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  2. Genes and environment at the interface of inflammation, immunity and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/genes_and_environment_at_the_interface_of_inflammation_immunity_and_metabolism_non-technical_summa_redacted.pdf
    30 Apr 2024: Where possible in our design we blind people to genotype/treatment groups with different people doing infections or analysis. ... We will discuss any advances with the relevant people at our establishment and implement them accordingly.
  3. Investigating the niche of mucosal parasitic nematodes and their…

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_niche_of_mucosal_parasitic_nematodes_and_their_interactions_with_their_hosts_non_redacted.pdf
    30 Apr 2024: Whipworms infect 500 million people worldwide, particularly affecting children 5-15 years of age. ... Hookworms infect 450 million people around the globe, and can cause iron deficiency anaemia, especially in high-risk populations (children and women of
  4. Determining mechanisms of tumour development and relapse following…

    https://www.ubs.admin.cam.ac.uk/system/files/public/determining_mechanisms_of_tumour_development_and_relapse_following_treatment_non-technical_summary_redacted.pdf
    29 Apr 2024: Furthermore, to determine whether inhibition of the activities of these proteins will be effective in the treatment of people with cancer. ... Downloaded: 9:12pm, 25 Apr 2024 Page 6 of 11. Some mice can experience weight loss due to the effects of the
  5. Neuronal circuit mechanisms underlying cognitive memory judgements…

    https://www.ubs.admin.cam.ac.uk/system/files/public/neuronal_circuit_mechanisms_underlying_cognitive_memory_judgements_non-technical_summary_redacted.pdf
    30 Apr 2024: In the UK, the number of people with dementia is estimated to exceed one million in 2025 (National Health Service - Dementia guide). ... memory in disorders such as dementia and dyslexia which significant number of people are suffering from.
  6. Provision of an outsourced drug development platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_development_platform_for_the_treatment_of_bleeding_disorders_non-te_redacted.pdf
    30 Apr 2024: Finding treatments for all aspects of patient care therefore is crucial to improve outcomes for people affected. ... All clients that we work with are developing test agents which will hopefully contribute to helping people with various bleeding disorders
  7. Vaccine development and fundamental reseach on viruses of medical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/vaccine_development_and_fundamental_research_on_viruses_of_medical_importance_non-technical_summary_redacted.pdf
    29 Apr 2024: treat people after they have contracted a disease. ... Future pandemics are inevitable as the global population expands - our vaccines aim to reduce the risk of such pandemics happening again, by protecting people through vaccination, against viruses of
  8. Understanding the cell biology behind cardiovascular diseases…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf
    30 Apr 2024: However, although many more people now survive, e.g., heart attacks and stroke, the debilitating consequences on quality of life and high risk of a secondary event leads to a huge
  9. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf
    30 Apr 2024: They can cause significant burden to the patient, their families, and society as a whole; 14% of the social care budget in England is spent on people living with neurological conditions, ... Conditions involving neurodegeneration (when brain cells are
  10. Platelets as a therapeutic tool

    https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf
    30 Apr 2024: It also allows several people to work in parallel in different tissues such as bone marrow and blood that need to be handled fresh, thereby maximising the data obtained from single
  11. Environmental and placental contributions to pregnancy and life-long…

    https://www.ubs.admin.cam.ac.uk/system/files/public/environmental_and_placental_contributions_to_pregnancy_and_life-long_health_non-technical_summary_redacted.pdf
    29 Apr 2024: This will be useful in identifying people at risk of ill health from poor conditions during pregnancy and early life. ... For example, our results will help people who work in health care to provide more specialised lifestyle advice and improve pregnancy
  12. Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …

    https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf
    30 Apr 2024: In January 2020, there were 6183 people in the UK currently waiting for an organ transplant.
  13. Provision of an outsourced drug discovery platform for metabolic and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_metabolic_and_cardiovascular_diseases_non-te_redacted.pdf
    30 Apr 2024: The clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various metabolic and cardiovascular diseases where current treatments are not ... The average age of people with NASH
  14. Remodelling of stem cells and niche cells from development and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/remodelling_of_stem_cells_and_niche_cells_from_development_and_regeneration_to_disease_non-technic_redacted.pdf
    30 Apr 2024: The Asthma and Lung UK estimates that approximately 12.7 million people in the UK have a history of longstanding respiratory illness including lung cancer and pulmonary fibrosis (scarring of the ... This will allow people to learn about novel aspects of
  15. The development of novel therapies (including cell and gene based…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf
    30 Apr 2024: Huntington’s disease is a rare genetic neurodegenerative disorder affecting approximately 2.71 people per 100,000 worldwide.
  16. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf
    30 Apr 2024: In the UK in 2016-2018, almost half of deaths from breast cancer (48%) were in people aged 75 and over (Cancer Research UK website). ... people with TNBC.
  17. Metabolic basis of microglia function in development (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf
    30 Apr 2024: The burden of disease is substantial, with more than 164 million people in the EU alone suffering from these diseases.
  18. CNS Neuron-glia interactions, myelin plasticity, and regeneration, in …

    https://www.ubs.admin.cam.ac.uk/system/files/public/cns_neuron-glia_interactions_myelin_plasticity_and_regeneration_in_health_and_disease_non-techni_redacted.pdf
    30 Apr 2024: therapies that will directly benefit people. ... People with MS, in particular, will benefit from this research by the potential provision of cheap and safe drugs to promote remyelination and prevent progressive disability.
  19. Interventions in pregnancy effects of obesity on maternal and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/interventions_in_pregnancy_effects_of_obesity_on_maternal_and_offspring_health_non-technical_summa_redacted.pdf
    30 Apr 2024: We will also aim to ensure that people working under this license are subscribed to the 3Rs newsletter from the National Centre for the 3Rs (NC3Rs).
  20. Profiling of test agents in rodents in a drug discovery platform

    https://www.ubs.admin.cam.ac.uk/system/files/public/profiling_of_test_agents_in_rodents_in_a_drug_discovery_platform_non-technical_summary_redacted.pdf
    30 Apr 2024: All clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various diseases where current treatments are not available or need
  21. Cancer and its microenvironment! From mechanisms to translation…

    https://www.ubs.admin.cam.ac.uk/system/files/public/cancer_and_its_microenvironment_from_mechanisms_to_translation_non-technical_summary_redacted.pdf
    30 Apr 2024: This will allow people to learn about novel aspects of cancer, ageing and new therapies, and will provide the opportunity for a productive exchange of ideas between the public, patients and

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