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18 Jun 2021: The project will inform the development, and test the feasibility of novel therapeutic strategies to treat heart failure. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

19 Aug 2021: This project aims to improve our understanding of the cellular mechanisms that underlie IR injury and test the safety and efficacy of promising novel therapeutic agents. ... This project will generate academic outputs, new treatment products, and the

13 Sep 2021: The project will inform the development, and test the feasibility of novel therapeutic strategies to treat heart failure. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

13 Sep 2021: This is why we need to use living animals to understand the complexity of the disease process and test the potential effect of new treatments. ... We will continue to test other non-animal strategies with the aim to replace the use of animals.

13 Sep 2021: We therefore wish to test if defects of the mouse EIF2AK4 gene can also be worsened by lung inflammation. ... be shown, and some account of the tests of significance to be made and the treatment differences that are to be estimated).

13 Sep 2021: Hence, medical conditions of the oesophagus represent an important social and economic burden, with a significant proportion of our public health budget spent in treatments that are inefficient and, in most ... 4. Test experiments, called pilot

20 Aug 2021: The lowest numbers of animals will be used consistent with obtaining a reasonable estimate of experimental variability to test for meaningful results between treatment groups. ... We will only test drugs in animals, when we know they work with isolated

19 Aug 2021: Data will be published from the in vivo biocompatibility tests in the licence. ... Some animals are used in pilot studies to test the compatibility of new potentially therapeutic compounds.

13 Sep 2021: Some animals in this project will be subjected to calorie restriction or exercise or behavioural tests, which are expected to cause no more than temporary stress until the animals have acclimatised. ... Whenever feasible and scientifically appropriate,

20 Aug 2021: We will then test these antibodies to see if they can be used as medicines. ... Aim 2 – Immunise these mice to make antibodies. Aim 3 – Test these antibodies in mouse models.

18 Jun 2021: Particular cells from animals can be used to test the effect of drugs that could stop a disease. ... Mice will be removed from test scenarios if suffering from an adverse stress reaction, or other unexpected adverse effects.

18 Jun 2021: This way we can test their safety before then testing them in a mouse. ... We can then use these cells to perform experiments that test our ideas about how human cells respond to treatments without having to use cells from mice beforehand.

13 Sep 2021: We can test many combinations of cells and materials in culture this way in order to optimise how we regenerate damaged hearts. ... This strategy of testing engineered heart tissues in culture will again reduce the number of animals finally used in the

19 Aug 2021: Then, we will test whether the findings which result from the frog embryo experiments can be reproduced in higher animals, we use rodents because their neurobiology is similar to humans’.

13 Sep 2021: The number of animals that will undergo surgery will depend on the number of factors that we plan to test over the course of the project, but we envisage to use

18 Jun 2021: short periods up to 4 hours of water restriction before behavioural tests.

18 Jun 2021: of blood cancers, will test the effect of and suggest the likely benefit of earlier therapy. ... Examples of cell-targeting substances include drugs that have been shown to effectively inhibit tumour cell growth when tested "in a test-tube".

19 Aug 2021: We test the function of each genetic alteration before breeding them together. ... I don’t anticipate many refinements to transgenic methods as these are already very standardised and efficient, though where these are reported we will test and

13 Sep 2021: short periods up to 4 hours of water restriction before behavioural tests.

19 Aug 2021: Isolated animals tend to gain more weight than controls; they are more responsive to stimuli predicting reward (in specific behavioural tests) and are hyperactive as measured by specific behavioural tasks. ... least 5 days a week (in average), but they