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TH EJ OU RN AL OF CE LL BIO ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16785321.pdf12 Nov 2006: TH. EJ. OU. RN. AL. OF. CE. LL. BIO. LO. GY. JCB: ARTICLE. The Rockefeller University Press $8.00The Journal of Cell Biology, Vol. 173, No. 6, June 19, 2006 867–877http://www.jcb.org/cgi/doi/10.1083/jcb.200603153 JCB 867. IntroductionCentrins are -
doi:10.1016/S1097-2765(03)00246-6
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/12887891.pdf5 Sep 2003: Molecular Cell, Vol. 12, 39–50, July, 2003, Copyright 2003 by Cell Press. PB1 Domain-Mediated Heterodimerizationin NADPH Oxidase and Signaling Complexesof Atypical Protein Kinase C with Par6 and p62. al, 2003). The molecular organization of -
npgrj_nchembio_117 691..699
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/18849971.pdf16 Oct 2008: Targeted polypharmacology: discovery of dual inhibitorsof tyrosine and phosphoinositide kinasesBeth Apsel1, Jimmy A Blair2, Beatriz Gonzalez3,6, Tamim M Nazif4, Morri E Feldman1, Brian Aizenstein5,Randy Hoffman5, Roger L Williams3, Kevan M Shokat2,4 -
Tyrosine Residues in Phospholipase C�2 Essential for the…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11606584.pdf20 Apr 2002: Tyrosine Residues in Phospholipase C2 Essential for the EnzymeFunction in B-cell Signaling. Received for publication, August 8, 2001, and in revised form, October 9, 2001Published, JBC Papers in Press, October 17, 2001, DOI 10.1074/jbc.M107577200. -
doi:10.1016/j.molcel.2004.08.004
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15350214.pdf24 Sep 2004: Molecular Cell, Vol. 15, 689–701, September 10, 2004, Copyright 2004 by Cell Press. Structure of a Human Inositol 1,4,5-Trisphosphate3-Kinase: Substrate Binding RevealsWhy It Is Not a Phosphoinositide 3-Kinase. which includes InsP6 kinases -
doi:10.1016/j.str.2008.06.010
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/18786397.pdf3 Sep 2008: Structure. Article. Structure and Disassembly of FilamentsFormed by the ESCRT-III Subunit Vps24Sara Ghazi-Tabatabai,1 Suraj Saksena,2 Judith M. Short,1 Ajaybabu V. Pobbati,1 Dmitry B. Veprintsev,1. R. Anthony Crowther,1 Scott D. Emr,2 Edward H. -
doi:10.1016/j.cell.2006.03.035
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16647110.pdf14 Jun 2006: A Pharmacological Map of the PI3-KFamily Defines a Role for p110ain Insulin SignalingZachary A. Knight,1 Beatriz Gonzalez,4,7 Morri E. Feldman,1 Eli R. Zunder,1 David D. Goldenberg,2. Olusegun Williams,1 Robbie Loewith,5 David Stokoe,3 Andras -
doi:10.1016/j.cell.2006.01.047
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16615893.pdf18 Apr 2006: ESCRT-I Core and ESCRT-II GLUEDomain Structures Reveal Role for GLUEin Linking to ESCRT-I and MembranesHsiangling Teo,1,4, David J. Gill,1,4 Ji Sun,3 Olga Perisic,1 Dmitry B. Veprintsev,2 Yvonne Vallis,1. Scott D. Emr,3 and Roger L. Williams1,1 MRC -
x96411u107
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11136978.pdf1 Dec 2000: Cell, Vol. 103, 931–943, December 8, 2000, Copyright 2000 by Cell Press. Crystal Structure and Functional Analysisof Ras Binding to Its EffectorPhosphoinositide 3-Kinase g. suppression of apoptosis (Franke et al., 1997), reorgani-zation of the -
bst641-09a
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/19614567.pdf2 Aug 2010: Morton. Lecture. Morton LectureForm and flexibility in phosphoinositide 3-kinasesRoger Williams1, Alex Berndt, Simon Miller, Wai-Ching Hon and Xuxiao ZhangMRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K. AbstractPI3Ks -
Structural and Membrane Binding Analysis of the PhoxHomology Domain…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17581820.pdf8 Dec 2007: Structural and Membrane Binding Analysis of the PhoxHomology Domain of Bem1pBASIS OF PHOSPHATIDYLINOSITOL 4-PHOSPHATE SPECIFICITYSReceived for publication, April 4, 2007, and in revised form, May 29, 2007 Published, JBC Papers in Press, June 20, 2007 -
cdf519 5057..5068
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/12356722.pdf12 Oct 2002: Dimitrios Karathanassis1,Robert V.Stahelin2, Jero nimo Bravo1,3,Olga Perisic1, Christine M.Pacold1,Wonhwa Cho2 and Roger L.Williams1,4. 1MRC Laboratory of Molecular Biology, Hills Road,Cambridge CB2 2QH, UK and 2Department of Chemistry,University -
Structural insight into the ESCRT-I/-II link and itsrole in ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17215868.pdf14 Jun 2007: Structural insight into the ESCRT-I/-II link and itsrole in MVB trafficking. David J Gill1,, Hsiangling Teo1, Ji Sun2,Olga Perisic1, Dmitry B Veprintsev3,Scott D Emr2 and Roger L Williams1. 1MRC Laboratory of Molecular Biology, Medical Research -
M6_07079a2
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17038310.pdf12 Nov 2006: Stahelin et al. 1. Structural and Membrane Binding Analysis of the PX Domain of Phosphoinositide 3-Kinase-C2α. Robert V. Stahelin1, Dimitrios Karathanassis2,5, Karol S. Bruzik3, Michael D. Waterfield4, Jerónimo. Bravo2,6, Roger L. Williams2 and -
PII: S1097-2765(03)00356-3
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/gripdomain.pdf27 Oct 2003: Molecular Cell, Vol. 12, 863–874, October, 2003, Copyright 2003 by Cell Press. Structural Basis for Arl1-Dependent Targeting ofHomodimeric GRIP Domains to the Golgi Apparatus. elle (Donaldson and Jackson, 2000). For example, Arf1recruits COP I -
Paul EmsleyMRC Laboratory of Molecular Biology, Cambridge, UKJune…
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/Ligands-July-2015-v2.pdf16 Jul 2015: One by one download the wwPDB definition mmcif. – Total: 15168. – ... Download all these minimal descriptions and run Acedrg. – 7360 cif files generated (93% coverage). -
nrm2162.indd
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17450176.pdf14 Jun 2007: Many plasma-membrane proteins are in a constant flux throughout the internal trafficking pathways of the cell. Some receptors, such as that for transferrin, are continuously internalized into recycling endosomes and returned to the cell surface. -
tutorial-2.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/tutorial-2.pdf16 May 2010: Do you prefer that? Why? Use the EDS service to download 1H4P. -
Dbouk 1..13
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/vadas_science_signaling.pdf5 Dec 2012: 253), ra89. [DOI: 10.1126/scisignal.2003264] 5Science SignalingRoger L. Williams and Jonathan M. Backer (4 December 2012) Harden, Alan V. Smrcka, Ronald Taussig, Anne R. Bresnick, Bernd Nürnberg, Christine Hsueh, Olga Perisic, Christian Harteneck, -
LMB-Timeline-poster 2020 - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fdownload%2Flmb-timeline-poster-2019%2F&format=xmlcam.ac.uk/download/lmb-timeline-poster-2019/">LMB-Timeline-poster 2020</a></blockquote><iframe sandbox="allow-scripts" security="restricted" -
Briggs SARS-CoV-2 Image - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fdownload%2Fbriggs-nature-cover%2F&format=xmlcam.ac.uk/download/briggs-nature-cover/">Briggs SARS-CoV-2 Image</a></blockquote><iframe sandbox="allow-scripts" security="restricted" -
Getting on your Nerves
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2012/media/GettingOnYourNerves.pptx22 Feb 2012: Getting on your Nerves. What a lot of nerve! There are about 100,000,000,000 neurons in an adult human. These form 10,000,000,000,000 synapses, or connections. They represent 2% of the body’s weight, 0.04-0.07% cells and 20-44% of the body’s -
A ribosome-associating factor chaperones tail-anchored membrane…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/66_Mariappan_M_Nature_2010.pdf1 Aug 2010: LETTERS. A ribosome-associating factor chaperonestail-anchored membrane proteinsMalaiyalam Mariappan1, Xingzhe Li1,2, Sandra Stefanovic1, Ajay Sharma1, Agnieszka Mateja3, Robert J. Keenan3. & Ramanujan S. Hegde1. Hundreds of proteins are inserted -
Coot Updates Paul EmsleySept 2016 Coot 0.8.4 Released● Patterson ...
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/emsley-ccp4-ligand-meeting-sept-2016-v5.pdf28 Sep 2016: Search” comp_id (2GM) Download $ pyrogen -Mn --comp_id AAA -R 2GM.cif problem-2.smi. -
Doc2b Is a High-Affinity Ca2+ Sensor forSpontaneous Neurotransmitter…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/GroffenScience2010.pdf30 Apr 2010: Doc2b Is a High-Affinity Ca2+ Sensor forSpontaneous Neurotransmitter ReleaseAlexander J. Groffen,1 Sascha Martens,2† Rocío Díez Arazola,1 L. Niels Cornelisse,1Natalia Lozovaya,1,3,4 Arthur P. H. de Jong,1 Natalia A. Goriounova,1,3 Ron L. P. -
PowerPoint Presentation
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/Interactomes/NetworkWebTalk_files/NetworkWebTalk.html.ppt21 Aug 2007: Dynamic networks. &. clathrin-mediated. endocytosis. Gerrit Praefcke. (now at Cologne). Marijn Ford. (now at UC Davis). Eva Schmid. (LMB Cambridge). The Interactome web pages were written to accompany Schmid and McMahon (Nature 2007) and this talk -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/1034
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/1034Can either use user-supplied homologous structures, or run an automated BLAST search and download homologues from the PDB. -
80096 RPF
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/EMBO2012FtsAPiotr/emboj201276s3.pdf7 Mar 2012: The EMBO Journal Peer Review Process File - EMBO-2011-80096. European Molecular Biology Organization 1. Manuscript EMBO-2011-80096 FtsA forms actin-like protofilaments Piotr Szwedziak, Qing Wang, Stefan MV Freund and Jan Löwe Corresponding author: -
Books - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/books/21 Jul 2023: Electronic versions available to download;.
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Greger Lab
https://www2.mrc-lmb.cam.ac.uk/groups/greger/feed/25 Aug 2023: pdf" class="wp-block-file__button" download aria-describedby="wp-block-file--media-ca71a40f-cb52-470f-8983-e1dd9a5eb09b"Download/a/div -
Coot Tools for Cryo-EM Paul EmsleyMRC Laboratory of Molecular ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-Aug-Stockholm.pdf15 Aug 2018: Download Binaries pre-release experimental. Model-Building Tools. Recent Developments. 8/90. Model-Building Tools. -
Manipulating Ligands Using Coot with a bit of carbohydrates ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/coot-may-2017-ligands-madrid-mcs2017-csic.pdf10 May 2017: downloads and reads (e.g.) AAA.cif (extracted from chemical component library). Drag and drop Uses network connection to get URLs or file-system files. -
PowerPoint Presentation
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2014/media/Changing_Brains_Neurotechnology_website.pptx2 May 2013: Changing Brains. Neurotechnology The Artificial Brain? Medical Electronics. Nervous System. Neurotechnology is any technology that improves or repairs nervous system function or facilitates understanding of the nervous system. Brain-machine -
coot-user-manual.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/docs/coot-user-manual.pdf28 Sep 2012: 21. 4.6 Download coordinates. 214.7 Get Coordinates and Map from EDS. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/wpdmpro/18725
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/wpdmpro/1872503-30T13:27:49","modified_gmt":"2021-03-30T12:27:49","slug":"covid19-image-download","status":"publish","type":"wpdmpro","link":"https://www2.mrc-lmb.cam.ac.uk/download/covid19-image-download/"," -
Insights into how the Fanconi Anaemia core complex activates DNA…
https://www2.mrc-lmb.cam.ac.uk/insights-into-how-the-fanconi-anaemia-core-complex-activates-dna-repair/6 Jun 2014: Research carried out by Eeson Rajendra from Lori Passmore’s group in the LMB’s Structural Studies Division, in close collaboration with KJ Patel from the
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Who we are
https://www2.mrc-lmb.cam.ac.uk/groups/worms/who-we-are/Who we are. Worms are cleverer than you think! was started by Dr. Kristin Webster and Dr. Denise Walker , neuroscientists at the Medical Research Council’s Laboratory of Molecular Biology (MRC LMB), a research institute in Cambridge, UK. We think -
LMB and AstraZeneca announce plan to launch joint research fund - MRC …
https://www2.mrc-lmb.cam.ac.uk/lmb-and-astrazeneca-announce-plan-to-launch-joint-research-fund/15 May 2014: The MRC Laboratory of Molecular Biology and AstraZeneca are today announcing a plan for a research fund to facilitate collaboration between LMB and
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Mammalian clock gene Cryptochrome 1 is crucial to suprachiasmatic…
https://www2.mrc-lmb.cam.ac.uk/mammalian-clock-gene-cryptochrome-1-is-crucial-to-suprachiasmatic-nucleus-timekeeping/31 Aug 2022: Using translational switching, Michael Hastings’ group has shown that the mammalian clock gene Cryptochrome 1 is a state variable and core phase setting component of the brain’s master clock.
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Videos
https://www2.mrc-lmb.cam.ac.uk/groups/ribo/resources/videos/Download. (49.9 MiB).. -
Useful links
https://www2.mrc-lmb.cam.ac.uk/groups/worms/other-resources/Useful links. Wormbook– a great introduction to using C. elegans in scientific research. Wormclassroom– collection of other C. elegans education and outreach activities. CGC– the Caenorhabditis Genetics Center- you can order C. elegans strains -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/wpdmpro/18836
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/wpdmpro/18836{"id":18836,"date":"2020-08-10T12:37:36","date_gmt":"2020-08-10T11:37:36","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/download/lmb-timeline-poster-2019/"},"modified":"2021- ... 07-07T15:05:53","modified_gmt":"2021-07-07T14:05:53","slug":"lmb-timeli -
McMahon Group publications
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/papers.html20 Mar 2023: Web pages have been written to accompany this review including movies you can download. -
PowerPoint Presentation
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2014/media/Changing_Brains_The_Teenage_Brain_website.pptx2 May 2013: Changing Brains. The. Teenage. Brain. Our youth now love luxury. They have bad manners, contempt for authority; they show disrespect for their elders and love chatter in place of exercise; they no longer rise when elders enter the room; they -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/11886
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/11886package_1"n div class='row'div class='col-lg-12 col-md-12 col-12'a ... Molecular Replacement – Airlie McCoy/h3nnnnul class="wp-block-list"nliRequired Software – a href="http://www.ccp4.ac.uk/download/index.php" target="_blank" rel="noopener -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/2800
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/2800{"id":2800,"date":"2012-09-12T10:49:57","date_gmt":"2012-09-12T09:49:32","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=2800"},"modified":"2023-09-06T14:20:31","modified_gmt":"2023-09-06T13:20:31","slug":"how-to-apply","status": -
https://www2.mrc-lmb.cam.ac.uk/groups/worms/wp-json/wp/v2/pages/11
https://www2.mrc-lmb.cam.ac.uk/groups/worms/wp-json/wp/v2/pages/11lmb.cam.ac.uk/groups/worms/download/Old-worms_worksheet.pdf" What happens when worms get old? ... worms!/a/lin/uln","protected":false},"excerpt":{"rendered":"pBelow you can you download PDFs of all of our materials. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/7578
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/7578To read about these stories and others, please download the pdf “. -
> Home > Courses LMB Crystallography Course April-June 2013 ...
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses.html4 Dec 2019: >LMB Cryo-EM Model Building And Refinement Workshop, December 2019. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/1205339
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/1205339{"id":1205339,"date":"2024-01-31T14:31:57","date_gmt":"2024-01-31T14:31:55","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/recruitment/rising-talent-fellowship/"},"modified":"2024-04-02T16:52:09","modified_gmt":"2024-04-02T15:52:09","slug":"risin
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