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14 Aug 2023: GFP background. Aequorea victoria are brightly luminescent jellyfish, with glowing points around the margin of the umbrella. Light arises from yellow tissue masses that each consist of about 6000-7000 photogenic cells. The cytoplasm of these cells

14 Aug 2023: Maturation of green fluorescent protein. The post-translational maturation of GFP to the fluorescent form involves a number of steps. In the first step, the GFP apoprotein presumably must fold into a catalytically active conformation that

14 Aug 2023: Jim Haseloff. email: jh295(at)cam.ac.uk. Haseloff Lab. Department of Plant Sciences. University of Cambridge. Downing Street. Cambridge CB2 3EA. United Kingdom. tel: 44-1223-766546. swb: 44-1223-333900. web: http://haseloff.plantsci.cam.ac.uk.

14 Aug 2023: Manuel Waller, Eftychios Frangedakis, Alan O Marron, Susanna Sauret-Gueto, Jenna Rever, Cyrus Raja Rubenstein Sabbagh, Julian M Hibberd, Jim Haseloff, Karen Renzaglia, Péter Szövényi. Plant Journal, doi: 10.1111/tpj.16161. 2023. Land plants

14 Aug 2023: Research projects in the Haseloff Laboratory. Synthetic Biology is an emerging field that employs engineering principles to construct new genetic systems. The approach is based on the use of well characterised and reusable DNA components, and

14 Aug 2023: Part 1B Cellular & Developmental Biology. Plant Development. Prof. Jim Haseloff, University of Cambridge. Summary:. These four lectures cover some striking features of biological self-organisation and morphogenesis using examples from the model plant

14 Aug 2023: Cambridge-JIC teams in the international Genetically Engineered Machine (iGEM) competition. iGEM is an international undergraduate synthetic biology competition where student teams are given access to DNA parts from the Registry of Standard

14 Aug 2023: iGEM2010 project: E. glowli. The Cambridge iGEM2010 team worked on regeneration systems for bioluminescence and better, brighter light output, different coloured luciferases, instrumentation for quantitation and modelling the feasibility of using

14 Aug 2023: iGEM2009 project: E. chromi. The Cambridge iGEM2009 team created two kits of parts to facilitate the design and construction of biosensors in the the future. These complement genetically engineered bacterial biosensors that enable bacteria to

14 Aug 2023: iGEM2006 project: Self-organisation. Multicellular organisms undergo self-organisation during development. Our aim was to engineer self-organised pattern formation in free swimming bacteria cells by providing them with an artificial system allowing

14 Aug 2023: iGEM2007 project: Bacteria-On-Line. In order to engineer interesting and useful functions in biology, a robust and extensive range of intra- and inter-cellular signalling pathways must be available. By analogy with the Internet, where adoption of

14 Aug 2023: iGEM2005 project. The Cambridge iGEM2005 team explored a method to control chemotaxis using maltose regulation. The Cambridge iGEM2005 wiki is at:. Background information is at:. iGEM 2005 Students. James Brown: (Engineering, Cambridge) & PhD in

14 Aug 2023: The liverworts (or Marchantiophyta) are descendants of the earliest terrestrial plants. The group is characterised by morphological simplicity, and this is matched by simple underlying genome structures. Many lower plants, including liverworts,

14 Aug 2023: iGEM2011 project. Reflectins - iridescent proteins. The Cambridge iGEM2011 team worked with bionanophotonic systems - experimenting with the use of self-assembling protein structures from squid that produce striking iridescence in vivo. They

14 Aug 2023: NST PMS 1B: Supporting materials. Prof. Jim Haseloff (jh295@cam.ac.uk). Links to supplementary lecture materials below:. Click here to download a copy of the lecture notes and extended material as a PDF document.. (126MB, 38 pages). Lecture 1. Plant

14 Aug 2023: Marchantia polymorpha - a new model system for Synthetic Biology. The liverworts (or Marchantiophyta) are descendants of the earliest terrestrial plants. The group is characterised by morphological simplicity, and this seems to be matched by simple

14 Aug 2023: iGEM2008 project: iBrain. The Cambridge iGEM2008 team project aimed to set a foundation for future research in engineered multi-cellularity by pursuing electrical and peptide signalling, and cellular self-differentiation through spontaneous spatial

14 Aug 2023: The ß-glucuronidase (GUS) gene is used extensively as a reporter for gene expression in plants. Transformed tissues or patterns of gene expression can be identified histochemically, but this is generally a destructive test and is not suitable for

14 Aug 2023: Wellcome Image Awards 2011. Special Award. (http://images.wellcome.ac.uk/). Arabidopsis thaliana seedling. Fernan Federici and Lionel Dupuy. Wellcome Image Awards 2011. Award. (http://images.wellcome.ac.uk/). Ergot infected wheat flower. Fernan

14 Aug 2023: http://haseloff.plantsci.cam.ac.uk (note: these pages are suitable for direct printing) Jim Haseloff, University of Cambridge.