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20 Apr 2002: Molecular Cell, Vol. 6, 909–919, October, 2000, Copyright 2000 by Cell Press. Structural Determinants of Phosphoinositide3-Kinase Inhibition by Wortmannin, LY294002,Quercetin, Myricetin, and Staurosporine. for proteins such as protein kinase B

15 Jan 1998: Structural and Mechanistic Comparison of Prokaryoticand Eukaryotic Phosphoinositide-specificPhospholipases C. Dirk W. Heinz1, Lars-Oliver Essen2 and Roger L. Williams3. 1Institut fuÈ r OrganischeChemie und BiochemieUniversitaÈt

2 Aug 2010: 20. 10 N. atur. e A. mer. ica,. Inc. All. righ. ts r. eser. ved. NATURE CHEMICAL BIOLOGY | VOL 6 | FEBRUARY 2010 | www.nature.com/naturechemicalbiology 1 1 7. ARTICLEPUBLISHED ONLINE: 10 JANUARY 2010 | DOI: 10.1038/NCHEMBIO.293. The PI(3)Ks are

20 Apr 2002: Structural Mapping of the Catalytic Mechanism for a MammalianPhosphoinositide-Specific Phospholipase C†,‡. Lars-Oliver Essen,,| Olga Perisic, Matilda Katan, Yiqin Wu, Mary F. Roberts, and Roger L. Williams,. Centre for Protein Engineering, MRC

23 Jul 2007: The structural basis of novel endosome anchoringactivity of KIF16B kinesin. Nichole R Blatner1, Michael I Wilson2,Cai Lei3, Wanjin Hong3, Diana Murray4,Roger L Williams2 and Wonhwa Cho 1,1Department of Chemistry, University of Illinois at Chicago,

5 Sep 2003: Molecular Cell, Vol. 12, 39–50, July, 2003, Copyright 2003 by Cell Press. PB1 Domain-Mediated Heterodimerizationin NADPH Oxidase and Signaling Complexesof Atypical Protein Kinase C with Par6 and p62. al, 2003). The molecular organization of

12 Nov 2006: TH. EJ. OU. RN. AL. OF. CE. LL. BIO. LO. GY. JCB: ARTICLE. The Rockefeller University Press $8.00The Journal of Cell Biology, Vol. 173, No. 6, June 19, 2006 867–877http://www.jcb.org/cgi/doi/10.1083/jcb.200603153 JCB 867. IntroductionCentrins are

16 Oct 2008: Targeted polypharmacology: discovery of dual inhibitorsof tyrosine and phosphoinositide kinasesBeth Apsel1, Jimmy A Blair2, Beatriz Gonzalez3,6, Tamim M Nazif4, Morri E Feldman1, Brian Aizenstein5,Randy Hoffman5, Roger L Williams3, Kevan M Shokat2,4

20 Apr 2002: Tyrosine Residues in Phospholipase C2 Essential for the EnzymeFunction in B-cell Signaling. Received for publication, August 8, 2001, and in revised form, October 9, 2001Published, JBC Papers in Press, October 17, 2001, DOI 10.1074/jbc.M107577200.

24 Sep 2004: Molecular Cell, Vol. 15, 689–701, September 10, 2004, Copyright 2004 by Cell Press. Structure of a Human Inositol 1,4,5-Trisphosphate3-Kinase: Substrate Binding RevealsWhy It Is Not a Phosphoinositide 3-Kinase. which includes InsP6 kinases

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14 Jun 2006: A Pharmacological Map of the PI3-KFamily Defines a Role for p110ain Insulin SignalingZachary A. Knight,1 Beatriz Gonzalez,4,7 Morri E. Feldman,1 Eli R. Zunder,1 David D. Goldenberg,2. Olusegun Williams,1 Robbie Loewith,5 David Stokoe,3 Andras

18 Apr 2006: ESCRT-I Core and ESCRT-II GLUEDomain Structures Reveal Role for GLUEin Linking to ESCRT-I and MembranesHsiangling Teo,1,4, David J. Gill,1,4 Ji Sun,3 Olga Perisic,1 Dmitry B. Veprintsev,2 Yvonne Vallis,1. Scott D. Emr,3 and Roger L. Williams1,1 MRC

1 Dec 2000: Cell, Vol. 103, 931–943, December 8, 2000, Copyright 2000 by Cell Press. Crystal Structure and Functional Analysisof Ras Binding to Its EffectorPhosphoinositide 3-Kinase g. suppression of apoptosis (Franke et al., 1997), reorgani-zation of the

2 Aug 2010: Morton. Lecture. Morton LectureForm and flexibility in phosphoinositide 3-kinasesRoger Williams1, Alex Berndt, Simon Miller, Wai-Ching Hon and Xuxiao ZhangMRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K. AbstractPI3Ks

3 Sep 2008: Structure. Article. Structure and Disassembly of FilamentsFormed by the ESCRT-III Subunit Vps24Sara Ghazi-Tabatabai,1 Suraj Saksena,2 Judith M. Short,1 Ajaybabu V. Pobbati,1 Dmitry B. Veprintsev,1. R. Anthony Crowther,1 Scott D. Emr,2 Edward H.

8 Dec 2007: Structural and Membrane Binding Analysis of the PhoxHomology Domain of Bem1pBASIS OF PHOSPHATIDYLINOSITOL 4-PHOSPHATE SPECIFICITYSReceived for publication, April 4, 2007, and in revised form, May 29, 2007 Published, JBC Papers in Press, June 20, 2007

14 Jun 2007: Structural insight into the ESCRT-I/-II link and itsrole in MVB trafficking. David J Gill1,, Hsiangling Teo1, Ji Sun2,Olga Perisic1, Dmitry B Veprintsev3,Scott D Emr2 and Roger L Williams1. 1MRC Laboratory of Molecular Biology, Medical Research

12 Oct 2002: Dimitrios Karathanassis1,Robert V.Stahelin2, Jero nimo Bravo1,3,Olga Perisic1, Christine M.Pacold1,Wonhwa Cho2 and Roger L.Williams1,4. 1MRC Laboratory of Molecular Biology, Hills Road,Cambridge CB2 2QH, UK and 2Department of Chemistry,University

12 Nov 2006: Stahelin et al. 1. Structural and Membrane Binding Analysis of the PX Domain of Phosphoinositide 3-Kinase-C2α. Robert V. Stahelin1, Dimitrios Karathanassis2,5, Karol S. Bruzik3, Michael D. Waterfield4, Jerónimo. Bravo2,6, Roger L. Williams2 and