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30 Apr 2024: Cancer, cardiovascular disease, diabetes and chronic respiratory diseases killed approximately 33.2 million people worldwide in 2019, a 28% increase compared to 2000. ... In the medium term this will allow us to choose the best designs or methods to take

29 Apr 2024: Why is it important to undertake this work? Despite decades of research, millions of people live with serious immune mediated disease such as colitis, arthritis, systemic lupus erythematosus (SLE) and atopic ... dermatitis. For example rheumatoid

29 Apr 2024: Each client is developing drugs which will hopefully contribute to helping people with various diseases with an unmet clinical need. ... For example, we have a large program of work studying haemophilia, a rare (1 in 30,000 people) but life-changing

30 Apr 2024: There are currently 6,079 people waiting for a transplant in the UK and many more who are not on the waiting list would benefit from having a diseased or damaged

30 Apr 2024: The most common form of arthritis, osteoarthritis (OA) is believed to affect an estimated 8 million people in the UK, and worldwide this figure rises to 343 million. ... OA is associated with age but younger people are also affected, often impacting on

19 Aug 2021: womb. We hope to identify novel targets for drug intervention to protect people from developing cardiovascular diseases later in life.

30 Apr 2024: For example, Angelman syndrome, an imprinting disorder leading to severe intellectual disability affects 1 in 12,000-1 in 20,000 people worldwide, and Prader-Willi syndrome, another imprinting disorder linked ... to intellectual disability, compulsive

30 Apr 2024: With increased population lifespan, the incidence of people experiencing these devastating disorders will continue to rise. ... Our work has the potential to impact millions of people worldwide both at the social and economic levels.

30 Apr 2024: Currently, there are 1.4 million people that are living with acquired brain injuries and 40,000 deaths only from stroke annually in the UK, and an estimated 69 million people

30 Apr 2024: Where possible in our design we blind people to genotype/treatment groups with different people doing infections or analysis. ... We will discuss any advances with the relevant people at our establishment and implement them accordingly.

13 Sep 2021: Page 2 of 5. Our research aims to understand how and why mental health disorders occur, and to develop new treatments for people suffering from these disorders.

30 Apr 2024: Whipworms infect 500 million people worldwide, particularly affecting children 5-15 years of age. ... Hookworms infect 450 million people around the globe, and can cause iron deficiency anaemia, especially in high-risk populations (children and women of

13 Sep 2021: Many people suffering from chronic pain are poorly treated by current medications, either due to a lack of efficacy (the drugs do not work), or due to intolerable side effects.

13 Sep 2021: Why is it important to undertake this work? Currently around 1 in 2 people will develop cancer in their lifetime. ... In the shorter-term this will involve making new discoveries on the types and behaviour of common gut bacteria found in people and how

13 Sep 2021: tumours). How are these learning outcomes important to the people on the course?

29 Apr 2024: Furthermore, to determine whether inhibition of the activities of these proteins will be effective in the treatment of people with cancer. ... Downloaded: 9:12pm, 25 Apr 2024 Page 6 of 11. Some mice can experience weight loss due to the effects of the

30 Apr 2024: In the UK, the number of people with dementia is estimated to exceed one million in 2025 (National Health Service - Dementia guide). ... memory in disorders such as dementia and dyslexia which significant number of people are suffering from.

20 Aug 2021: This will help prevent people from getting kidney failure and make kidney transplants last longer, with important benefits; dialysis accounts for 2% of total NHS spending and transplantation restores patient independence

19 Aug 2021: Therefore, by testing different vaccines in mice with human immune systems we can identify better vaccines that are much more likely to work in people. ... Vaccine candidates that offer improved protection against malaria. A second generation Covid 19

30 Apr 2024: Finding treatments for all aspects of patient care therefore is crucial to improve outcomes for people affected. ... All clients that we work with are developing test agents which will hopefully contribute to helping people with various bleeding disorders

19 Aug 2021: In January 2020, there were 6183 people in the UK currently waiting for an organ transplant, an increase in more than 1% on the previous year.

3 Mar 2021: the University of Cambridge. The aim of this induction document is to introduce AWERB members and lay people, scientists especially. ... to maintain their expertise. The role may be undertaken by a single person or by a number of people at a.

18 Jun 2021: For example, the Sugen-hypoxia protocol in rats, representing the combination of a drug (Sugen) and low oxygen levels similar to those experienced by people at a high altitude (hypoxia), leads ... The human disease develops slowly and only affects about

29 Apr 2024: treat people after they have contracted a disease. ... Future pandemics are inevitable as the global population expands - our vaccines aim to reduce the risk of such pandemics happening again, by protecting people through vaccination, against viruses of

30 Apr 2024: However, although many more people now survive, e.g., heart attacks and stroke, the debilitating consequences on quality of life and high risk of a secondary event leads to a huge

30 Apr 2024: They can cause significant burden to the patient, their families, and society as a whole; 14% of the social care budget in England is spent on people living with neurological conditions, ... Conditions involving neurodegeneration (when brain cells are

18 Jun 2021: We are trying to understand the earliest processes that go wrong because revealing how they work may point to new therapeutic targets that delay disease onset so that people can lead ... Clumps of tau also cause other dementias, such as frontotemporal

13 Sep 2021: people per million. ... This "Pulmonary Arterial Hypertension" (PAH) is usually diagnosed in people between the ages of 20 and 60, affecting more women than men.

19 Aug 2021: Everyone working with animals will be supervised will be supervised and trained by experienced members of the lab, and when people with the required expertise are not available internally, we will

30 Apr 2024: It also allows several people to work in parallel in different tissues such as bone marrow and blood that need to be handled fresh, thereby maximising the data obtained from single

19 Aug 2021: Why is it important to undertake this work? As life expectancy increases, there are a growing number of brain diseases affecting people.

29 Apr 2024: This will be useful in identifying people at risk of ill health from poor conditions during pregnancy and early life. ... For example, our results will help people who work in health care to provide more specialised lifestyle advice and improve pregnancy

13 Sep 2021: research, approaches and techniques regularly with scientists, animal technicians and Named People (in particular Animal Care and Welfare Officers and Veterinary Surgeons) within and outside the institute.

13 Sep 2021: Starting in adolescence, people with mutations in their FBXO7 gene develop a progressive parkinsonism which affects their coordination along with other symptoms.

30 Apr 2024: In January 2020, there were 6183 people in the UK currently waiting for an organ transplant.

30 Apr 2024: The clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various metabolic and cardiovascular diseases where current treatments are not ... The average age of people with NASH

20 Aug 2021: Who or what will benefit from these outputs, and how? Neurodegenerative disease affects millions of people and animals worldwide.

30 Apr 2024: The Asthma and Lung UK estimates that approximately 12.7 million people in the UK have a history of longstanding respiratory illness including lung cancer and pulmonary fibrosis (scarring of the ... This will allow people to learn about novel aspects of

30 Apr 2024: Huntington’s disease is a rare genetic neurodegenerative disorder affecting approximately 2.71 people per 100,000 worldwide.

15 Nov 2023: Concordat signatories are encouraged to develop policies and processes to support the provision of information to the media, and to ensure that key people in their organisations understand why this is ... Openness means providing information that allows

13 Sep 2021: There are around 7.6 million people living with heart and circulatory diseases in the UK.

30 Apr 2024: In the UK in 2016-2018, almost half of deaths from breast cancer (48%) were in people aged 75 and over (Cancer Research UK website). ... people with TNBC.

19 Aug 2021: There are already approximately 50 million people worldwide with dementia, and as the general population ages, this has been predicted to increase to 150 million by 2050.

30 Apr 2024: The burden of disease is substantial, with more than 164 million people in the EU alone suffering from these diseases.

30 Apr 2024: therapies that will directly benefit people. ... People with MS, in particular, will benefit from this research by the potential provision of cheap and safe drugs to promote remyelination and prevent progressive disability.

30 Apr 2024: We will also aim to ensure that people working under this license are subscribed to the 3Rs newsletter from the National Centre for the 3Rs (NC3Rs).

18 Jun 2021: In addition, if we can develop new treatments for cancer, this will improve people's health-span: their length of healthy life. ... Of course, if people live into dependent old age this may increase societal costs later.

13 Sep 2021: Why is it important to undertake this work? Multiple sclerosis (MS) is a lifelong disease that affects the brain and spinal cord of people of all ages. ... This usually happens in people who are 50 and older. The progressive form of the disease is a

30 Apr 2024: All clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various diseases where current treatments are not available or need

13 Sep 2021: By studying early signs of the disease and developing preventative treatments for people at risk a real difference could be made to the prevalence of the disease and the suffering caused