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  1. Results that match 1 of 2 words

  2. PPL number: | Granted: 26 Nov 20 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_nts_redacted.pdf
    19 Aug 2021: In January 2020, there were 6183 people in the UK currently waiting for an organ transplant, an increase in more than 1% on the previous year.
  3. University of Cambridge AWERB Handbook Version 6.6 2nd March ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/02.03.2021_awerb_handbook_6.6_external.pdf
    3 Mar 2021: the University of Cambridge. The aim of this induction document is to introduce AWERB members and lay people, scientists especially. ... to maintain their expertise. The role may be undertaken by a single person or by a number of people at a.
  4. PPL number: | Granted: 04 Mar 21 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_and_treatment_of_pulmonary_vascular_diseases_redacted.pdf
    18 Jun 2021: For example, the Sugen-hypoxia protocol in rats, representing the combination of a drug (Sugen) and low oxygen levels similar to those experienced by people at a high altitude (hypoxia), leads ... The human disease develops slowly and only affects about
  5. Vaccine development and fundamental reseach on viruses of medical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/vaccine_development_and_fundamental_research_on_viruses_of_medical_importance_non-technical_summary_redacted.pdf
    29 Apr 2024: treat people after they have contracted a disease. ... Future pandemics are inevitable as the global population expands - our vaccines aim to reduce the risk of such pandemics happening again, by protecting people through vaccination, against viruses of
  6. Understanding the cell biology behind cardiovascular diseases…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf
    30 Apr 2024: However, although many more people now survive, e.g., heart attacks and stroke, the debilitating consequences on quality of life and high risk of a secondary event leads to a huge
  7. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf
    30 Apr 2024: They can cause significant burden to the patient, their families, and society as a whole; 14% of the social care budget in England is spent on people living with neurological conditions, ... Conditions involving neurodegeneration (when brain cells are
  8. PPL number: | Granted: 02 Feb 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/ageing_and_therapy_in_mouse_models_for_neurodegenerative_diseases_redacted_0.pdf
    18 Jun 2021: We are trying to understand the earliest processes that go wrong because revealing how they work may point to new therapeutic targets that delay disease onset so that people can lead ... Clumps of tau also cause other dementias, such as frontotemporal
  9. PPL number: | Granted: 09 Sep 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_integrated_stress_response_in_respiratory_disease_nts_redacted.pdf
    13 Sep 2021: people per million. ... This "Pulmonary Arterial Hypertension" (PAH) is usually diagnosed in people between the ages of 20 and 60, affecting more women than men.
  10. PPL number: | Granted: 24 Sep 20 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_role_of_physical_cues_in_nervous_system_function_in_wild_type_and_transgenic_anima_redacted.pdf
    19 Aug 2021: Everyone working with animals will be supervised will be supervised and trained by experienced members of the lab, and when people with the required expertise are not available internally, we will
  11. Platelets as a therapeutic tool

    https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf
    30 Apr 2024: It also allows several people to work in parallel in different tissues such as bone marrow and blood that need to be handled fresh, thereby maximising the data obtained from single
  12. PPL number: | Granted: 13 Jan 20 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_and_genetic_regulation_of_glial_development_and_function_nts_redacted.pdf
    19 Aug 2021: Why is it important to undertake this work? As life expectancy increases, there are a growing number of brain diseases affecting people.
  13. Environmental and placental contributions to pregnancy and life-long…

    https://www.ubs.admin.cam.ac.uk/system/files/public/environmental_and_placental_contributions_to_pregnancy_and_life-long_health_non-technical_summary_redacted.pdf
    29 Apr 2024: This will be useful in identifying people at risk of ill health from poor conditions during pregnancy and early life. ... For example, our results will help people who work in health care to provide more specialised lifestyle advice and improve pregnancy
  14. PPL number: | Granted: 30 Jun 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/genes_and_mechanisms_involved_in_genome_regulation_nts_redacted.pdf
    13 Sep 2021: research, approaches and techniques regularly with scientists, animal technicians and Named People (in particular Animal Care and Welfare Officers and Veterinary Surgeons) within and outside the institute.
  15. PPL number: | Granted: 25 Jun 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_pathobiology_and_therapeutic_opportunities_of_ubiquitin_ligases_nts_redacted.pdf
    13 Sep 2021: Starting in adolescence, people with mutations in their FBXO7 gene develop a progressive parkinsonism which affects their coordination along with other symptoms.
  16. Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …

    https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf
    30 Apr 2024: In January 2020, there were 6183 people in the UK currently waiting for an organ transplant.
  17. Provision of an outsourced drug discovery platform for metabolic and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_metabolic_and_cardiovascular_diseases_non-te_redacted.pdf
    30 Apr 2024: The clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various metabolic and cardiovascular diseases where current treatments are not ... The average age of people with NASH
  18. PPL number: | Granted: 19 Nov 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_of_transgenic_rodents_for_supply_of_tissues_to_the_client_nts_redacted.pdf
    20 Aug 2021: Who or what will benefit from these outputs, and how? Neurodegenerative disease affects millions of people and animals worldwide.
  19. Remodelling of stem cells and niche cells from development and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/remodelling_of_stem_cells_and_niche_cells_from_development_and_regeneration_to_disease_non-technic_redacted.pdf
    30 Apr 2024: The Asthma and Lung UK estimates that approximately 12.7 million people in the UK have a history of longstanding respiratory illness including lung cancer and pulmonary fibrosis (scarring of the ... This will allow people to learn about novel aspects of
  20. The development of novel therapies (including cell and gene based…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf
    30 Apr 2024: Huntington’s disease is a rare genetic neurodegenerative disorder affecting approximately 2.71 people per 100,000 worldwide.
  21. Concordat on Openness on Animal Research in the UKAnnual ...

    https://www.ubs.admin.cam.ac.uk/sites/www.ubs.admin.cam.ac.uk/files/concordat-on-openness-annual-report-2023.pdf
    15 Nov 2023: Concordat signatories are encouraged to develop policies and processes to support the provision of information to the media, and to ensure that key people in their organisations understand why this is ... Openness means providing information that allows
  22. PPL number: | Granted: 06 Jul 21 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_role_of_the_immune_system_in_cardiovascular_disease_nts_expires2026_redacted.pdf
    13 Sep 2021: There are around 7.6 million people living with heart and circulatory diseases in the UK.
  23. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf
    30 Apr 2024: In the UK in 2016-2018, almost half of deaths from breast cancer (48%) were in people aged 75 and over (Cancer Research UK website). ... people with TNBC.
  24. PPL number: | Granted: 12 Nov 20 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/discovery_of_novel_compounds_for_the_treatment_of_dementia._nts_redacted.pdf
    19 Aug 2021: There are already approximately 50 million people worldwide with dementia, and as the general population ages, this has been predicted to increase to 150 million by 2050.
  25. Metabolic basis of microglia function in development (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf
    30 Apr 2024: The burden of disease is substantial, with more than 164 million people in the EU alone suffering from these diseases.
  26. CNS Neuron-glia interactions, myelin plasticity, and regeneration, in …

    https://www.ubs.admin.cam.ac.uk/system/files/public/cns_neuron-glia_interactions_myelin_plasticity_and_regeneration_in_health_and_disease_non-techni_redacted.pdf
    30 Apr 2024: therapies that will directly benefit people. ... People with MS, in particular, will benefit from this research by the potential provision of cheap and safe drugs to promote remyelination and prevent progressive disability.
  27. Interventions in pregnancy effects of obesity on maternal and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/interventions_in_pregnancy_effects_of_obesity_on_maternal_and_offspring_health_non-technical_summa_redacted.pdf
    30 Apr 2024: We will also aim to ensure that people working under this license are subscribed to the 3Rs newsletter from the National Centre for the 3Rs (NC3Rs).
  28. Profiling of test agents in rodents in a drug discovery platform

    https://www.ubs.admin.cam.ac.uk/system/files/public/profiling_of_test_agents_in_rodents_in_a_drug_discovery_platform_non-technical_summary_redacted.pdf
    30 Apr 2024: All clients that we work with are developing test agents (potential new drugs) which will hopefully contribute to helping people with various diseases where current treatments are not available or need
  29. PPL number: | Granted: 10 May 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/defining_the_role_of_the_senescent_cells_upon_the_cancer_and_pre-malignant_microenvironment_redacted.pdf
    18 Jun 2021: In addition, if we can develop new treatments for cancer, this will improve people's health-span: their length of healthy life. ... Of course, if people live into dependent old age this may increase societal costs later.
  30. PPL number: | Granted: 08 Jul 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/regenerative_neuroimmunology_applied_to_progressive_multiple_sclerosis_research_nts_redacted.pdf
    13 Sep 2021: Why is it important to undertake this work? Multiple sclerosis (MS) is a lifelong disease that affects the brain and spinal cord of people of all ages. ... This usually happens in people who are 50 and older. The progressive form of the disease is a
  31. PPL number: | Granted: 10 Jun 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_diseases_with_an_inflammatory_component_nts_expires2022_redacted.pdf
    13 Sep 2021: By studying early signs of the disease and developing preventative treatments for people at risk a real difference could be made to the prevalence of the disease and the suffering caused
  32. Cancer and its microenvironment! From mechanisms to translation…

    https://www.ubs.admin.cam.ac.uk/system/files/public/cancer_and_its_microenvironment_from_mechanisms_to_translation_non-technical_summary_redacted.pdf
    30 Apr 2024: This will allow people to learn about novel aspects of cancer, ageing and new therapies, and will provide the opportunity for a productive exchange of ideas between the public, patients and
  33. PPL number: | Granted: 16 Jul 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/developing_therapeutic_drugs_for_cancer_including_the_establishment_of_tumour_models_nts_redacted.pdf
    13 Sep 2021: Why is it important to undertake this work? In 2018, over 17 million new cases of cancer were diagnosed worldwide, while 9.6 million people died from the disease.
  34. Neural, physiological and behavioural mechanisms underlying cognition …

    https://www.ubs.admin.cam.ac.uk/system/files/public/neural_physiological_and_behavioural_mechanisms_underlying_cognition_and_emotion_non-technical_sum_redacted.pdf
    30 Apr 2024: These disruptions combine to produce symptoms which are only successfully treated by current therapies in some people but not others.
  35. University of Cambridge Interim Review of the University of ...

    https://www.ubs.admin.cam.ac.uk/sites/www.ubs.admin.cam.ac.uk/files/cambridge_review_final_draft_11.02.2017_redacted.pdf
    25 Jan 2022: people have been appointed, and are already making a difference.  Recent initiatives such as PPL teams and the provision of surgery technicians are to be.
  36. PPL number: | Granted: 28 Jun 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/epithelial_stem_cell_behaviour_away_from_homeostasis_translational_relevance._nts_redacted.pdf
    13 Sep 2021: This will allow people to learn about novel aspects of regenerative medicine and early cancer, and will provide the opportunity for a productive exchange of ideas between patients and scientists.
  37. PPL number: | Granted: 30 Mar 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigation_of_normal_haematopoietic_stem_cell_subversion_and_the_evolution_maintenance_and_targeting_of_haematological_malignancies_redacted.pdf
    18 Jun 2021: Importantly, CH becomes increasingly common with age and is detected in more than 30% of people aged 70 years and older.

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