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18 Dec 2018: first generation) and in vitro (second generation) methods of antibody discovery with novel in silico. ... Structure-based methods of antibody design. Structural modelling of antibodies. Structure-based methodsof antibody design (Fig.

17 Sep 2017: intrinsically disordered proteins’ are flexible in their shape and lack a stable three-dimensional. ... have suggested that the amino acid sequence of IDPs display a higher substitution.

6 Jun 2016: However, additional insight can be obtained by analyzing the amyloidogenic properties of β 2m in terms of sequence- and structure-based properties. ... The three structures display electron density of excellent quality along the polypeptide chains.

28 Nov 2015: These methods have beensuccessfully used to probe the unfolding transitions in severalsmall proteins and to structurally characterize low populatedprotein folding intermediates primarily based on the CPMGRD-derived chemical ... coli BL21(DE3) cells in H2O

22 Jul 2012: The method used for this purpose is called BATON, which is based on COM-PARER [23]. ... com-puting the entropic changes in free energy during flexible protein-ligand docking.

25 Jan 2007: 1977). All calculations. used an atom-based truncation scheme with a list cut-. ... which is known to be highly flexible (Tjandra et al. 1995; Wang et al.