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Developing new mulivalent recombinant vaccines platforms against…
https://www.ubs.admin.cam.ac.uk/system/files/public/developing_new_multivalent_recombinant_vaccines_platforms_against_infectious_diseases._non-technic_redacted.pdf29 Apr 2024: Blood samples will be taken after each vaccination to test for the induction of immune responses. ... There are no non-animal alternatives to conclusively test the immunogenicity and protection of vaccines. -
Development of novel therapeutics for pain (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_novel_therapeutics_for_pain_non-technical_summary_redacted.pdf30 Apr 2024: These tests are animal equivalents of the measures that are used to assess pain in humans. ... Most of these tests mirror the tests used clinically to assess pain in humans. -
Molecular mechanisms of tolerance and immunosuppression…
https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_tolerance_and_immunosuppression_non-technical_summary_redacted.pdf30 Apr 2024: Some mice will be used in experiments to test how the immune system responds to infections, inflammation and cancer. ... We considered using cells cultured and expanded in vitro to test whether certain molecular pathways have an important role in -
Development of nerve neuroprosthetic treatment
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_nerve_neuroprosthetic_treatments_non-technical_summary_redacted.pdf29 Apr 2024: This includes engineering tests (testing devices on the bench), computer models, and cell culture tests. ... The experimenter can make use of this to test devices aimed to restore similar deficits in patients. -
Nutrient sensing in the brain
https://www.ubs.admin.cam.ac.uk/system/files/public/nutrient_sensing_in_the_brain_non-technical_summary_redacted.pdf30 Apr 2024: These are useful to test sensing mechanisms with a number of different assays. ... In this model, we can test nutrients or hormones and measure a number of metrics relevant to brain function. -
The diversity of glia in health, development and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_diversity_of_glia_in_health_development_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: In this study, we will test potential treatments for Pelizaeus-Merzbacher disease, which currently has no cure. ... Behavior test: Assessment of cognitive, sensory and motor coordination might be done for mice developing phenotypes. -
Discovery and development of treatments for immunological diseases
https://www.ubs.admin.cam.ac.uk/system/files/public/discovery_and_development_of_treatments_for_immunological_diseases_non-technical_summary_redacted.pdf29 Apr 2024: To develop and validate animal models that can further our understanding of basic mechanisms involved in immunological disease and enable us to test new therapeutic agents. ... goal by enabling us to test new therapeutic hypothesis in vivo relevant to -
AWERB 3Rs Minutes 1st February 2023 Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_010223_redacted.pdf14 May 2024: RSVP at: https://www.the3rs.uni-tuebingen.de/en/event/3r-network-bw-webinar-9/ Papers and articles. • FDA no longer needs to require animal tests before human drug trials: FDA ... no longer needs to require animal tests before human drug trials | -
Platelets as a therapeutic tool
https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf30 Apr 2024: What's the aim of this project? To fully test and understand how good platelets (blood cells that help stop bleeding) made from stem cells are at stopping bleeding. ... We are generating platelets from stem cells in the laboratory and need to test how -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... the action of test agents, and well as the variability in replicating the disease.
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