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  2. AWERB 3Rs Minutes 4th October 2024 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_041023_redacted.pdf
    14 May 2024: She met many other NIOs and was able make lots of new contacts and have discussions with people from other establishments such as heads of Governance, facility directors and companies that
  3. AOC Minutes 24th July 2020

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_24.07.20_redacted.pdf
    14 May 2024: There is a list of medical exemptions which apply but those people will be expected to keep a social distance of at least two metres.
  4. AWERB 3Rs Minutes 6th April 2022 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_060422_redacted.pdf
    14 May 2024: there will be an end to animal use in research anytime soon - has had a massive interest so far with over 200 people listening!
  5. AOC Minutes 23rd April 2021

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_23.04.21_redacted.pdf
    14 May 2024: They asked for researchers to engage more with the named people.
  6. AWERB 3Rs Minutes 2nd August 2023 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_020823_redacted.pdf
    14 May 2024: https://youtu.be/Q8A89PCP3iI For people with organ failure, transplantation is the only option.
  7. AOC Minutes 20th November 2020

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_20.11.20_redacted.pdf
    14 May 2024: It has been noted that some people are still wearing alternative RPE instead of FFP3 or powered respirators.
  8. AWERB 3Rs Minutes 4th May 2022 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_040522_redacted.pdf
    14 May 2024: Details of how was this possible? In section 2.9 further information about what database was used and can it be shared with other people?
  9. AOC Minutes 22nd May 2020

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_22.05.20_redacted.pdf
    14 May 2024: The NACWOs and facility managers are expected to provide advice to both researchers and UBS regarding the rate of people returning to their units.
  10. AOC Minutes 26th November 2021

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_26.11.21_redacted.pdf
    14 May 2024: Several people have attended the virtual LASA sessions. The online material is available until May.
  11. AOC Minutes 18th December 2020

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_18.12.20_redacted.pdf
    14 May 2024: There are current estimates that overall within UAS, particularly administrative support, there will be a 40% reduction in numbers of people coming in to the office at any one time to
  12. AOC Minutes 24th September 2021

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_24.09.21_redacted.pdf
    14 May 2024: asked for peoples comments on whether they want a party to go ahead or if staff would be happy with receiving vouchers again.
  13. 3Rs Minutes 2nd December 2020 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_021220_redacted.pdf
    14 May 2024: Finally, the committee felt that you should ask a lay-person to read your Non-Technical Summary to make sure your summary can be understand by people who do not have
  14. AWERB 3Rs Minutes 2nd August 2023 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_020823_redacted_0.pdf
    14 May 2024: https://youtu.be/Q8A89PCP3iI For people with organ failure, transplantation is the only option.
  15. AOC Minutes 24th June 2022

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_24.06.22_redacted.pdf
    14 May 2024: is going to the to talk to people who are interested in the work and to describe what is actually involved in the job.
  16. AOC Minutes 22nd September 2023

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_220923_redacted.pdf
    14 May 2024: It was agreed that the named people could come up with a list for.
  17. AOC Minutes 24th April 2020

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_24.04.20_redacted.pdf
    14 May 2024: is closed. People are also assuming parking outside the is free.
  18. AOC Minutes 25th November 2022

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_251122_redacted_0.pdf
    14 May 2024: This has been agreed. The new RCA reporting email address has been circulated this needs to be used from now on so the correct people are receiving the information.
  19. Axon degeneration and repair (non-technical summary)

    https://www.ubs.admin.cam.ac.uk/system/files/public/axon_degeneration_and_repair_non-technical_summary_redacted.pdf
    30 Apr 2024: Our plan is to publish research papers with new information on which human diseases involve programmed axon death and which specific people are most at risk. ... Individual people in families known to be at risk will also be able to determine their
  20. Exploring Bioelectronic Approaches to Nervous System Restoration in…

    https://www.ubs.admin.cam.ac.uk/system/files/public/exploring_bioelectronic_approaches_to_nervous_system_restoration_in_large_animals_non-technical_sum_redacted.pdf
    30 Apr 2024: We're working on a project that studies diseases that affect the entire nervous system, just like they would in people. ... This will help us get reliable data that can be used to develop and improve treatments for nerve diseases in people.
  21. Understanding Infection Pathogenesis to Guide Therapies…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf
    30 Apr 2024: Where possible in our design we blind people to genotype/treatment groups with different people doing infections or analysis. ... We will discuss any advances with the relevant people at our establishment and implement them accordingly.
  22. Neurobehavioural Mechanisms Underlying Mood, Anxiety and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_anxiety_and_stress-related_mental_health_disorders_non_redacted.pdf
    30 Apr 2024: The World Health Organisation estimates that worldwide, 301 million people live with anxiety, 280 million people live with depression, and 326 million people experience post-traumatic stress disorder. ... benefit people living with mental health
  23. Cartilage repair and replacement

    https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf
    29 Apr 2024: As a result, while it is not possible at this stage to provide a meaningful estimate of the total number of people this technology would benefit it is clear that the
  24. Development of Live Bacterial Therapeutics to treat diseases with…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_live_bacterial_therapeutics_to_treat_diseases_with_intestinal_dysbiosis_non-technica_redacted.pdf
    29 Apr 2024: It affects about 1 in 400 people in the UK. Crohn's disease affects about 1 in 700 people in the UK. ... In the shorter-term this will involve making new discoveries on the types and behaviour of common gut bacteria found in people and how these interact
  25. Interaction between the immune system and tumours (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/interaction_between_the_immune_system_and_tumours_non-technical_summary_redacted.pdf
    30 Apr 2024: Why is it important to undertake this work? It is now predicted that 1 in 2 people will develop cancer in their lifetime and despite advances with new treatments they do ... We subscribe to the NC3Rs email updates and also receive regular updates from
  26. Proteotoxicity in development and ageing (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/proteotoxicity_in_development_and_ageing_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:21pm, 25 Apr 2024 Page 3 of 10. Dementias are the biggest health challenge of our generation; one in three people born today will develop the disease. ... With one million people in the UK predicted to have dementia by 2025 and the current
  27. Neurobehavioural Mechanisms Underlying Mood, Impulsive and Compulsive …

    https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_impulsive_and_compulsive_mental_health_disorders_non-t_redacted.pdf
    30 Apr 2024: benefit people living with mental health disorders through the development of new treatments. ... In the longer term, understanding the risk factors that predict whether individuals are more vulnerable to developing mental health disorders may allow
  28. The development of in vivo expressed biologics as a platform for…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf
    30 Apr 2024: Cancer, cardiovascular disease, diabetes and chronic respiratory diseases killed approximately 33.2 million people worldwide in 2019, a 28% increase compared to 2000. ... In the medium term this will allow us to choose the best designs or methods to take
  29. Discovery and development of treatments for immunological diseases

    https://www.ubs.admin.cam.ac.uk/system/files/public/discovery_and_development_of_treatments_for_immunological_diseases_non-technical_summary_redacted.pdf
    29 Apr 2024: Why is it important to undertake this work? Despite decades of research, millions of people live with serious immune mediated disease such as colitis, arthritis, systemic lupus erythematosus (SLE) and atopic ... dermatitis. For example rheumatoid
  30. Breeding and maintenance of rodents for drug discovery platform

    https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_and_maintenance_of_rodents_for_drug_discovery_platform_non-technical_summary_redacted.pdf
    29 Apr 2024: Each client is developing drugs which will hopefully contribute to helping people with various diseases with an unmet clinical need. ... For example, we have a large program of work studying haemophilia, a rare (1 in 30,000 people) but life-changing
  31. Implantation of seeded scaffolds for tissue!organ development…

    https://www.ubs.admin.cam.ac.uk/system/files/public/implantation_of_seeded_scaffolds_for_tissueorgan_development_non-technical_summary_redacted.pdf
    30 Apr 2024: There are currently 6,079 people waiting for a transplant in the UK and many more who are not on the waiting list would benefit from having a diseased or damaged
  32. Tissue response following synovial joint injury and potential for…

    https://www.ubs.admin.cam.ac.uk/system/files/public/tissue_response_following_synovial_joint_injury_and_potential_for_therapies_to_restore_joint_structu_redacted.pdf
    30 Apr 2024: The most common form of arthritis, osteoarthritis (OA) is believed to affect an estimated 8 million people in the UK, and worldwide this figure rises to 343 million. ... OA is associated with age but younger people are also affected, often impacting on
  33. Epigenetic inheritence and the control of developmental and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/epigenetic_inheritance_and_the_control_of_developmental_and_physiological_processes_non-technical_s_redacted.pdf
    30 Apr 2024: For example, Angelman syndrome, an imprinting disorder leading to severe intellectual disability affects 1 in 12,000-1 in 20,000 people worldwide, and Prader-Willi syndrome, another imprinting disorder linked ... to intellectual disability, compulsive
  34. Understanding the roles of autophagy and related pathways in…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_roles_of_autophagy_and_related_pathways_in_proteinopathies_non-technical_summary_redacted.pdf
    30 Apr 2024: With increased population lifespan, the incidence of people experiencing these devastating disorders will continue to rise. ... Our work has the potential to impact millions of people worldwide both at the social and economic levels.
  35. Mouse developmental genetics to study neurodevelopment and disease…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mouse_developmental_genetics_to_study_neurodevelopment_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: Currently, there are 1.4 million people that are living with acquired brain injuries and 40,000 deaths only from stroke annually in the UK, and an estimated 69 million people
  36. Genes and environment at the interface of inflammation, immunity and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/genes_and_environment_at_the_interface_of_inflammation_immunity_and_metabolism_non-technical_summa_redacted.pdf
    30 Apr 2024: Where possible in our design we blind people to genotype/treatment groups with different people doing infections or analysis. ... We will discuss any advances with the relevant people at our establishment and implement them accordingly.
  37. Investigating the niche of mucosal parasitic nematodes and their…

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_niche_of_mucosal_parasitic_nematodes_and_their_interactions_with_their_hosts_non_redacted.pdf
    30 Apr 2024: Whipworms infect 500 million people worldwide, particularly affecting children 5-15 years of age. ... Hookworms infect 450 million people around the globe, and can cause iron deficiency anaemia, especially in high-risk populations (children and women of
  38. Determining mechanisms of tumour development and relapse following…

    https://www.ubs.admin.cam.ac.uk/system/files/public/determining_mechanisms_of_tumour_development_and_relapse_following_treatment_non-technical_summary_redacted.pdf
    29 Apr 2024: Furthermore, to determine whether inhibition of the activities of these proteins will be effective in the treatment of people with cancer. ... Downloaded: 9:12pm, 25 Apr 2024 Page 6 of 11. Some mice can experience weight loss due to the effects of the
  39. Neuronal circuit mechanisms underlying cognitive memory judgements…

    https://www.ubs.admin.cam.ac.uk/system/files/public/neuronal_circuit_mechanisms_underlying_cognitive_memory_judgements_non-technical_summary_redacted.pdf
    30 Apr 2024: In the UK, the number of people with dementia is estimated to exceed one million in 2025 (National Health Service - Dementia guide). ... memory in disorders such as dementia and dyslexia which significant number of people are suffering from.
  40. Provision of an outsourced drug development platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_development_platform_for_the_treatment_of_bleeding_disorders_non-te_redacted.pdf
    30 Apr 2024: Finding treatments for all aspects of patient care therefore is crucial to improve outcomes for people affected. ... All clients that we work with are developing test agents which will hopefully contribute to helping people with various bleeding disorders
  41. Vaccine development and fundamental reseach on viruses of medical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/vaccine_development_and_fundamental_research_on_viruses_of_medical_importance_non-technical_summary_redacted.pdf
    29 Apr 2024: treat people after they have contracted a disease. ... Future pandemics are inevitable as the global population expands - our vaccines aim to reduce the risk of such pandemics happening again, by protecting people through vaccination, against viruses of
  42. Understanding the cell biology behind cardiovascular diseases…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf
    30 Apr 2024: However, although many more people now survive, e.g., heart attacks and stroke, the debilitating consequences on quality of life and high risk of a secondary event leads to a huge
  43. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf
    30 Apr 2024: They can cause significant burden to the patient, their families, and society as a whole; 14% of the social care budget in England is spent on people living with neurological conditions, ... Conditions involving neurodegeneration (when brain cells are
  44. Platelets as a therapeutic tool

    https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf
    30 Apr 2024: It also allows several people to work in parallel in different tissues such as bone marrow and blood that need to be handled fresh, thereby maximising the data obtained from single
  45. Environmental and placental contributions to pregnancy and life-long…

    https://www.ubs.admin.cam.ac.uk/system/files/public/environmental_and_placental_contributions_to_pregnancy_and_life-long_health_non-technical_summary_redacted.pdf
    29 Apr 2024: This will be useful in identifying people at risk of ill health from poor conditions during pregnancy and early life. ... For example, our results will help people who work in health care to provide more specialised lifestyle advice and improve pregnancy
  46. Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …

    https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf
    30 Apr 2024: In January 2020, there were 6183 people in the UK currently waiting for an organ transplant.
  47. Provision of an outsourced drug discovery platform for metabolic and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_metabolic_and_cardiovascular_diseases_non-te_redacted.pdf
    30 Apr 2024: The clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various metabolic and cardiovascular diseases where current treatments are not ... The average age of people with NASH
  48. Remodelling of stem cells and niche cells from development and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/remodelling_of_stem_cells_and_niche_cells_from_development_and_regeneration_to_disease_non-technic_redacted.pdf
    30 Apr 2024: The Asthma and Lung UK estimates that approximately 12.7 million people in the UK have a history of longstanding respiratory illness including lung cancer and pulmonary fibrosis (scarring of the ... This will allow people to learn about novel aspects of
  49. The development of novel therapies (including cell and gene based…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf
    30 Apr 2024: Huntington’s disease is a rare genetic neurodegenerative disorder affecting approximately 2.71 people per 100,000 worldwide.
  50. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf
    30 Apr 2024: In the UK in 2016-2018, almost half of deaths from breast cancer (48%) were in people aged 75 and over (Cancer Research UK website). ... people with TNBC.
  51. Metabolic basis of microglia function in development (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf
    30 Apr 2024: The burden of disease is substantial, with more than 164 million people in the EU alone suffering from these diseases.

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