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29 Apr 2024: This includes engineering tests (testing devices on the bench), computer models, and cell culture tests. ... The experimenter can make use of this to test devices aimed to restore similar deficits in patients.

30 Apr 2024: In this study, we will test potential treatments for Pelizaeus-Merzbacher disease, which currently has no cure. ... Behavior test: Assessment of cognitive, sensory and motor coordination might be done for mice developing phenotypes.

29 Apr 2024: To develop and validate animal models that can further our understanding of basic mechanisms involved in immunological disease and enable us to test new therapeutic agents. ... goal by enabling us to test new therapeutic hypothesis in vivo relevant to

30 Apr 2024: These are useful to test sensing mechanisms with a number of different assays. ... In this model, we can test nutrients or hormones and measure a number of metrics relevant to brain function.

30 Apr 2024: What's the aim of this project? To fully test and understand how good platelets (blood cells that help stop bleeding) made from stem cells are at stopping bleeding. ... We are generating platelets from stem cells in the laboratory and need to test how

30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... the action of test agents, and well as the variability in replicating the disease.

30 Apr 2024: They will also identify test agents which are not suitable for further development. ... This expert regularly tests the tool against peer-reviewed power calculators and can adjust as necessary.

30 Apr 2024: These tests showed that the devices work well in recording nerve activity and helping to control how nerves work. ... For example, we do a lot of computer simulations, which helps us test fewer things in living animals.

30 Apr 2024: The knowledge gained will be used to develop and test of novel therapeutic interventions. ... Live animals are required to test in vivo therapies. Wherever possible, animals will be killed prior to tissue harvest.

29 Apr 2024: 4 or less). Followed by longer (e.g. 3, 6, 12 or 24 months), larger studies (less than 10 animals per test group at each time point).

30 Apr 2024: This licence will enable us to test new treatments in mice and rats and predict how much to use in these models. ... Pharmacokinetic studies are usually not hypothesis testing in a statistical sense, so we do not test for a significant difference in

30 Apr 2024: The majority of the data will be collected at the end of studies, where animals will be under deep terminal anaesthesia, in order to perform tests on how effective a test ... Giving a drug before injury can test its effect on bleeding and clot formation.

29 Apr 2024: This project will develop and test the safety and effectiveness of new vaccines against EHV induced disease. ... We typically use 7 animals per vaccine group, and we envisage we will test at least 2 candidate vaccines.

29 Apr 2024: What's the aim of this project? The aim of this project is to study how the immune system recognises cancer cells, and test the safety and effectiveness of drugs that ... The proposed project will allow a better understanding of how the immune system

30 Apr 2024: Typically such tests will be performed whilst agents that modify gut hormone release or act on gut hormone receptors are also administered, typically directly into the blood stream or into the ... Metabolic fitness test like these will typically involve

30 Apr 2024: Many of these behavioural tests will monitor the impact of pain on spontaneous behaviours, e.g. ... We also use non-interventional behavioural tests to measure the impact of pain conditions on an animal’s behaviour.

30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... body, as well as monitoring how the test agent performs in an intact biological system.

30 Apr 2024: Typically, a mouse will experience each of these above procedures. Some animals will undergo 1, 2 or sometimes 3 behavioural tests typically to test motor skills, anxiety and spatial navigation. ... 3. Methods (test substances, quarantine and monitoring,

30 Apr 2024: Why were they not suitable? It is not possible to entirely replace animal experiments for this project since it is important to test whether the principles identified in cell culture are

30 Apr 2024: This will allow us to change the signalling within particular cells and test the consequences on the mechanics and development of the whole organ. ... Why were they not suitable? It is not possible to entirely replace animal experiments for this project