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30 Apr 2024: Our plan is to publish research papers with new information on which human diseases involve programmed axon death and which specific people are most at risk. ... Individual people in families known to be at risk will also be able to determine their

30 Apr 2024: We're working on a project that studies diseases that affect the entire nervous system, just like they would in people. ... This will help us get reliable data that can be used to develop and improve treatments for nerve diseases in people.

30 Apr 2024: Where possible in our design we blind people to genotype/treatment groups with different people doing infections or analysis. ... We will discuss any advances with the relevant people at our establishment and implement them accordingly.

30 Apr 2024: The World Health Organisation estimates that worldwide, 301 million people live with anxiety, 280 million people live with depression, and 326 million people experience post-traumatic stress disorder. ... benefit people living with mental health

29 Apr 2024: It affects about 1 in 400 people in the UK. Crohn's disease affects about 1 in 700 people in the UK. ... In the shorter-term this will involve making new discoveries on the types and behaviour of common gut bacteria found in people and how these interact

29 Apr 2024: As a result, while it is not possible at this stage to provide a meaningful estimate of the total number of people this technology would benefit it is clear that the

30 Apr 2024: Why is it important to undertake this work? It is now predicted that 1 in 2 people will develop cancer in their lifetime and despite advances with new treatments they do ... We subscribe to the NC3Rs email updates and also receive regular updates from

30 Apr 2024: benefit people living with mental health disorders through the development of new treatments. ... In the longer term, understanding the risk factors that predict whether individuals are more vulnerable to developing mental health disorders may allow

30 Apr 2024: Downloaded: 9:21pm, 25 Apr 2024 Page 3 of 10. Dementias are the biggest health challenge of our generation; one in three people born today will develop the disease. ... With one million people in the UK predicted to have dementia by 2025 and the current

30 Apr 2024: Cancer, cardiovascular disease, diabetes and chronic respiratory diseases killed approximately 33.2 million people worldwide in 2019, a 28% increase compared to 2000. ... In the medium term this will allow us to choose the best designs or methods to take

29 Apr 2024: Why is it important to undertake this work? Despite decades of research, millions of people live with serious immune mediated disease such as colitis, arthritis, systemic lupus erythematosus (SLE) and atopic ... dermatitis. For example rheumatoid

29 Apr 2024: Each client is developing drugs which will hopefully contribute to helping people with various diseases with an unmet clinical need. ... For example, we have a large program of work studying haemophilia, a rare (1 in 30,000 people) but life-changing

30 Apr 2024: There are currently 6,079 people waiting for a transplant in the UK and many more who are not on the waiting list would benefit from having a diseased or damaged

30 Apr 2024: The most common form of arthritis, osteoarthritis (OA) is believed to affect an estimated 8 million people in the UK, and worldwide this figure rises to 343 million. ... OA is associated with age but younger people are also affected, often impacting on

30 Apr 2024: For example, Angelman syndrome, an imprinting disorder leading to severe intellectual disability affects 1 in 12,000-1 in 20,000 people worldwide, and Prader-Willi syndrome, another imprinting disorder linked ... to intellectual disability, compulsive

30 Apr 2024: With increased population lifespan, the incidence of people experiencing these devastating disorders will continue to rise. ... Our work has the potential to impact millions of people worldwide both at the social and economic levels.

30 Apr 2024: Currently, there are 1.4 million people that are living with acquired brain injuries and 40,000 deaths only from stroke annually in the UK, and an estimated 69 million people

30 Apr 2024: Where possible in our design we blind people to genotype/treatment groups with different people doing infections or analysis. ... We will discuss any advances with the relevant people at our establishment and implement them accordingly.

30 Apr 2024: Whipworms infect 500 million people worldwide, particularly affecting children 5-15 years of age. ... Hookworms infect 450 million people around the globe, and can cause iron deficiency anaemia, especially in high-risk populations (children and women of

29 Apr 2024: Furthermore, to determine whether inhibition of the activities of these proteins will be effective in the treatment of people with cancer. ... Downloaded: 9:12pm, 25 Apr 2024 Page 6 of 11. Some mice can experience weight loss due to the effects of the

30 Apr 2024: In the UK, the number of people with dementia is estimated to exceed one million in 2025 (National Health Service - Dementia guide). ... memory in disorders such as dementia and dyslexia which significant number of people are suffering from.

30 Apr 2024: Finding treatments for all aspects of patient care therefore is crucial to improve outcomes for people affected. ... All clients that we work with are developing test agents which will hopefully contribute to helping people with various bleeding disorders

29 Apr 2024: treat people after they have contracted a disease. ... Future pandemics are inevitable as the global population expands - our vaccines aim to reduce the risk of such pandemics happening again, by protecting people through vaccination, against viruses of

30 Apr 2024: They can cause significant burden to the patient, their families, and society as a whole; 14% of the social care budget in England is spent on people living with neurological conditions, ... Conditions involving neurodegeneration (when brain cells are

30 Apr 2024: However, although many more people now survive, e.g., heart attacks and stroke, the debilitating consequences on quality of life and high risk of a secondary event leads to a huge

29 Apr 2024: This will be useful in identifying people at risk of ill health from poor conditions during pregnancy and early life. ... For example, our results will help people who work in health care to provide more specialised lifestyle advice and improve pregnancy

30 Apr 2024: It also allows several people to work in parallel in different tissues such as bone marrow and blood that need to be handled fresh, thereby maximising the data obtained from single

30 Apr 2024: The clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various metabolic and cardiovascular diseases where current treatments are not ... The average age of people with NASH

30 Apr 2024: The Asthma and Lung UK estimates that approximately 12.7 million people in the UK have a history of longstanding respiratory illness including lung cancer and pulmonary fibrosis (scarring of the ... This will allow people to learn about novel aspects of

30 Apr 2024: In January 2020, there were 6183 people in the UK currently waiting for an organ transplant.

30 Apr 2024: Huntington’s disease is a rare genetic neurodegenerative disorder affecting approximately 2.71 people per 100,000 worldwide.

30 Apr 2024: In the UK in 2016-2018, almost half of deaths from breast cancer (48%) were in people aged 75 and over (Cancer Research UK website). ... people with TNBC.

30 Apr 2024: therapies that will directly benefit people. ... People with MS, in particular, will benefit from this research by the potential provision of cheap and safe drugs to promote remyelination and prevent progressive disability.

30 Apr 2024: The burden of disease is substantial, with more than 164 million people in the EU alone suffering from these diseases.

30 Apr 2024: We will also aim to ensure that people working under this license are subscribed to the 3Rs newsletter from the National Centre for the 3Rs (NC3Rs).

30 Apr 2024: All clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various diseases where current treatments are not available or need

30 Apr 2024: This will allow people to learn about novel aspects of cancer, ageing and new therapies, and will provide the opportunity for a productive exchange of ideas between the public, patients and

30 Apr 2024: These disruptions combine to produce symptoms which are only successfully treated by current therapies in some people but not others.