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x96255u149
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11090628.pdf20 Apr 2002: Molecular Cell, Vol. 6, 909–919, October, 2000, Copyright 2000 by Cell Press. Structural Determinants of Phosphoinositide3-Kinase Inhibition by Wortmannin, LY294002,Quercetin, Myricetin, and Staurosporine. for proteins such as protein kinase B -
Structural and Mechanistic Comparison of Prokaryotic and Eukaryotic…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9466937.pdf15 Jan 1998: Structural and Mechanistic Comparison of Prokaryoticand Eukaryotic Phosphoinositide-specificPhospholipases C. Dirk W. Heinz1, Lars-Oliver Essen2 and Roger L. Williams3. 1Institut fuÈ r OrganischeChemie und BiochemieUniversitaÈt -
Structural Mapping of the Catalytic Mechanism for a…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9048554.pdf20 Apr 2002: Structural Mapping of the Catalytic Mechanism for a MammalianPhosphoinositide-Specific Phospholipase C†,‡. Lars-Oliver Essen,,| Olga Perisic, Matilda Katan, Yiqin Wu, Mary F. Roberts, and Roger L. Williams,. Centre for Protein Engineering, MRC -
©20 10 N atur e A mer ica, Inc. ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20081827.pdf2 Aug 2010: 20. 10 N. atur. e A. mer. ica,. Inc. All. righ. ts r. eser. ved. NATURE CHEMICAL BIOLOGY | VOL 6 | FEBRUARY 2010 | www.nature.com/naturechemicalbiology 1 1 7. ARTICLEPUBLISHED ONLINE: 10 JANUARY 2010 | DOI: 10.1038/NCHEMBIO.293. The PI(3)Ks are -
The structural basis of novel endosome anchoringactivity of KIF16B ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17641687.pdf23 Jul 2007: The structural basis of novel endosome anchoringactivity of KIF16B kinesin. Nichole R Blatner1, Michael I Wilson2,Cai Lei3, Wanjin Hong3, Diana Murray4,Roger L Williams2 and Wonhwa Cho 1,1Department of Chemistry, University of Illinois at Chicago, -
doi:10.1016/S1097-2765(03)00246-6
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/12887891.pdf5 Sep 2003: Molecular Cell, Vol. 12, 39–50, July, 2003, Copyright 2003 by Cell Press. PB1 Domain-Mediated Heterodimerizationin NADPH Oxidase and Signaling Complexesof Atypical Protein Kinase C with Par6 and p62. al, 2003). The molecular organization of -
Covid19 Image - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fdownload%2Fcovid19-image-download%2F&format=xmlcam.ac.uk/download/covid19-image-download/">Covid19 Image</a></blockquote><iframe sandbox="allow-scripts" security="restricted" -
TH EJ OU RN AL OF CE LL BIO ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16785321.pdf12 Nov 2006: TH. EJ. OU. RN. AL. OF. CE. LL. BIO. LO. GY. JCB: ARTICLE. The Rockefeller University Press $8.00The Journal of Cell Biology, Vol. 173, No. 6, June 19, 2006 867–877http://www.jcb.org/cgi/doi/10.1083/jcb.200603153 JCB 867. IntroductionCentrins are -
Tyrosine Residues in Phospholipase C�2 Essential for the…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11606584.pdf20 Apr 2002: Tyrosine Residues in Phospholipase C2 Essential for the EnzymeFunction in B-cell Signaling. Received for publication, August 8, 2001, and in revised form, October 9, 2001Published, JBC Papers in Press, October 17, 2001, DOI 10.1074/jbc.M107577200. -
npgrj_nchembio_117 691..699
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/18849971.pdf16 Oct 2008: Targeted polypharmacology: discovery of dual inhibitorsof tyrosine and phosphoinositide kinasesBeth Apsel1, Jimmy A Blair2, Beatriz Gonzalez3,6, Tamim M Nazif4, Morri E Feldman1, Brian Aizenstein5,Randy Hoffman5, Roger L Williams3, Kevan M Shokat2,4 -
doi:10.1016/j.molcel.2004.08.004
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15350214.pdf24 Sep 2004: Molecular Cell, Vol. 15, 689–701, September 10, 2004, Copyright 2004 by Cell Press. Structure of a Human Inositol 1,4,5-Trisphosphate3-Kinase: Substrate Binding RevealsWhy It Is Not a Phosphoinositide 3-Kinase. which includes InsP6 kinases -
x96411u107
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11136978.pdf1 Dec 2000: Cell, Vol. 103, 931–943, December 8, 2000, Copyright 2000 by Cell Press. Crystal Structure and Functional Analysisof Ras Binding to Its EffectorPhosphoinositide 3-Kinase g. suppression of apoptosis (Franke et al., 1997), reorgani-zation of the -
doi:10.1016/j.str.2008.06.010
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/18786397.pdf3 Sep 2008: Structure. Article. Structure and Disassembly of FilamentsFormed by the ESCRT-III Subunit Vps24Sara Ghazi-Tabatabai,1 Suraj Saksena,2 Judith M. Short,1 Ajaybabu V. Pobbati,1 Dmitry B. Veprintsev,1. R. Anthony Crowther,1 Scott D. Emr,2 Edward H. -
Structural and Membrane Binding Analysis of the PhoxHomology Domain…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17581820.pdf8 Dec 2007: Structural and Membrane Binding Analysis of the PhoxHomology Domain of Bem1pBASIS OF PHOSPHATIDYLINOSITOL 4-PHOSPHATE SPECIFICITYSReceived for publication, April 4, 2007, and in revised form, May 29, 2007 Published, JBC Papers in Press, June 20, 2007 -
doi:10.1016/j.cell.2006.03.035
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16647110.pdf14 Jun 2006: A Pharmacological Map of the PI3-KFamily Defines a Role for p110ain Insulin SignalingZachary A. Knight,1 Beatriz Gonzalez,4,7 Morri E. Feldman,1 Eli R. Zunder,1 David D. Goldenberg,2. Olusegun Williams,1 Robbie Loewith,5 David Stokoe,3 Andras -
doi:10.1016/j.cell.2006.01.047
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16615893.pdf18 Apr 2006: ESCRT-I Core and ESCRT-II GLUEDomain Structures Reveal Role for GLUEin Linking to ESCRT-I and MembranesHsiangling Teo,1,4, David J. Gill,1,4 Ji Sun,3 Olga Perisic,1 Dmitry B. Veprintsev,2 Yvonne Vallis,1. Scott D. Emr,3 and Roger L. Williams1,1 MRC -
bst641-09a
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/19614567.pdf2 Aug 2010: Morton. Lecture. Morton LectureForm and flexibility in phosphoinositide 3-kinasesRoger Williams1, Alex Berndt, Simon Miller, Wai-Ching Hon and Xuxiao ZhangMRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K. AbstractPI3Ks -
Structural insight into the ESCRT-I/-II link and itsrole in ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17215868.pdf14 Jun 2007: Structural insight into the ESCRT-I/-II link and itsrole in MVB trafficking. David J Gill1,, Hsiangling Teo1, Ji Sun2,Olga Perisic1, Dmitry B Veprintsev3,Scott D Emr2 and Roger L Williams1. 1MRC Laboratory of Molecular Biology, Medical Research -
cdf519 5057..5068
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/12356722.pdf12 Oct 2002: Dimitrios Karathanassis1,Robert V.Stahelin2, Jero nimo Bravo1,3,Olga Perisic1, Christine M.Pacold1,Wonhwa Cho2 and Roger L.Williams1,4. 1MRC Laboratory of Molecular Biology, Hills Road,Cambridge CB2 2QH, UK and 2Department of Chemistry,University -
M6_07079a2
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17038310.pdf12 Nov 2006: Stahelin et al. 1. Structural and Membrane Binding Analysis of the PX Domain of Phosphoinositide 3-Kinase-C2α. Robert V. Stahelin1, Dimitrios Karathanassis2,5, Karol S. Bruzik3, Michael D. Waterfield4, Jerónimo. Bravo2,6, Roger L. Williams2 and -
PII: S1097-2765(03)00356-3
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/gripdomain.pdf27 Oct 2003: Molecular Cell, Vol. 12, 863–874, October, 2003, Copyright 2003 by Cell Press. Structural Basis for Arl1-Dependent Targeting ofHomodimeric GRIP Domains to the Golgi Apparatus. elle (Donaldson and Jackson, 2000). For example, Arf1recruits COP I -
nrm2162.indd
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17450176.pdf14 Jun 2007: Many plasma-membrane proteins are in a constant flux throughout the internal trafficking pathways of the cell. Some receptors, such as that for transferrin, are continuously internalized into recycling endosomes and returned to the cell surface. -
Paul EmsleyMRC Laboratory of Molecular Biology, Cambridge, UKJune…
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/Ligands-July-2015-v2.pdf16 Jul 2015: One by one download the wwPDB definition mmcif. – Total: 15168. – ... Download all these minimal descriptions and run Acedrg. – 7360 cif files generated (93% coverage). -
tutorial-2.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/tutorial-2.pdf16 May 2010: Do you prefer that? Why? Use the EDS service to download 1H4P. -
Dbouk 1..13
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/vadas_science_signaling.pdf5 Dec 2012: 253), ra89. [DOI: 10.1126/scisignal.2003264] 5Science SignalingRoger L. Williams and Jonathan M. Backer (4 December 2012) Harden, Alan V. Smrcka, Ronald Taussig, Anne R. Bresnick, Bernd Nürnberg, Christine Hsueh, Olga Perisic, Christian Harteneck, -
AP2 adaptors for clathrin-mediated endocytosis: These are Cargo…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/Adaptors/index.html26 Sep 2011: Classical adaptors: e.g. the AP2 adaptor complex. appendages). The hinge domains bind to clathrin terminal domains. AP1, AP3 and AP4 adaptors have similar subunit compositions and bind to different cargo and accessory proteins (see Adaptor table 1). -
LMB-Timeline-poster 2020 - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fdownload%2Flmb-timeline-poster-2019%2F&format=xmlcam.ac.uk/download/lmb-timeline-poster-2019/">LMB-Timeline-poster 2020</a></blockquote><iframe sandbox="allow-scripts" security="restricted" -
Briggs SARS-CoV-2 Image - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fdownload%2Fbriggs-nature-cover%2F&format=xmlcam.ac.uk/download/briggs-nature-cover/">Briggs SARS-CoV-2 Image</a></blockquote><iframe sandbox="allow-scripts" security="restricted" -
Getting on your Nerves
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2012/media/GettingOnYourNerves.pptx22 Feb 2012: Getting on your Nerves. What a lot of nerve! There are about 100,000,000,000 neurons in an adult human. These form 10,000,000,000,000 synapses, or connections. They represent 2% of the body’s weight, 0.04-0.07% cells and 20-44% of the body’s -
A ribosome-associating factor chaperones tail-anchored membrane…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/66_Mariappan_M_Nature_2010.pdf1 Aug 2010: LETTERS. A ribosome-associating factor chaperonestail-anchored membrane proteinsMalaiyalam Mariappan1, Xingzhe Li1,2, Sandra Stefanovic1, Ajay Sharma1, Agnieszka Mateja3, Robert J. Keenan3. & Ramanujan S. Hegde1. Hundreds of proteins are inserted -
Coot Updates Paul EmsleySept 2016 Coot 0.8.4 Released● Patterson ...
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/emsley-ccp4-ligand-meeting-sept-2016-v5.pdf28 Sep 2016: Search” comp_id (2GM) Download $ pyrogen -Mn --comp_id AAA -R 2GM.cif problem-2.smi. -
Doc2b Is a High-Affinity Ca2+ Sensor forSpontaneous Neurotransmitter…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/GroffenScience2010.pdf30 Apr 2010: Doc2b Is a High-Affinity Ca2+ Sensor forSpontaneous Neurotransmitter ReleaseAlexander J. Groffen,1 Sascha Martens,2† Rocío Díez Arazola,1 L. Niels Cornelisse,1Natalia Lozovaya,1,3,4 Arthur P. H. de Jong,1 Natalia A. Goriounova,1,3 Ron L. P. -
PowerPoint Presentation
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/Interactomes/NetworkWebTalk_files/NetworkWebTalk.html.ppt21 Aug 2007: Dynamic networks. &. clathrin-mediated. endocytosis. Gerrit Praefcke. (now at Cologne). Marijn Ford. (now at UC Davis). Eva Schmid. (LMB Cambridge). The Interactome web pages were written to accompany Schmid and McMahon (Nature 2007) and this talk -
80096 RPF
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/EMBO2012FtsAPiotr/emboj201276s3.pdf7 Mar 2012: The EMBO Journal Peer Review Process File - EMBO-2011-80096. European Molecular Biology Organization 1. Manuscript EMBO-2011-80096 FtsA forms actin-like protofilaments Piotr Szwedziak, Qing Wang, Stefan MV Freund and Jan Löwe Corresponding author: -
Coot Tools for Cryo-EM Paul EmsleyMRC Laboratory of Molecular ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-Aug-Stockholm.pdf15 Aug 2018: Download Binaries pre-release experimental. Model-Building Tools. Recent Developments. 8/90. Model-Building Tools. -
Manipulating Ligands Using Coot with a bit of carbohydrates ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/coot-may-2017-ligands-madrid-mcs2017-csic.pdf10 May 2017: downloads and reads (e.g.) AAA.cif (extracted from chemical component library). Drag and drop Uses network connection to get URLs or file-system files. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/11886
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/11886package_1"n div class='row'div class='col-lg-12 col-md-12 col-12'a ... Molecular Replacement – Airlie McCoy/h3nnnnul class="wp-block-list"nliRequired Software – a href="http://www.ccp4.ac.uk/download/index.php" target="_blank" rel="noopener -
> Home > Software > BALBES > Download
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/download_fs/dow_nav.html31 Jan 2012: -
PowerPoint Presentation
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2014/media/Changing_Brains_Neurotechnology_website.pptx2 May 2013: Changing Brains. Neurotechnology The Artificial Brain? Medical Electronics. Nervous System. Neurotechnology is any technology that improves or repairs nervous system function or facilitates understanding of the nervous system. Brain-machine -
Worms are cleverer than you think! – Just another LMB Group Multi…
https://www2.mrc-lmb.cam.ac.uk/groups/worms/Just another LMB Group Multi Sites site -
coot-user-manual.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/docs/coot-user-manual.pdf28 Sep 2012: 21. 4.6 Download coordinates. 214.7 Get Coordinates and Map from EDS. -
Scheres lab
https://www2.mrc-lmb.cam.ac.uk/groups/scheres/publications.html23 Jul 2024: Our publications. 2024. A. Burt, B. Toader, R. Warshmanage, A. von Kugelgen, E. Pyle, J. Zivanov, D. Kimanius, T.A.M. Bharat & S.H.W. Scheres (2024) "An image processing pipeline for electron cryo-tomography in RELION-5". bioRxiv 2024.04.26.591129. -
Resources
https://www2.mrc-lmb.cam.ac.uk/groups/nagai/resources/See also this repository from Marcin Magnus. Asession.pse. 16.8 MiB. 3322 Downloads. ... Category:. PyMOL. Date:. 17th November 2017. U4U6U5tri-snRNP.pse. 24.0 MiB. 3431 Downloads. -
Scripts and Tools for EM fitting
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/em_fitting/em_fitting.html21 Apr 2015: You need to download:. - -
Manipulating Ligands Using Coot with a bit of carbohydrates ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/bgu/coot-feb-2018-ligands-carbohydrate-bgu.pdf22 Feb 2018: downloads and reads (e.g.) AAA.cif (extracted from chemical component library). Drag and drop Uses network connection to get URLs or file-system files. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/22876
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/22876class="wp-block-heading has-light-gray-color has-text-color has-background" id="images" style="background-color:#2e2d61"Images to download/h2nnnndiv class="wp-block-genesis-blocks-gb-columns ... ac.uk/download/covid19-image-download/"Covid19 Image/a/h3n -
Use and misuse of statistics
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_statistics_course_2014/lectures/Lecture1_Intro.pptx23 Feb 2014: They may not be available in the standard R download. Many of them (but not all) are available from the website: http://www.r-project.org/. -
Tutorial: Introduction to RRob Nicholls – nicholls@mrc-lmb.cam.ac.uk…
https://www2.mrc-lmb.cam.ac.uk/download/tutorial-introduction-to-r-rob-nicholls-nichollsmrc-lmb-cam-ac-uk-mrclmbstatistics-course-2014/?wpdmdl=18813&refresh=66a7b6b7e6e8117222673196 Mar 2014: There are a large number of user-created packages available for download, manyof which are available from the R website: www.r-project.org. -
Tutorial: Introduction to RRob Nicholls – nicholls@mrc-lmb.cam.ac.uk…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_statistics_course_2014/tutorials/introduction_to_r.pdf6 Mar 2014: There are a large number of user-created packages available for download, manyof which are available from the R website: www.r-project.org. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/11648
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/11648wpdm_package_1"n div class='row'div class='col-lg-12 col-md-12 col-12'a ... www2.mrc-lmb.cam.ac.uk/download/cryo-em17-lecture-08-modelling/?wpdmdl=18761&refresh=66a7bd7b458b71722269051" class="wpdm-inline-link"Cryo-EM17 Lecture 08 Modelling/a
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