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Holliger Lab at the LMB
https://www2.mrc-lmb.cam.ac.uk/groups/ph1/people.html18 Mar 2022: PI. Postdoc, MRC CPE. PhD, ETH Zürich & MRC Centre for Protein Engineering (CPE). BSc, ETH Zürich. Maximillian Fürst - postdoc (EMBO long term fellowship), PhD, University of Groningen, MSc, LMU Munich, Research: Polymerase engineering, genetic -
Holliger Lab at the LMB
https://www2.mrc-lmb.cam.ac.uk/groups/ph1/18 Mar 2022: The work of our group is aimed at a better understanding of the fundamental principles and chemical logic that shape genetic systems and enable heredity and evolution, two of the defining hallmarks of life. Specifically, we ask how the capacity to -
Holliger Lab at the LMB
https://www2.mrc-lmb.cam.ac.uk/groups/ph1/ice.html18 Mar 2022: A crucial transition in the origin of life was the emergence of an informational polymer and its compartmentalization within protocellular structures. We are interested in the hypothesis that the physicochemical properties of water-ice, a simple -
Inter-institute Technician Symposium celebrates technical specialists …
https://www2.mrc-lmb.cam.ac.uk/inter-institute-technician-symposium-celebrates-technical-specialists/25 Oct 2022: The programme also included a speed networking session to allow people to mingle with technical specialists from other institutes and an interactive workshop by Kev House of Art of Brilliance. -
Holliger Lab at the LMB
https://www2.mrc-lmb.cam.ac.uk/groups/ph1/xna.html18 Mar 2022: Pinheiro et al (2012), Science, 336 , 341-344. DNA and its close relative RNA form the genetic material of all life on earth - the form the blueprint of every living organism. We asked the question if this function is unique or if alternative means -
Holliger Lab at the LMB
https://www2.mrc-lmb.cam.ac.uk/groups/ph1/research.html18 Mar 2022: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. -
Holliger Lab at the LMB
https://www2.mrc-lmb.cam.ac.uk/groups/ph1/rna_world.html18 Mar 2022: The molecular architecture of modern-day organisms is based on a division of labour among two types of biopolymers, proteins, which perform the bulk of molecular function and the nucleic acids DNA and RNA, which encode and carry genetic information. -
Holliger Lab at the LMB
https://www2.mrc-lmb.cam.ac.uk/groups/ph1/rna_self.html18 Mar 2022: As the ancestral replicase appears to be lost in time, work in our lab is aimed at building modern-day analogues of the ancestral replicase to reconstruct this key aspect of the RNA world and learn more about the functional properties of life’s -
Holliger Lab at the LMB
https://www2.mrc-lmb.cam.ac.uk/groups/ph1/patents.html18 Mar 2022: Method for Directed Evolution of DNA Enzymes / Compartmentalised Self Replication Method for in vitro Evolution of Molecular Libraries. International Application No. PCT/GB01/04108; 14 granted patents worldwide, Including EP1317539, EP1505151, and -
Holliger Lab at the LMB
https://www2.mrc-lmb.cam.ac.uk/groups/ph1/pubs.html18 Mar 2022: Houlihan G , Arangundy-Franklin S, Porebski BT, Subramanian N, Taylor AI & Holliger P. (2020) Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity. Nature Chemistry, 12 : 683–690 (cited by 17). Shows a method for
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