May 2024: These will be adapted in two applications: First, the disruption of endogenous protein-protein interactions to control and direct cellular processes in which they are involved. -
Previous Seminar Series Talks | Department of Pharmacology
https://www.phar.cam.ac.uk/previous-seminar-series-talks15 May 2024: 17th Febuary. Dr Shafaq Sikander. William Harvey Research Institute. Endogenous and immunological mechanisms of musculoskeletal pain. -
Innovating Protein Technologies for Therapeutic and Vaccine Design |…
https://www.phar.cam.ac.uk/research/Howarth15 May 2024: Nature Nanotechnology. 2023 Mar;18(3):290-298. NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins.
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