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LMB 365 - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/news-and-events/lmb-365/21 Jul 2023: During the last year, over 4,500 initial crystallisation screens were used at the LMB to test macromolecular samples of interest. ... This image for day 263 of #LMB365 shows a test spectrum created using precision sensors and software. -
New insight into how membrane proteins are made - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/new-insight-into-how-membrane-proteins-are-made/9 Nov 2018: synthesised in a test tube. -
Discovering how translation and mRNA decay are linked - MRC…
https://www2.mrc-lmb.cam.ac.uk/discovering-how-translation-and-mrna-decay-are-linked/21 Jun 2018: They then added them all to a test tube where they assembled into the complete active complex. ... Michael was then able to study the activity and regulation of Ccr4-Not in this test tube set-up. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/22876
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/22876button" href="#howcan" style="color:#2e2d61;background-color:#ff9d1b"How can we test for, treat and prevent SARS-CoV-2 infection?/a/divn/divnnnnhr class="wp-block-separator has-css-opacity ... has-text-color has-background" id="howcan" -
Antiviral Bicycles are effective against SARS-CoV-2 - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/antiviral-bicycles-are-effective-against-sars-cov-2/16 Jun 2023: In order to turn the selected Bicycles into antivirals, Marina Vaysburd and Donna Mallery developed an assay to test for antiviral activity quickly and safely in the lab. -
New mechanism found that maintains intracellular water balance - MRC…
https://www2.mrc-lmb.cam.ac.uk/new-mechanism-found-that-maintains-intracellular-water-balance/18 Oct 2023: These concepts were tested using a broad range of experimental systems, including single proteins in a test tube, complex mixtures of biological molecules that exist within the cytoplasm, as well as -
Max Perutz Lecture to be given by John Diffley - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/max-perutz-lecture-to-be-given-by-john-diffley/20 Feb 2020: Recently they have developed a way of using these machines to copy DNA in a test tube, giving an unprecedented view of this fascinating and essential process. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/16810
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/16810More recently, Iu2019ve worked with Richard Henderson and Greg McMullan on various high vacuum test rigs for the new breed of digital EM (electron microscopy) detectors, which is really exciting because -
How replication of DNA is initiated at origins - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/how-replication-of-dna-is-initiated-at-origins/16 Nov 2018: By assembling the yeast DNA replication machinery at a replication origin in a test tube, starting from individual purified components, Valentina Aria, from Joseph Yeeles’ group, was able to investigate the -
LMB welcomes Emmanuel Derivery as new Group Leader - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/lmb-welcomes-emmanuel-derivery-new-group-leader/17 Nov 2016: Ultimately, my plan is to use flies as test tubes to increase our understanding of mammalian systems, potentially allowing restoration of asymmetric divisions in situations where it has been lost. -
A map to show the way to sense smell, temperature, and humidity - MRC …
https://www2.mrc-lmb.cam.ac.uk/a-map-to-show-the-way-to-sense-smell-temperature-and-humidity/23 Jul 2020: Producing maps of how these neurons connect with each other allows scientists to build and test theories to explain how complex behaviours can arise from electrochemical signalling across neural circuits. -
Uncovering the action of a selective holophosphatase inhibitor - MRC…
https://www2.mrc-lmb.cam.ac.uk/uncovering-action-selective-holophosphatase-inhibitor/31 Jul 2017: To test whether Guanabenz and Sephin1 cause R15A to change in shape, Marta measured the sensitivity of R15 to enzymes which can break it into pieces. -
Uncovering the molecular basis of triage during protein synthesis -…
https://www2.mrc-lmb.cam.ac.uk/uncovering-molecular-basis-triage-protein-synthesis/20 Jan 2017: To answer this question, Susan Shao, a former postdoc in Manu’s lab, worked with Monica Rodrigo-Brenni and Maryann Kivlen to biochemically rebuild this triage reaction in a test tube -
A new directed evolution technique to unlock the potential of XNAs -…
https://www2.mrc-lmb.cam.ac.uk/a-new-directed-evolution-technique-to-unlock-the-potential-of-xnas/20 Jul 2020: Alongside applications in research, this capacity is also used for medical tests, such as to test for the presence of viral RNA, including in COVID-19 tests. -
2021 Max Perutz Lecture to be given by David Baker - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/2021-max-perutz-lecture-to-be-given-by-david-baker/20 Apr 2021: SARS-COV2 provided a test of the relevance of these methods to real-world challenges. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/12947
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/12947Visitors could view u2018mini-brainsu2019 in a dish and find out how these brain organoids are used to study brain development, and then test their matching skills in the u2018Where is -
Christy Russell receives General Certificate in Occupational Health…
https://www2.mrc-lmb.cam.ac.uk/christy-russell-receives-general-certificate-in-occupational-health-and-safety/22 May 2024: That was hard work. Each evening, I was also completing test tasks in a similar format to the exam. -
Donald Caspar (1927 – 2021) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/donald-caspar-1927-2021/5 Jan 2022: single crystal virus diffraction patterns, which he had asserted could test his theory with Jim Watson that “spherical” viruses should have cubic symmetry (tetrahedral, octahedral or icosahedral). -
Testing the capacity for intracellular antibodies to neutralise…
https://www2.mrc-lmb.cam.ac.uk/testing-the-capacity-for-intracellular-antibodies-to-neutralise-sars-cov-2/29 Jul 2021: Further, standard tests that measure the activity of anti-S antibodies against the virus are unable to assess the virus-neutralising capacity of anti-N antibodies. ... Developing an assay to test for intracellular anti-viral activity of anti-N antibodies -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11827
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11827Visitors could view u2018mini-brainsu2019 in a dish and find out how these brain organoids are used to study brain development, and then test their matching skills in the u2018Where is -
Behind the Scenes with... Steve Scotcher - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/share-your-memories/steve-scotcher/31 Mar 2021: More recently, I’ve worked with Richard Henderson and Greg McMullan on various high vacuum test rigs for the new breed of digital EM (electron microscopy) detectors, which is really exciting -
The LMB welcomes Albert Cardona as a new Group Leader - MRC…
https://www2.mrc-lmb.cam.ac.uk/the-lmb-welcomes-albert-cardona-as-a-new-group-leader/2 Dec 2019: Albert’s group then plan to use this information to develop and experimentally test theoretical models that can explain the variety of animal behaviours elicited by different stimuli. -
Effects of caffeine on the human circadian clock - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/effects-of-caffeine-on-the-human-circadian-clock/17 Sep 2015: Trials are needed to test the latter, and it will be important to monitor for caffeine-induced sleep disruption under such conditions, which could worsen jet lag. -
A synthetic molecule that can restore lost connections in the brain - …
https://www2.mrc-lmb.cam.ac.uk/a-synthetic-molecule-that-can-restore-lost-connections-in-the-brain/28 Aug 2020: As well as observing reconnection of synapses, the team were able to measure improvements in behavioural tests, with restored motor coordination in cerebellar ataxia, better performance in memory tests in mouse -
Contents:
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/proshade/tutorial_proshade.html30 Jan 2019: The following screenshot shows the result for the test map EMD_1290.. -
STEM in Song - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/news-and-events/public-engagement/events-at-the-lmb/stem-in-song/21 Jul 2023: Visitors could view ‘mini-brains’ in a dish and find out how these brain organoids are used to study brain development, and then test their matching skills in the ‘Where is -
LMB Congratulates John Gurdon on Nobel Prize Announcement - MRC…
https://www2.mrc-lmb.cam.ac.uk/lmb-congratulates-john-gurdon-on-nobel-prize-announcement/8 Oct 2012: While here he continued to develop the use of Xenopus oocytes as a living test tube, demonstrating synthesis of haemoglobin from injected mRNA, and of 5S rRNA from injected DNA, as -
How the earliest life on Earth may have replicated itself - MRC…
https://www2.mrc-lmb.cam.ac.uk/how-the-earliest-life-on-earth-may-have-replicated-itself/16 May 2018: To test this theory of an ‘RNA world’, scientists have been trying to recreate a self-replicating RNA in the laboratory. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/16108
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/16108{"id":16108,"date":"2020-07-10T12:49:35","date_gmt":"2020-07-10T09:49:56","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?page_id=16108"},"modified":"2024-05-31T17:30:23","modified_gmt":"2024-05-31T16:30:23","slug":"blue-sky-collaboration","statu -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/13500
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/13500{"id":13500,"date":"2018-12-21T11:09:54","date_gmt":"2018-12-21T11:09:54","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?page_id=13500"},"modified":"2023-07-21T12:53:12","modified_gmt":"2023-07-21T11:53:12","slug":"lmb-365","status":"publish","t -
TRIM21 links antibody and T cell immunity to combat viral infection - …
https://www2.mrc-lmb.cam.ac.uk/trim21-links-antibody-and-t-cell-immunity-to-combat-viral-infection/4 Dec 2020: It has been known for many years that our immune system produces antibodies against viral nucleoproteins and measuring the presence of these antibodies has become a standard rapid diagnostic test to -
Over 50 LMB scientists showcase research at the Cambridge Science…
https://www2.mrc-lmb.cam.ac.uk/over-50-lmb-scientists-showcase-research-at-the-cambridge-science-festival/27 Mar 2014: test their detective skills with the stereomicroscope challenge. ... to test their scientific skills in their containment hood speed pipetting game. -
Discovery of the genetic basis of a rare immune disease - MRC…
https://www2.mrc-lmb.cam.ac.uk/discovery-of-the-genetic-basis-of-a-rare-immune-disease/22 Oct 2013: A simple genetic test can tell if the patient has the mutation or not. -
LMB showcases the beauty of the microscopic world at the Cambridge…
https://www2.mrc-lmb.cam.ac.uk/lmb-showcases-the-beauty-of-the-microscopic-world-at-the-cambridge-festival/31 Mar 2023: Participants could see their own cheek cells under the microscope and test their detective skills in an interactive game. -
From the scientist’s view: a conversation with… Buzz Baum - MRC…
https://www2.mrc-lmb.cam.ac.uk/life-at-the-lmb/profiles/from-the-scientists-view-a-conversation-with-buzz-baum/15 Dec 2023: Now, Buzz’s group works to further test this theory using archaeal cells as a model to study evolution. ... I spent years after that, trying to test the model directly. -
How flies use smell to determine the identity and position of other…
https://www2.mrc-lmb.cam.ac.uk/how-flies-use-smell-to-determine-the-identity-and-position-of-other-flies/25 May 2023: Using genetically engineered flies, the group were able to test the hypotheses they derived from their wiring map. -
Network control principles predict neuron function in the C. elegans…
https://www2.mrc-lmb.cam.ac.uk/network-control-principles-predict-neuron-function-c-elegans-connectome/19 Oct 2017: To test the predictions, Denise Walker in Bill’s group used a laser microbeam to specifically kill individual neurons predicted to be important for controllability, as well as some related neurons -
LMB showcases the diversity of science at the Cambridge Science…
https://www2.mrc-lmb.cam.ac.uk/lmb-showcases-the-diversity-of-science-at-the-cambridge-science-festival/28 Mar 2018: Visitors could view ‘mini-brains’ in a dish and find out how these brain organoids are used to study brain development, and then test their matching skills in the ‘Where is -
Atomic structure of chromosomal complex responsible for organising…
https://www2.mrc-lmb.cam.ac.uk/atomic-structure-of-chromosomal-complex-responsible-for-organising-dna-determined/4 Nov 2021: In order to test whether the mode of DNA binding revealed by cryo-EM also occurs in cells, Frank genetically engineered E. -
Refactoring the genetic code to create organisms protected by a…
https://www2.mrc-lmb.cam.ac.uk/refactoring-the-genetic-code-to-create-organisms-protected-by-a-genetic-firewall/24 Oct 2022: To test whether the newly engineered cells were resistant to viral infection, the team collaborated with George Salmond’s group in the University of Cambridge Department of Biochemistry. -
Christian Münch Receives British Neuroscience Association…
https://www2.mrc-lmb.cam.ac.uk/christian-munch-receives-british-neuroscience-association-postgraduate-award/15 Dec 2011: During his PhD work, Christian studied what causes aggregation of mutant SOD1 in the test tube and in cells. -
Understanding the protein modifications behind Trim-Away protein…
https://www2.mrc-lmb.cam.ac.uk/understanding-the-protein-modifications-behind-trim-away-protein-degradation-technology/17 Apr 2023: To directly test if TRIM21 N-terminal ubiquitination is required for TRIM21 function, Leo Kiss in collaboration with Jonas Weidenhausen in Irmgard Sinning’s lab at the University of Heidelberg developed -
Day of celebration as Her Majesty The Queen opens the new LMB…
https://www2.mrc-lmb.cam.ac.uk/day-of-celebration-as-her-majesty-the-queen-opens-the-new-lmb-building/23 May 2013: UK’s economic competitiveness. -
Liz Miller: Signed, sealed, delivered - protein trafficking in the…
https://www2.mrc-lmb.cam.ac.uk/liz-miller-signed-sealed-delivered-protein-trafficking-in-the-endoplasmic-reticulum/13 Oct 2020: Despite Liz having the security of tenure, she and Marcus started looking for other places to live and work, as the economic climate meant that it was unlikely that Marcus would -
Mesolens Microscopy (2009) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/research/technology-transfer/recent-technology-transfer-initiatives/mesolens-microscopy-2009/21 Jul 2023: A test centre for Mesoscopy has been set up in the University of Strathclyde, and commercial production of microscopes based on this technology is planned. -
Opening of LMB Containment Level 3 lab fast-tracked to help fight the …
https://www2.mrc-lmb.cam.ac.uk/opening-of-lmb-containment-level-3-lab-fast-tracked-to-help-fight-the-covid-19-pandemic/23 Oct 2020: I have also started working on a new project with Radu Aricescu and Jan Löwe to test new vaccine candidates. ... Our facility can be of use to pharmaceutical companies working on new treatment strategies and fast diagnostic tests and we are already in -
refmac keywords
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/refmac/refmac_keywords.html6 Oct 2014: refmac keywords (version 5.5.0026 and later). Please note that most of these keywords were in the previous versions also. Some of the keywords were implemented as user requests. The numbers inside the brackets (if present) after the keyword -
Advanced understanding of how suprachiasmatic nucleus regulates the…
https://www2.mrc-lmb.cam.ac.uk/advanced-understanding-of-how-suprachiasmatic-nucleus-regulates-the-bodys-circadian-rhythm/9 Sep 2021: These tests exposed how the signalling network across the SCN changes over day and night. -
HIV exploits a native cellular molecule to increase the stability of…
https://www2.mrc-lmb.cam.ac.uk/hiv-exploits-a-native-cellular-molecule-to-increase-the-stability-of-its-capsid/31 May 2018: Finally, Donna teamed up with Adolfo Saiardi to devise a way to test whether IP. -
Unravelling the replisome: how a molecular machine overcomes…
https://www2.mrc-lmb.cam.ac.uk/unravelling-the-replisome-how-a-molecular-machine-overcomes-obstacles-to-dna-replication/4 May 2020: on a section of DNA in a test tube, before solving the structure using electron cryo-microscopy (cryo-EM) and mass spectrometry.
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