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14 Jun 2006: Based on these cocrystal structures and a conserved. arylmorpholine pharmacophore model, structural models. ... These pioneering. studies were among the first to explore signaling by PI3-K.

15 May 2007: nitrocellulose membrane was first stained with ponceau red for quantification of GST fusion proteins. ... This hypothesis was. first verified in vitro by testing the AP-2-binding properties.

3 Sep 2008: First, the B molecules. from opposite strands contact each other at the center of the. ... The insets display schematic representations of. these interactions. (B) The intrastrand contacts between the a3/a4.

27 Apr 2009: Clathrin-independent endocy-tosis itself has been further dissected into seem-ingly distinct pathways, based on the reliance ofthese pathways on certain proteins and lipids,their differential drug sensitivities and theirabilities ... Eps15 appears to act

5 Jul 2010: The rings are composed ofglobularsubunits and their power spectra display weak eightfold com-ponents (results not shown). ... of the membrane borders produced by high salt or EDTA isassociated with the detachment of particles from around the.

14 Jul 2011: We produced a translation-competent fractionated RRL (Fr-RRL) (Supplementary Fig. 7) that selectively decreased the ubiquitina-tion of non-translocated PrP (Fig. ... To determine when the Bag6 complex first captures MLPs, we ana-lysed ribosome-nascent

11 Aug 2015: The cryo-EMreconstruction of this native complex provided the first structure of SRP bound to the ribosome ina ‘scanning’ mode. ... Integration of SRP recruitment with the translational elongation cycle. (A) Stalled RNCs were produced.

11 Aug 2015: First, the region around the ribosome exit tunnel is highly crowded when bound to the translocon (Pfeffer et al., 2014). ... A) Short RNCs containing the pPL or N7a signal peptides were produced in reactions containing or lacking RMs.

11 Nov 2019: first try to solve a structure with heavy atom derivatives if molecular replacement. ... or are more flexible than the majority of the structure). Interactive display of the.

25 Nov 2019: Fig. 2c and Extended Data Figs. 2 and 3). Based on biochemical analysis of stalling (Fig. ... When poly(A) first enters the A-site, it likely samples the helical state very rapidly.