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EHD Home Page: An ATPase involved in membrane remodelling
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/EHDs/index.html26 Sep 2011: What are EHDs and how does they work. These pages describe the structural and functional analysis of EHD2, carried out by Oli Daumke in the lab of Harvey McMahon. -
Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_0x62.html24 Aug 2021: b -. b_factor_distribution_graph() : cc-interface.hh. ... b_factor_from_map() : cc-interface.hh. -
Books - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/books/21 Jul 2023: Based on the series of B.B.C. Television Lectures of the same title. ... The impact of molecular biology on neuroscience’ by Francis Crick. Proceedings of the Royal Society Series B: Biological Sciences.
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Publications
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/publications/S., Cohen, F. E., DeArmond, S. J., Prusiner, S. B., and Safar, J. ... Sci. 26:337-339. Fons, R. D., Bogert, B. A., and Hegde, R. -
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https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/FtsA%20EMBO%20.pdf4 Oct 2000: 7# < , % A , ' ( % 0' 72# - = # ( % # < 6H , ' ( , = ( # < =$ $ , ' (# - ' ( / ' (# B = , ' ( 6H# - D / , 5 = / (, ' ( 6H % ( = ' (# B = %% ' ( / #. / B % , % ' (# , (- # / ' # - , $ G $ # - / , :B<- 0 442#. #. ... O # 049C2< , ' ( 1 # ) &. 33 498G44#. -
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https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10856244.pdf6 Jun 2000: D+ ,# D , # D!$+ /00A2 C <! 8! )'-'! 1:A:@1:0+. $ 3+ /00B2 3 , ) -. B?@B>1+. $ CR+ /002 8! )' '! ' ... 78! &< ,- '! %AB@%A+. 7+ D+ DG+ /00?2 6! /:52 8&-N39+ #! B>@B>0+. 8+=G+ /002 $# #! , #! /". "! R C1 ND6&N8 7) C! -
Publications
https://www2.mrc-lmb.cam.ac.uk/groups/ms/Publications.html15 Oct 2018: Nature Struct. Biol. 9:247-251. R.Bayliss, S.W.Leung, R.P.Baker, B.B.Quimby, A.H.Corbett & M.Stewart. ... M., Stewart A. G., Takeda A. A., Fontes M. R., Stewart M., Vértessy B. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/22
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/22JohnbrBased on the series of B.B.C. -
OUTLINE OF RESEARCH
https://www2.mrc-lmb.cam.ac.uk/groups/ms/Research.html15 Jan 2018: Except for mRNA, nuclear import and export are both mediated by soluble carrier molecules that are members of the importin-b superfamily. ... Biol. Chem. 277:50597-50606. R.Bayliss, S.W.Leung, R.P.Baker, B.B.Quimby, A.H.Corbett & M.Stewart. (2002). -
doi:10.1016/j.ceb.2004.06.009
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MillsMcMahonAp2Review.pdf23 Nov 2004: Current Opinion in Cell Biology. (a). (b). (c). (d). 380 Membranes and organelles. ... COP coat subcomplexesThere are seven COPI subunits (a, b, b’, d, g, e and z) divided into twosubcomplexes: the F subcomplex composed of b, d, g and z-COPs,of which -
Tutorial 3: Probability Theory,Random Variables andDistributions…
https://www2.mrc-lmb.cam.ac.uk/download/tutorial-3-probability-theory/?wpdmdl=18815&refresh=6682bd21cb80e171984412926 Mar 2014: AB – the union of A and B – all outcomes in A or B. • ... AB – A not B – all outcomes in A that are not in B. • -
THE JOURNAL OF BIOLOGICAL CHEMWXXY Vol. 265, No. 34, ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/2_Pewitt_EB_JBC_1990b.pdf29 Dec 2004: B. Forbush III (Yale University) and R. James Turner (National Institutes of Health). ... Protein Phosphorylation and Na/K/2Cl Cotransport 20749. 60 V. O0 b b 0 T. -
Tutorial 3: Probability Theory,Random Variables and Distributions –…
https://www2.mrc-lmb.cam.ac.uk/download/tutorial-3-probability-theory-random-variables-and-distributions-answers/?wpdmdl=18821&refresh=6682bd21e4b28171984412925 Mar 2014: 6. P (AB) = P (A) P (B) P (AB) = 1/4 6/13 3/26 = 31/52. ... P (B) =P (A) P (AB). P (A) 1. =0.4 0.80.4 1. -
PII: S0962-8924(99)01504-4
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/14_Hegde_RS_TCB_1999.pdf11 Mar 1999: orienting. N. NN. N. C. C. C. NN. (a) (b) (c)Ribosome. Translocon. ... Subdomain of ER. (c). EarlyLate. Never. a. b. (b). (a). FIGURE 2. -
Dlp Purification:
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/techniqs/Eva%20Methods.htm6 Feb 2008: Gex4T2. b-b-arrestin2-FL. pGex5.1. h-b-arrestin2 C1 (C-terminal tail fragment, 317–410). kind. pGex5.1. ... 1: 1 000. mono. b-adaptin 1,2. Sigma. 1:10 000. mono. b-arrestin1. -
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-json/wp/v2/pages/27
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-json/wp/v2/pages/27Biol. Cell,/em 18:3681-91./linliOng, H. L., Liu, X., Tsaneva-Atanasova, K., Singh, B. ... S./strong, Cohen, F. E., DeArmond, S. J., Prusiner, S. B., and Safar, J. -
doi:10.1016/j.cub.2004.09.077
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Snx1PeteCullen2004/Snx1PeteCullen2004.pdf23 Nov 2004: All rights reserved. DOI 10.1016/j. c u b. 2 0 0 4. ... 130, 765–771. 30. Kurten, R.C., Eddington, A.D., Chowdhury, P., Smith, R.D., Da-vidson, A.D., and Shank, B.B. -
Current Developments in Coot for Macromolecular Model Building…
https://www2.mrc-lmb.cam.ac.uk/coot/protein-science/Casanal_Lohkamp_Emsley_11112019-pe-2.pdf11 Nov 2019: The algorithm in action in Coot is illustrated inpanels (B), (C) and (D). ... printing of theplot, changing to Kleywegt plot (see B). (B) Kleywegt plot (Kleywegt 1996). -
doi:10.1016/j.biocel.2008.08.010
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cytomotive2008Lowe.pdf17 Sep 2008: B. B. B. B. B. B. B. B. B. B. C. ... arston AL, Errington J. Dynamic movement of the ParA-like Soj protein of B. -
Twinning and other pathologies Andrey Lebedev CCP4 OD-‐structures…
https://www2.mrc-lmb.cam.ac.uk/download/twinningaandaotherapathologiesa-andreyalebedeva-a/?wpdmdl=18788&refresh=6682bd1cd03b2171984412411 Jun 2013: P(Z). Z Z Z. a. a. b. b. b. c. c. ... The. (a) (b) (c) (d) (e). a. aaaa. b. b b b b. -
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https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Owen_EvansBAdap2000.pdf1 Aug 2000: 9 62 ( :1 $; ) :&1 $; ) :. $; )) ' ( 9 --./ --8+#9 ' <1=.1 $; $ &=>1 $; )? @. :11 ' $ ) #-8-# 62 ) ' ( ---# 9 $ ( ' ' # 62 4 A77 )( $ 7 ' )B # --&/ B( C' --8+ ... B( ;#R# A# D #C## R## ;9##C'2## #9# )--- 6 7 # 3 81&=8&#. -
Probability Theory Random Variables and Distributions Rob Nicholls…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_statistics_course_2014/lectures/Lecture3_Probability_Theory.pdf10 Mar 2014: Venn Diagram:. A B. B ={ four, five,six}. one. two, three six four five. ... Set Notation. Venn Diagram:. A B. A B ={two,three}. one. two, three six four five. -
The patterned assembly and stepwise Vps4-mediated disassembly of…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Hurtig%202023%20sciadv.ade5224.pdf16 Jul 2023: Email: andela.saric@ist.ac.at (A.Š.); r.vlijm@rug.nl (R.V.);bbaum@mrc-lmb.cam.ac.uk (B.B.). Hurtig et al., Sci. Adv. ... B) Quantification of preferred ESCRT-III homolog localization from imageslike those presented in (A). -
Probability Theory Random Variables and Distributions Rob Nicholls…
https://www2.mrc-lmb.cam.ac.uk/download/probability-theory-random-variables-and-distributions-rob-nicholls/?wpdmdl=18807&refresh=6682bd219876e171984412910 Mar 2014: Venn Diagram:. A B. B ={ four, five,six}. one. two, three six four five. ... Set Notation. Venn Diagram:. A B. A B ={two,three}. one. two, three six four five. -
The Coot User Manual
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/docs/coot.html1 Mar 2021: The Coot User Manual -
Articleshttps://doi.org/10.1038/s41594-019-0196-z 1MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Burmann%202019%20NSMB.pdf4 Mar 2019: b, Identification of the elbow. Long-distance cross-link midpoint density (see Fig. ... HeadN HeadCJointN JointCElbowN ElbowCHinge. Sm. c5–S. mc6. Sm. c–S. cpA. B. -
Refined Structure of (alpha)(beta)-Tubulin at 3.5 A Resolution
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/jmb%20tubulin%20refinement.pdf3 Nov 2001: interaction, in comparison with the longitudi-nal contact, has an important ionic contribution,both for a-a and b-b contacts. ... Lateral contacts. Lateral contacts between protolaments in thezinc sheets entail extensive interactions betweenhomologous -
Relocalization of STIM1 for Activation of Store-operated Ca2!Entry Is …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/47_Ong_HL_JBC_2007.pdf24 Sep 2015: Biol. Chem. 273, 19554–1955916. Liu, X., Singh, B. B., and Ambudkar, I. ... 93–10419. Singh, B. B., Liu, X., Tang, J., Zhu, M. X., and Ambudkar, I. -
S413_6a 39..44
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MreB%20Nature.pdf30 Aug 2001: b,. pH optimum. MreB was incubated under standard conditions (see Methods) with 100 mM. ... After washing with 5% buffer B the protein waseluted with 30% buffer B. -
Filament structure and subcellular organization of the bacterial…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Liu_PNAS_crescentin_2024.pdf28 Apr 2024: 3B). Dimer–dimer interactions between the two strands are primarily along the lateral direction, including type 4 (pair B- B’, antiparallel) and type 5 (pairs B- D’ and B’- D, parallel) ... D’. A-C or A’-C’. B-B’. D-B’ orD’-B. -
Asgard archaea shed light on the evolutionary origins of the…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Hatano%20Nat%20Comms%202022.pdf13 Jun 2022: 7A, B). Structuralmodels of these Heimdallarchaeotal proteins were generatedusing AlphaFold 274,75 (Supplementary Fig. ... Ubiquitin. I44V45. Heim Ubiquitin(model). (ii). (i). B. A CVPS28UEV. 469 aaSB SB. -
Descriptive and exploratory statistics
https://www2.mrc-lmb.cam.ac.uk/download/lecture-2-descriptive-statistics-and-exploratory-data-analysis/?wpdmdl=18806&refresh=6682bd214ca0c17198441293 Mar 2014: y-a)/(b-a) = 1-exp(-lambda x) y = b – (b-a) exp(-lambda x), if we see exponential function then we may have this particular relationship. ... y = a bx and a = 3, b=10. Conclusions. Average and variance are usual measures for location and spread of -
Four-stranded mini microtubules formed by Prosthecobacter BtubAB show …
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/PNAS-2017-Deng-E5950-8.pdf29 Dec 2017: Along three proto-filament interfaces, lateral contacts form a B-lattice with A-Aand B-B contacts (Fig. ... The view shown highlights theseam (A lattice, A-B lateral contacts). (B, Right) Rotated by 180, showing the B lattice (A-A and B-B lateral contacts -
Cryo‐EM structure of the full‐length Lon protease from Thermus…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Lon%20Coscia%202021%20FEBS.pdf14 Nov 2021: grids. The dark lines are the edges of GO flakes. (B) Representative 2D class averages. ... K33-linked polyubiquitin. Mol Cell 58, 95–109.22 Monika B-B, Martin TG, Naylor CE, Basak AK,. -
Basic principles of probability theory
https://www2.mrc-lmb.cam.ac.uk/download/lecture-6-linear-regression/?wpdmdl=18812&refresh=6682bd22b9a73171984413031 Mar 2014: y=f(x,b,e). ipipiii xxxy εβββ =. 2211. ipipiii. xxxy ebbb =. 2211. ... E(β̂)= β. E(. ˆ. b)=b. V(β̂)=σ 2(XTX)1. V(. ˆ. b)=s. 2. -
Scaling and Merging
https://www2.mrc-lmb.cam.ac.uk/download/diffraction-geometry-%e2%80%a2-diffraction-from-a-crystal-laue-equations-%e2%80%a2-reciprocal-lattice-%e2%80%a2-ewald-construction-%e2%80%a2-data/?wpdmdl=18795&refresh=6682bd1c19d0517198441247 May 2013: ruvw = u a v b w c where u, v, w are integers. ... b.b = 1 b.c = 0. c.c = 1 c.a = 0. -
15591370691369 1..30
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/elife_2019.pdf29 May 2019: B) GFP-PrP from wild type and DTMED10 cells was affinity purified under non-denaturing. ... B. B. B. Y B. BNb. APEX2. surface. Nb. total. lysate. -
early in DNA damage response and regulateRAP80 localization. Many ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MartensSytPap07.pdf16 Oct 2009: B. B. Zhou, S. J. Elledge, Nature 408, 433 (2000).2. J. ... 13, 2665 (2004).29. We thank B. Davletov for the provision of synaptotagmin. -
No Job Name
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/vandenent2008ftsq.pdf4 Mar 2008: The topology of thea-domain is b-a-a-b-b, where the third b-strand is packedin between the first and the second strands. ... coli FtsQ (green) on the b-domain of DivIB from G. stearothermophilus (blue). -
Molecular Cell, Vol. 2, 85–91, July, 1998, Copyright 1998 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/13_Hegde_RS_MolCell_1998.pdf16 Jul 1998: These membranes were then included during fully translocated into the lumen suggests that additionaltranslation reactions of prolactin (B), b-lactamase (C), wild-type PrP. ... Eachmembrane preparation was also included intranslation reactions of -
The Structure of a Tunicate C-type Lectin from Polyandrocarpa…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10398588.pdf7 Jul 1999: Acta Crystallog. sect. A, 47,110-119. Kastrup, J. S., Nielsen, B. B., Rasmussen, H., Holtet,T. ... Nielsen, B. B., Kastrup, J. S., Rasmussen, H., Holtet,T. L., Graversen, J. -
GB-9-7-229-Amos_9.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/gb-2008-9-7-229.pdf4 Aug 2008: The A-tubuleand B-tubule [73] can be distinguished even after the loss of accessory structures. ... 2 nm10 nmA. A B. B. AA B. B. AA BB. -
Mechanism of signal sequence handover from NAC to SRP on ribosomes…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/Science_2022.pdf27 Feb 2022: Boxed region indicates the closeup shownin (B). (B) Ribosome tunnel exit regions depicting the SRP54 NG and Mdomains, the NACa UBA domain, and the NACb anchor domain are colored slate,cyan, ... 2018).8. B. Wiedmann, H. Sakai, T. A. Davis, M. Wiedmann, -
The structure of bactofilin filaments reveals their mode of membrane…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Deng2019Natmicro.pdf26 Aug 2019: a b c. d e f. g h. i. 200 nm crossover distance. ... b, Evolutionary coupling scores calculated for an alignment of 12,646 bactofilin sequences. -
IntroductionThe endosomal system functions as an internal…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/SNX2Cullen2005.pdf17 Jan 2006: 5A,B). Furthermore,there was a clear enrichment of endogenous SNX2 on SNX1. ... J. Cell Sci. 115, 3889-3900. Carlton, J. G., Bujny, M. V., Peter, B. -
FtsA forms actin-like protofilaments
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/EMBO2012FtsAPiotr/emboj201276a.pdf27 Mar 2012: Periplasm. FtsAfilaments. 50 nm. A B EcFtsA 1– 405 TmFtsA. BsFtsABsFtsA 1– 425. ... see also Figure 3A and B). (B) Both the 1C subdomainof FtsA and the 1B subdomain of MreB consist of an a-alpha helix and a three-stranded b-sheet, but -
Structural Mapping of the Catalytic Mechanism for a…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9048554.pdf20 Apr 2002: a For each enzyme/ligand distance closer than 3.5 Å, the values aregiven for PLC-δ1 monomers A and B.b Included as putative long-range salt bridge with ... IP3/Ca2+ complex in PLC-δ1 monomer B moleculecontoured at 0.15 e/Å3. -
Twinning and other pathologies Andrey Lebedev CCP4 OD-‐structures…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_crystallography_course_2013/lectures/pathologies_and_twinning.pdf11 Jun 2013: P(Z). Z Z Z. a. a. b. b. b. c. c. ... The. (a) (b) (c) (d) (e). a. aaaa. b. b b b b. -
doi:10.1016/j.str.2008.06.010
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/18786397.pdf3 Sep 2008: layers, an A layer and a B layer. Within the A layer, successive. ... eration above positions A and B are labeled as A1. and B1, respectively. -
Journal of Lipid Research Volume 39, 1998 1287 Translocational ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/10_Rusinol_AE_JLR_1998.pdf30 May 1998: B) Phospholipid content (nmol/mg membrane protein) of control and PMME-enriched microsomes. ... 2. Pullinger, C. R., J. D. North, B. B. Teng, V.
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