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https://www2.mrc-lmb.cam.ac.uk/microscopes4schools/downloads/protocols
https://www2.mrc-lmb.cam.ac.uk/microscopes4schools/downloads/M4S_activities.pdf11 Mar 2022: Water flea Daphnia pulex. Materials. - glass microscope slides with pre-prepared chamber of electrical tape- plastic cover slips- paper towels or tissue- plastic pipette or dropper- Daphnia pulex collected from a pond/stream or acquired commercially- -
Virus Cards
https://www2.mrc-lmb.cam.ac.uk/viruswars/images/VirusCards_A4.pdf3 Jul 2013: -
Worms are Cleverer than you think! Notes for activities ...
https://www2.mrc-lmb.cam.ac.uk/groups/worms/download/Notes-for-activities-PDF.pdf19 Jan 2018: Worms are Cleverer than you think! Notes for activities. We all appreciate how cool worms are and how powerful they are as a model organism, but. how do we communicate this to the general public? This was our starting point when we decided to design -
JCSG+ Screen
https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB12.pdf2 Oct 2014: Please e-mail, fax or phone your query to Molecular Dimensions. Contact and product details can be found at www.moleculardimensions.com Manufacturer’s safety data sheets are available to download -
Using Coot for model building into EM maps:A tutorial ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/EM-Tutorial-Coot-PE.pdf8 Sep 2015: From http://www.rcsb.org/pdb/explore/explore.do?structureId=4CI0 download the EM map (emd_2513.map). Download the Tutorial data:. ... http://www2.mrclmb.cam.ac.uk/Personal/pemsley/coot/files/BrownTutorial.zip. For reference, download the coordinates for -
Ligand Sketcher Review (Open Source) Rob Nicholls…
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/nicholls-2016_Sept_Ligands.pdf26 Sep 2016: Should be lightweight… maybe. Very much in-development: Ketcher 1 didn’t work out-of-the-box Ketcher 2 download didn’t even include all source… Source is human-readable (unlike -
1 Clear StrategyTM Screen I MD1-14 A 6 × ...
https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB10.pdf2 Oct 2014: Please e-mail, fax or phone your query to Molecular Dimensions. Contact and product details can be found at www.moleculardimensions.com Manufacturer’s safety data sheets are available to download -
Name: than you think! SafetyOur worms, and the bacteria ...
https://www2.mrc-lmb.cam.ac.uk/groups/worms/download/Worms-are-Cleverer-workbook.pdf18 Jan 2018: A. @MRC_LMB (MRC.LMB). using #LMBworms. Big Biology cover download(1). Meet-our-worms download(1). ... Using-senses download(1). Old-worms download(1). -
validation-tutorial.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/validation-tutorial.pdf24 Oct 2017: How might you fix it? 7 Freestyle. Use the EDS to download the structure and data/map for 1BAV. -
Keith_Ligand_Meeting_Dec2016
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/Keith_Ligand_Meeting_Dec2016.pdf9 Dec 2016: Is there anyway one can download the dictionary with restraints etc. -
www.landesbioscience.com Autophagy 805 Autophagy 6:6, 805-807; August …
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20574157.pdf2 Aug 2010: www.landesbioscience.com Autophagy 805. Autophagy 6:6, 805-807; August 16, 2010; 2010 Landes BioscienceAUTOPHAGIC PUNCTUM AUTOPHAGIC PUNCTUM. Key words: Vps34, PI 3-kinase, struc-ture, inhibitor, enzyme, autophagy, Vps15, PtdIns3P, phosphoinositide. -
JCSG+ Screen
https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB11.pdf2 Oct 2014: Please e-mail, fax or phone your query to Molecular Dimensions. Contact and product details can be found at www.moleculardimensions.com Manufacturer’s safety data sheets are available to download -
file:///Users/flong/workplace/balbes_web/MRC-LMB/Webpage/content/balbe…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/documentation_fs/manual_115.pdf9 Feb 2012: LinuxII. Mac OS X. The latest versions can be download at MRC-LMB site or YSBL site. ... 1. Download a version of BALBES database, e.g. BALBES__DB.tar.gz.2. Move the database you have downloaded to the directory where your environment variable. -
tutorial-2.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/tutorial-2.pdf16 May 2010: Do you prefer that? Why? Use the EDS service to download 1H4P. -
LETTERS Structural basis for selective recognition of ESCRT-IIIby the …
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17928861.pdf8 Dec 2007: LETTERS. Structural basis for selective recognition of ESCRT-IIIby the AAA ATPase Vps4Takayuki Obita1, Suraj Saksena2, Sara Ghazi-Tabatabai1, David J. Gill1, Olga Perisic1, Scott D. Emr2. & Roger L. Williams1. The AAA1 ATPases are essential for -
���� ������ � ��� � � ������� ����� ���� ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10856244.pdf6 Jun 2000: "# $. %! & ' () & ,! & ,! " # $ % # & # ' # & & & & # '! - - - -. ,! / 0012+ 3! )! , , 4! , / 005 002+ 3! /62! 3! 78& & &78& & /9) 00%2+ 3! &! & ' /! 82 - /! 8%2+ 8 &! : ,)! )! 78! &! & 3! )! & 4 ; & 9 /2 ,)! & 6 )! )! & /9) 00%2+ ) )! < /= 00>2+. -
tutorial-2.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/tutorial-2.pdf16 May 2010: Do you prefer that? Why? Use the EDS service to download 1H4P. -
Paul EmsleyMRC Laboratory of Molecular Biology, Cambridge, UKJune…
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/Ligands-July-2015-v2.pdf16 Jul 2015: One by one download the wwPDB definition mmcif. – Total: 15168. – ... Download all these minimal descriptions and run Acedrg. – 7360 cif files generated (93% coverage). -
KWRM_A_992668_O
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-3.pdf20 Oct 2015: Download by: [82.6.6.247] Date: 20 October 2015, At: 11:07. Worm. ISSN: (Print) 2162-4054 (Online) Journal homepage: http://www.tandfonline.com/loi/kwrm20. -
Coot Updates Paul EmsleySept 2016 Coot 0.8.4 Released● Patterson ...
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/emsley-ccp4-ligand-meeting-sept-2016-v5.pdf28 Sep 2016: Search” comp_id (2GM) Download $ pyrogen -Mn --comp_id AAA -R 2GM.cif problem-2.smi. -
Calcium-dependent Membrane Penetration Is a Hallmark of theC2 Domain…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9668093.pdf20 Apr 2002: Calcium-dependent Membrane Penetration Is a Hallmark of theC2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domainof Synaptotagmin Binds Membranes Electrostatically. (Received for publication, May 21, 1998). Bazbek Davletov‡, Olga Perisic, -
doi:10.1016/j.cub.2004.07.058
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15296756.pdf6 Oct 2004: Current Biology, Vol. 14, 1380–1384, August 10, 2004, 2004 Elsevier Ltd. All rights reserved. DOI 10.1016/j. c u b. 2 0 0 4. 0 7. 0 5 8. ARAP3 Is a PI3K- and Rap-Regulated GAP for RhoA. Further titration of the relative levels of ARAP3 andSonja -
DOI: 10.1126/science.1165322 , 1710 (2008); 322Science et al.Rachel…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/19008417.pdf18 Dec 2008: DOI: 10.1126/science.1165322 , 1710 (2008); 322Science. et al.Rachel Y. Samson,ArchaeaA Role for the ESCRT System in Cell Division in. www.sciencemag.org (this information is current as of December 18, 2008 ):The following resources related to this -
Coot Tools for Cryo-EM Paul EmsleyMRC Laboratory of Molecular ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-Aug-Stockholm.pdf15 Aug 2018: Download Binaries pre-release experimental. Model-Building Tools. Recent Developments. 8/90. Model-Building Tools. -
DOI: 10.1126/science.1135394 , 239 (2007); 317Science et al.Nabil…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17626883.pdf8 Dec 2007: DOI: 10.1126/science.1135394 , 239 (2007); 317Science. et al.Nabil Miled,the Phosphoinositide 3-Kinase Catalytic SubunitMechanism of Two Classes of Cancer Mutations in. www.sciencemag.org (this information is current as of December 8, 2007 ):The -
Manipulating Ligands Using Coot with a bit of carbohydrates ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/coot-may-2017-ligands-madrid-mcs2017-csic.pdf10 May 2017: downloads and reads (e.g.) AAA.cif (extracted from chemical component library). Drag and drop Uses network connection to get URLs or file-system files. -
Proc. Natl. Acad. Sci. USAVol. 94, pp. 9637–9642, September ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9275175.pdf20 Apr 2002: Proc. Natl. Acad. Sci. USAVol. 94, pp. 9637–9642, September 1997Biophysics. The 2.0-Å resolution crystal structure of a trimeric antibodyfragment with noncognate VH–VL domain pairs shows arearrangement of VH CDR3XUE Y. PEI, PHILIPP HOLLIGER, -
DOI: 10.1126/science.1184429 , 1638 (2010); 327Science et al.Simon…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20339072.pdf2 Aug 2010: DOI: 10.1126/science.1184429 , 1638 (2010); 327Science. et al.Simon Miller,the Structure of the Lipid Kinase Vps34Shaping Development of Autophagy Inhibitors with. This copy is for your personal, non-commercial use only. clicking herecolleagues, -
Phosphoinositide-specific Phospholipase C: Structural Basis for…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10024492.pdf11 Jun 1997: Phosphoinositide-specific phospholipase C: structural basisfor catalysis and regulatory interactionsMatilda Katan and Roger L. Williams. Phosphoinositide-specific phospholipase C (PI-PLC) isozymeshave an important role in cellular responses to a -
Jason William Chin Page 1 of 18 MRC Laboratory ...
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-content/uploads/2024/01/Chin-cv-26012024.pdf29 Jan 2024: Jason William Chin. Page 1 of 18. MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge, CB2 0QH England, UK email: chin@mrc-lmb.cam.ac.uk direct voice: 44 (0)1223 267088 webpage: http://www2.mrc-lmb.cam.ac.uk/ccsb/ Updated: January -
25 Structural studies of phosphoinositide 3-kinase-dependent traffi c …
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17233579_proof.pdf14 Jun 2007: 25. Structural studies of phosphoinositide 3-kinase-dependent traffi c to multivesicular bodiesDavid J. Gill1, Hsiangling Teo1, Ji Sun‡, Olga Perisic, Dmitry B. Veprintsev†, Yvonne Vallis, Scott D. Emr‡ and Roger L. Williams2. MRC Laboratory -
Crystal Structure of the Two N-terminal Domains of g3p from…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10329170.pdf6 May 1999: Article No. jmbi.1999.2720 available online at http://www.idealibrary.com on J. Mol. Biol. (1999) 288, 649657. Crystal Structure of the Two N-terminal Domains ofg3p from Filamentous Phage fd at 1.9 AÊ : Evidence forConformational Lability. Philipp -
Manipulating Ligands Using Coot with a bit of carbohydrates ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/bgu/coot-feb-2018-ligands-carbohydrate-bgu.pdf22 Feb 2018: downloads and reads (e.g.) AAA.cif (extracted from chemical component library). Drag and drop Uses network connection to get URLs or file-system files. -
pnas201205508 15259..15264
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/22949682.pdf25 Nov 2012: Oncogenic mutations mimic and enhance dynamicevents in the natural activation of phosphoinositide3-kinase p110α (PIK3CA)John E. Burke, Olga Perisic, Glenn R. Masson, Oscar Vadas, and Roger L. Williams1. Laboratory of Molecular Biology, Medical -
PII: S1388-1981(99)00150-X
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10570253.pdf20 Apr 2002: Review. Mammalian phosphoinositide-speci¢c phospholipase C. Roger L. Williams Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. Received 1 April 1999 ; received in revised form 17 June 1999 ; accepted 31 -
Crystal Structure of a Calcium-Phospholipid Binding Domainfrom…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9430701.pdf20 Apr 2002: Crystal Structure of a Calcium-Phospholipid Binding Domainfrom Cytosolic Phospholipase A2. (Received for publication, September 24, 1997). Olga Perisic‡, Sun Fong, Denise E. Lynch‡, Mark Bycroft, and Roger L. Williams‡. From the ‡Medical -
doi:10.1016/j.coph.2005.03.002
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15963759.pdf12 Nov 2006: Phosphoinositide 3-kinases as drug targets in cancerLen Stephens1, Roger Williams2 and Phillip Hawkins1. The past two years have seen phosphoinositide 3-kinases. (PI3Ks) move from being seen as potential targets for. chemotherapeutics, to one of -
pnas201206839 17424..17429
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/23045692.pdf21 Nov 2012: ESCRT-III binding protein MITD1 is involved incytokinesis and has an unanticipated PLD foldthat binds membranesMichael A. Haddersa,1, Monica Agromayorb,2,1, Takayuki Obitaa,3, Olga Perisica, Anna Caballeb, Magdalena Klocb,Meindert H. Lamersa, Roger -
Structural Insights into Endosomal Sorting Complex Required…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15044434.pdf24 Sep 2004: Structural Insights into Endosomal Sorting Complex Required forTransport (ESCRT-I) Recognition of Ubiquitinated Proteins. Received for publication, January 5, 2004, and in revised form, March 22, 2004Published, JBC Papers in Press, March 24, 2004, -
N402_18f 313..320
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10580505.pdf11 Nov 1999: 1999 Macmillan Magazines Ltd. letters to nature. NATURE | VOL 402 | 18 NOVEMBER 1999 | www.nature.com 313. 12. Macleod, K. F. et al. p53-dependent and independent expression of p21 during cell growth,. differentiation, and DNA damage. Genes Dev. 9, -
A Ternary Metal Binding Site in the C2 Domain ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9062102.pdf20 Apr 2002: A Ternary Metal Binding Site in the C2 Domain of Phosphoinositide-SpecificPhospholipase C-δ1†,‡. Lars-Oliver Essen,,| Olga Perisic, Denise E. Lynch, Matilda Katan, and Roger L. Williams,. Centre for Protein Engineering, MRC Centre, Hills Road, -
bc219914979p
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10329700.pdf20 Apr 2002: Mapping the Phospholipid-binding Surface and TranslocationDeterminants of the C2 Domain from Cytosolic Phospholipase A2. (Received for publication, November 9, 1998, and in revised form, January 14, 1999). Olga Perisic‡, Hugh F. Paterson, Georgina -
Tumour prevention by a single antibody domaintargeting the…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17568777.pdf22 Jul 2007: Tumour prevention by a single antibody domaintargeting the interaction of signal transductionproteins with RAS. Tomoyuki Tanaka, Roger L Williamsand Terence H Rabbitts. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK. Many -
PII: S1097-2765(01)00372-0
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11684018.pdf20 Apr 2002: Molecular Cell, Vol. 8, 829–839, October, 2001, Copyright 2001 by Cell Press. The Crystal Structure of the PX Domain from p40phoxBound to Phosphatidylinositol 3-Phosphate. Vam7 (Cheever et al., 2001), SNX3 (Xu et al., 2001b),and p40 phox -
The Structure of a Tunicate C-type Lectin from Polyandrocarpa…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10398588.pdf7 Jul 1999: Article No. jmbi.1999.2910 available online at http://www.idealibrary.com on J. Mol. Biol. (1999) 290, 867879. The Structure of a Tunicate C-type Lectin fromPolyandrocarpa misakiensis Complexed withD-Galactose. Se bastien F. Poget1, Glen B. Legge1, -
Catalytic Domain of Phosphoinositide-specificPhospholipase C…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9565585.pdf20 Apr 2002: Catalytic Domain of Phosphoinositide-specificPhospholipase C (PLC)MUTATIONAL ANALYSIS OF RESIDUES WITHIN THE ACTIVE SITE AND HYDROPHOBIC RIDGE OF PLCd1. (Received for publication, November 20, 1997, and in revised form, February 18, 1998). Moira V. -
doi:10.1016/j.devcel.2004.09.003
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15469844.pdf1 Nov 2004: Developmental Cell, Vol. 7, 559–569, October, 2004, Copyright 2004 by Cell Press. ESCRT-II, an Endosome-Associated Complex Requiredfor Protein Sorting: Crystal Structure andInteractions with ESCRT-III and Membranes. Ten of these proteins are -
x96255u149
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11090628.pdf20 Apr 2002: Molecular Cell, Vol. 6, 909–919, October, 2000, Copyright 2000 by Cell Press. Structural Determinants of Phosphoinositide3-Kinase Inhibition by Wortmannin, LY294002,Quercetin, Myricetin, and Staurosporine. for proteins such as protein kinase B -
Regulation of lipid binding underlies the activation mechanism of…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/22120714.pdf21 Nov 2012: Oncogene 31, 3655 (2012). doi:10.1038/onc.2011.532 -
©20 10 N atur e A mer ica, Inc. ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20081827.pdf2 Aug 2010: 20. 10 N. atur. e A. mer. ica,. Inc. All. righ. ts r. eser. ved. NATURE CHEMICAL BIOLOGY | VOL 6 | FEBRUARY 2010 | www.nature.com/naturechemicalbiology 1 1 7. ARTICLEPUBLISHED ONLINE: 10 JANUARY 2010 | DOI: 10.1038/NCHEMBIO.293. The PI(3)Ks are
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