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18 Aug 2015: The development of a direct replacement test can takemany years, so potential for ‘avoidance’ should always be explored. ... Bacterial tests for mutation are used to test almost all typesof chemical for mutagenicity.

30 Apr 2024: Motor behaviour and cognitive tests will place the mice shortly in an unfamiliar environment. ... To assess motor behaviour, we will perform tests such as Catwalk, Rotarod, and Grip strength and to assess cognitive behaviour, we will perform Barnes maze

30 Apr 2024: Hence, although individual elements of CVD can be modelled in a 'test tube' (e.g. ... Thus, when we use animal models this will be because we typically have several years worth of 'test tube' experiments that support the use of animal experiments for

8 Jan 2015: the administration of any substance or article to an animal for research purposes in accordance with an animal test certificate granted under the veterinary Medicines Regulations 2011. • ... www.nerc.ac.uk/publications/corporate/ethics.asp Natural

30 Apr 2024: The cost of mental health disorders to the UK in terms of social, economic and health factors is extremely high. ... As we are interested in adult behaviour, the majority of our behavioural tests will be conducted in adult animals.

18 Jun 2021: The project will inform the development, and test the feasibility of novel therapeutic strategies to treat heart failure. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

18 Sep 2015: Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes. December 2014. 44389_00 Cover 10mm spine.indd 1 15/12/2014 17:34. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for

30 Apr 2024: As we are interested in adult behaviour, the majority of our behavioural tests will be conducted in adult animals. ... We perform these manipulations to test the impact of early life stress on the behaviour of the offspring as adults.

30 Apr 2024: Downloaded: 9:17pm, 25 Apr 2024 Page 4 of 8. scientific tests have been developed for it which we could make use of to investigate in our study. ... Potential refinements include increased monitoring if test animals show earlier clinical signs or weight

30 Apr 2024: neurophysiological basis of visual cognition and memory will have far reaching social and economic implications. ... This test is important to allow animals to be directed into studies that they are most appropriate for.

19 Aug 2021: This project aims to improve our understanding of the cellular mechanisms that underlie IR injury and test the safety and efficacy of promising novel therapeutic agents. ... This project will generate academic outputs, new treatment products, and the

13 Sep 2021: The project will inform the development, and test the feasibility of novel therapeutic strategies to treat heart failure. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

30 Apr 2024: of cognitive and emotional symptoms of neuropsychiatric disorders will have far reaching social and economic implications. ... can move freely once in the test apparatus and (iii) are tested for less than 40 minutes.

13 Sep 2021: We therefore wish to test if defects of the mouse EIF2AK4 gene can also be worsened by lung inflammation. ... be shown, and some account of the tests of significance to be made and the treatment differences that are to be estimated).

30 Apr 2024: This project aims to improve our understanding of the cellular mechanisms that underlie ischaemia-reperfusion injury (tissue damage caused when blood supply returns to tissue) and test the safety and effectiveness ... This project will generate academic

30 Apr 2024: The exact set of behavioural tests will be used is dependent on the mouse model being investigated. ... Our assessment includes both non-regulated and regulated tests, most having no noticeable adverse effects.

30 Apr 2024: We expect to uncover a pathway to promote myelin regeneration, and test its therapeutic potential. ... tests, or labelling (with dyes or fluorescent markers) the central nervous system under non recovery anaesthesia.

13 Sep 2021: This is why we need to use living animals to understand the complexity of the disease process and test the potential effect of new treatments. ... We will continue to test other non-animal strategies with the aim to replace the use of animals.

30 Apr 2024: This will help reduce the vast burden of pregnancy-induced origins of cardiovascular disease, thereby having a major clinical, economic, and societal impact on cardiovascular health. ... It may be possible in future to extend some of the work by using

29 Apr 2024: Each of our experiments is designed on the back of a robust statistical approach that relies on state-of-the-art statistical tests and models. ... covariance, and associated post-hoc tests, dimensional analyses, such as multiple and factorial regressions,

13 Sep 2021: Hence, medical conditions of the oesophagus represent an important social and economic burden, with a significant proportion of our public health budget spent in treatments that are inefficient and, in most ... 4. Test experiments, called pilot

25 Sep 2015: number of such alternative methods. However, ‘alternative’ tests and models have yet to be. ... the animals, minimising the number of animals employed in each test, and avoiding.

14 May 2024: Researchers in the University’s Department of Surgery are using large animal models to understand why donated organs become damaged and unsuitable for transplantation, and to test promising new treatments.

14 May 2024: These are not the usual brand and therefore would usually need a new face fit test.

7 Dec 2022: The committee acknowledged that while in the past this test has been overstated as a model of depression, under the right circumstances, this test still has validity. ... A ban on any test would remove this conversation entirely which the committee

14 May 2024: mice to test the principal.

14 May 2024: The AWERB committee will be reviewing the letter sent to the Vice Chancellor from PETA regarding the use of the Forced Swim Test.

26 Sep 2012: Disease control Written assessment. Laboratory animal welfare Unit test. Scientific procedures Scientific procedures Written assessment. ... Learner: learners will be required to do less assignments and some more unit tests.

14 May 2024: Are the surgical skills already present within the team? Behavioural tests. •

14 May 2024: cage. had a meeting regarding the auto watering system and recent test results show that the new dosing?

17 Jan 2024: had a discussion with who said that there is a device that can be fitted to a tap to test for Legionella automatically.

7 Dec 2022: Specific refinements in regards to behavioural tests added to the Refinement section. • ... Further information in regards to specific tests planned. • Specific volumes need adding.

7 Dec 2022: Further information. around how the behavioral tests will be managed in regards to the rest time between each and if different types of tests used will be mixed. • ... the animals during your project?’ section. • The inclusion of limits and the

7 Dec 2022: Further information. around how the behavioral tests will be managed in regards to the rest time between each and if different types of tests used will be mixed. • ... the animals during your project?’ section. • The inclusion of limits and the

7 Dec 2022: The removal of specific tests from Appendix and the inclusion of these as a separate step in. ... Protocols and • Further information included in Protocols and in regards to specific tests planned. •

11 Jan 2023: A FOI has been requested for a swimming test but we don’t currently have any happening at the so we were able to supply a nil response.

7 Dec 2022: informed the committee that the had received FOI requests about use and authorisation of the Porsolt Forced Swim Test.

7 Dec 2022: Review the number of blood samples being taken during a Glucose Tolerance Test to ensure that the number is sufficient. •

7 Dec 2022:  Frequencies of specific tests planned added to the Part D: Project Plan.

30 Aug 2023: c) Amendment: The committee discussed the following:. • Further detail required in the Project Harms section in regards to specific tests planned and the impact on the animals. •

7 Dec 2022: could understand it. • The aim to test efficacy could be further clarified. •

7 Mar 2023: Further detail included in the Project Plan to explain why specific tests are the most appropriate. •

7 Dec 2022: Further information in regards to specific tests planned in Protocol 7. •

19 Aug 2021: Data will be published from the in vivo biocompatibility tests in the licence. ... Some animals are used in pilot studies to test the compatibility of new potentially therapeutic compounds.

7 Dec 2022: Page 2 of 3. • Suggest investigating whether the GTT test is as effective with the glucose administered by the more natural oral route and if so undertake a studu dosing by

7 Dec 2022: Further detail required around specific tests undertaken in Section 2.5. •

20 Aug 2021: The lowest numbers of animals will be used consistent with obtaining a reasonable estimate of experimental variability to test for meaningful results between treatment groups. ... We will only test drugs in animals, when we know they work with isolated

29 Apr 2024: Blood samples will be taken after each vaccination to test for the induction of immune responses. ... There are no non-animal alternatives to conclusively test the immunogenicity and protection of vaccines.

20 Aug 2021: We will then test these antibodies to see if they can be used as medicines. ... Aim 2 – Immunise these mice to make antibodies. Aim 3 – Test these antibodies in mouse models.

13 Sep 2021: Some animals in this project will be subjected to calorie restriction or exercise or behavioural tests, which are expected to cause no more than temporary stress until the animals have acclimatised. ... Whenever feasible and scientifically appropriate,