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PPL number: | Granted: 09 Sep 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_live_bacterial_therapeutics_for_the_treatment_of_cancer_nts_redacted.pdf13 Sep 2021: Why is it important to undertake this work? Currently around 1 in 2 people will develop cancer in their lifetime. ... In the shorter-term this will involve making new discoveries on the types and behaviour of common gut bacteria found in people and how -
PPL number: | Granted: 20 Aug 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/training_in_advanced_or_complex_procedures_or_devices_nts_redacted.pdf13 Sep 2021: tumours). How are these learning outcomes important to the people on the course? -
Neuronal circuit mechanisms underlying cognitive memory judgements…
https://www.ubs.admin.cam.ac.uk/system/files/public/neuronal_circuit_mechanisms_underlying_cognitive_memory_judgements_non-technical_summary_redacted.pdf30 Apr 2024: In the UK, the number of people with dementia is estimated to exceed one million in 2025 (National Health Service - Dementia guide). ... memory in disorders such as dementia and dyslexia which significant number of people are suffering from. -
Determining mechanisms of tumour development and relapse following…
https://www.ubs.admin.cam.ac.uk/system/files/public/determining_mechanisms_of_tumour_development_and_relapse_following_treatment_non-technical_summary_redacted.pdf29 Apr 2024: Furthermore, to determine whether inhibition of the activities of these proteins will be effective in the treatment of people with cancer. ... Downloaded: 9:12pm, 25 Apr 2024 Page 6 of 11. Some mice can experience weight loss due to the effects of the -
PPL number: | Granted: 21 Aug 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_role_of_humoral_immunity_in_tissue-specific_immune_responses_in_health_and_disease_redacted.pdf20 Aug 2021: This will help prevent people from getting kidney failure and make kidney transplants last longer, with important benefits; dialysis accounts for 2% of total NHS spending and transplantation restores patient independence -
PPL number: | Granted: 11 Nov 20 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/mice_with_adaptive_human_immune_systems_and_their_application_for_drug_and_vaccine_discovery_nts_redacted.pdf19 Aug 2021: Therefore, by testing different vaccines in mice with human immune systems we can identify better vaccines that are much more likely to work in people. ... Vaccine candidates that offer improved protection against malaria. A second generation Covid 19 -
Provision of an outsourced drug development platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_development_platform_for_the_treatment_of_bleeding_disorders_non-te_redacted.pdf30 Apr 2024: Finding treatments for all aspects of patient care therefore is crucial to improve outcomes for people affected. ... All clients that we work with are developing test agents which will hopefully contribute to helping people with various bleeding disorders -
PPL number: | Granted: 26 Nov 20 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_nts_redacted.pdf19 Aug 2021: In January 2020, there were 6183 people in the UK currently waiting for an organ transplant, an increase in more than 1% on the previous year. -
University of Cambridge AWERB Handbook Version 6.6 2nd March ...
https://www.ubs.admin.cam.ac.uk/system/files/public/02.03.2021_awerb_handbook_6.6_external.pdf3 Mar 2021: the University of Cambridge. The aim of this induction document is to introduce AWERB members and lay people, scientists especially. ... to maintain their expertise. The role may be undertaken by a single person or by a number of people at a. -
PPL number: | Granted: 04 Mar 21 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_and_treatment_of_pulmonary_vascular_diseases_redacted.pdf18 Jun 2021: For example, the Sugen-hypoxia protocol in rats, representing the combination of a drug (Sugen) and low oxygen levels similar to those experienced by people at a high altitude (hypoxia), leads ... The human disease develops slowly and only affects about -
Vaccine development and fundamental reseach on viruses of medical…
https://www.ubs.admin.cam.ac.uk/system/files/public/vaccine_development_and_fundamental_research_on_viruses_of_medical_importance_non-technical_summary_redacted.pdf29 Apr 2024: treat people after they have contracted a disease. ... Future pandemics are inevitable as the global population expands - our vaccines aim to reduce the risk of such pandemics happening again, by protecting people through vaccination, against viruses of -
Understanding the cell biology behind cardiovascular diseases…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf30 Apr 2024: However, although many more people now survive, e.g., heart attacks and stroke, the debilitating consequences on quality of life and high risk of a secondary event leads to a huge -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf30 Apr 2024: They can cause significant burden to the patient, their families, and society as a whole; 14% of the social care budget in England is spent on people living with neurological conditions, ... Conditions involving neurodegeneration (when brain cells are -
PPL number: | Granted: 02 Feb 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/ageing_and_therapy_in_mouse_models_for_neurodegenerative_diseases_redacted_0.pdf18 Jun 2021: We are trying to understand the earliest processes that go wrong because revealing how they work may point to new therapeutic targets that delay disease onset so that people can lead ... Clumps of tau also cause other dementias, such as frontotemporal -
PPL number: | Granted: 09 Sep 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/the_integrated_stress_response_in_respiratory_disease_nts_redacted.pdf13 Sep 2021: people per million. ... This "Pulmonary Arterial Hypertension" (PAH) is usually diagnosed in people between the ages of 20 and 60, affecting more women than men. -
PPL number: | Granted: 24 Sep 20 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_role_of_physical_cues_in_nervous_system_function_in_wild_type_and_transgenic_anima_redacted.pdf19 Aug 2021: Everyone working with animals will be supervised will be supervised and trained by experienced members of the lab, and when people with the required expertise are not available internally, we will -
Platelets as a therapeutic tool
https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf30 Apr 2024: It also allows several people to work in parallel in different tissues such as bone marrow and blood that need to be handled fresh, thereby maximising the data obtained from single -
PPL number: | Granted: 13 Jan 20 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_and_genetic_regulation_of_glial_development_and_function_nts_redacted.pdf19 Aug 2021: Why is it important to undertake this work? As life expectancy increases, there are a growing number of brain diseases affecting people. -
Environmental and placental contributions to pregnancy and life-long…
https://www.ubs.admin.cam.ac.uk/system/files/public/environmental_and_placental_contributions_to_pregnancy_and_life-long_health_non-technical_summary_redacted.pdf29 Apr 2024: This will be useful in identifying people at risk of ill health from poor conditions during pregnancy and early life. ... For example, our results will help people who work in health care to provide more specialised lifestyle advice and improve pregnancy -
PPL number: | Granted: 30 Jun 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/genes_and_mechanisms_involved_in_genome_regulation_nts_redacted.pdf13 Sep 2021: research, approaches and techniques regularly with scientists, animal technicians and Named People (in particular Animal Care and Welfare Officers and Veterinary Surgeons) within and outside the institute. -
PPL number: | Granted: 25 Jun 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_pathobiology_and_therapeutic_opportunities_of_ubiquitin_ligases_nts_redacted.pdf13 Sep 2021: Starting in adolescence, people with mutations in their FBXO7 gene develop a progressive parkinsonism which affects their coordination along with other symptoms. -
Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …
https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf30 Apr 2024: In January 2020, there were 6183 people in the UK currently waiting for an organ transplant. -
Provision of an outsourced drug discovery platform for metabolic and…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_metabolic_and_cardiovascular_diseases_non-te_redacted.pdf30 Apr 2024: The clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various metabolic and cardiovascular diseases where current treatments are not ... The average age of people with NASH -
PPL number: | Granted: 19 Nov 19 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_of_transgenic_rodents_for_supply_of_tissues_to_the_client_nts_redacted.pdf20 Aug 2021: Who or what will benefit from these outputs, and how? Neurodegenerative disease affects millions of people and animals worldwide. -
Remodelling of stem cells and niche cells from development and…
https://www.ubs.admin.cam.ac.uk/system/files/public/remodelling_of_stem_cells_and_niche_cells_from_development_and_regeneration_to_disease_non-technic_redacted.pdf30 Apr 2024: The Asthma and Lung UK estimates that approximately 12.7 million people in the UK have a history of longstanding respiratory illness including lung cancer and pulmonary fibrosis (scarring of the ... This will allow people to learn about novel aspects of -
Concordat on Openness on Animal Research in the UKAnnual ...
https://www.ubs.admin.cam.ac.uk/sites/www.ubs.admin.cam.ac.uk/files/concordat-on-openness-annual-report-2023.pdf15 Nov 2023: Concordat signatories are encouraged to develop policies and processes to support the provision of information to the media, and to ensure that key people in their organisations understand why this is ... Openness means providing information that allows -
The development of novel therapies (including cell and gene based…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf30 Apr 2024: Huntington’s disease is a rare genetic neurodegenerative disorder affecting approximately 2.71 people per 100,000 worldwide. -
PPL number: | Granted: 06 Jul 21 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/the_role_of_the_immune_system_in_cardiovascular_disease_nts_expires2026_redacted.pdf13 Sep 2021: There are around 7.6 million people living with heart and circulatory diseases in the UK. -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf30 Apr 2024: In the UK in 2016-2018, almost half of deaths from breast cancer (48%) were in people aged 75 and over (Cancer Research UK website). ... people with TNBC. -
PPL number: | Granted: 12 Nov 20 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/discovery_of_novel_compounds_for_the_treatment_of_dementia._nts_redacted.pdf19 Aug 2021: There are already approximately 50 million people worldwide with dementia, and as the general population ages, this has been predicted to increase to 150 million by 2050. -
Metabolic basis of microglia function in development (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf30 Apr 2024: The burden of disease is substantial, with more than 164 million people in the EU alone suffering from these diseases. -
CNS Neuron-glia interactions, myelin plasticity, and regeneration, in …
https://www.ubs.admin.cam.ac.uk/system/files/public/cns_neuron-glia_interactions_myelin_plasticity_and_regeneration_in_health_and_disease_non-techni_redacted.pdf30 Apr 2024: therapies that will directly benefit people. ... People with MS, in particular, will benefit from this research by the potential provision of cheap and safe drugs to promote remyelination and prevent progressive disability. -
Interventions in pregnancy effects of obesity on maternal and…
https://www.ubs.admin.cam.ac.uk/system/files/public/interventions_in_pregnancy_effects_of_obesity_on_maternal_and_offspring_health_non-technical_summa_redacted.pdf30 Apr 2024: We will also aim to ensure that people working under this license are subscribed to the 3Rs newsletter from the National Centre for the 3Rs (NC3Rs). -
PPL number: | Granted: 08 Jul 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/regenerative_neuroimmunology_applied_to_progressive_multiple_sclerosis_research_nts_redacted.pdf13 Sep 2021: Why is it important to undertake this work? Multiple sclerosis (MS) is a lifelong disease that affects the brain and spinal cord of people of all ages. ... This usually happens in people who are 50 and older. The progressive form of the disease is a -
PPL number: | Granted: 10 May 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/defining_the_role_of_the_senescent_cells_upon_the_cancer_and_pre-malignant_microenvironment_redacted.pdf18 Jun 2021: In addition, if we can develop new treatments for cancer, this will improve people's health-span: their length of healthy life. ... Of course, if people live into dependent old age this may increase societal costs later. -
Profiling of test agents in rodents in a drug discovery platform
https://www.ubs.admin.cam.ac.uk/system/files/public/profiling_of_test_agents_in_rodents_in_a_drug_discovery_platform_non-technical_summary_redacted.pdf30 Apr 2024: All clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various diseases where current treatments are not available or need -
PPL number: | Granted: 10 Jun 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_diseases_with_an_inflammatory_component_nts_expires2022_redacted.pdf13 Sep 2021: By studying early signs of the disease and developing preventative treatments for people at risk a real difference could be made to the prevalence of the disease and the suffering caused -
PPL number: | Granted: 16 Jul 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/developing_therapeutic_drugs_for_cancer_including_the_establishment_of_tumour_models_nts_redacted.pdf13 Sep 2021: Why is it important to undertake this work? In 2018, over 17 million new cases of cancer were diagnosed worldwide, while 9.6 million people died from the disease. -
Cancer and its microenvironment! From mechanisms to translation…
https://www.ubs.admin.cam.ac.uk/system/files/public/cancer_and_its_microenvironment_from_mechanisms_to_translation_non-technical_summary_redacted.pdf30 Apr 2024: This will allow people to learn about novel aspects of cancer, ageing and new therapies, and will provide the opportunity for a productive exchange of ideas between the public, patients and -
Neural, physiological and behavioural mechanisms underlying cognition …
https://www.ubs.admin.cam.ac.uk/system/files/public/neural_physiological_and_behavioural_mechanisms_underlying_cognition_and_emotion_non-technical_sum_redacted.pdf30 Apr 2024: These disruptions combine to produce symptoms which are only successfully treated by current therapies in some people but not others. -
University of Cambridge Interim Review of the University of ...
https://www.ubs.admin.cam.ac.uk/sites/www.ubs.admin.cam.ac.uk/files/cambridge_review_final_draft_11.02.2017_redacted.pdf25 Jan 2022: people have been appointed, and are already making a difference. Recent initiatives such as PPL teams and the provision of surgery technicians are to be. -
PPL number: | Granted: 28 Jun 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/epithelial_stem_cell_behaviour_away_from_homeostasis_translational_relevance._nts_redacted.pdf13 Sep 2021: This will allow people to learn about novel aspects of regenerative medicine and early cancer, and will provide the opportunity for a productive exchange of ideas between patients and scientists. -
PPL number: | Granted: 30 Mar 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/investigation_of_normal_haematopoietic_stem_cell_subversion_and_the_evolution_maintenance_and_targeting_of_haematological_malignancies_redacted.pdf18 Jun 2021: Importantly, CH becomes increasingly common with age and is detected in more than 30% of people aged 70 years and older.
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