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PPL number: | Granted: 02 Mar 21 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_regulation_of_fat_mass_and_its_association_with_metabolic_disease_redacted.pdf18 Jun 2021: Then towards the end of the study we might perform a glucose tolerance test using an intraperitoneal (this means into the abdominal cavity) glucose injection. ... Before the glucose and insulin tolerance tests mice will be fasted for up to 6 hours. -
PPL number: | Granted: 13 Jan 20 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_and_genetic_regulation_of_glial_development_and_function_nts_redacted.pdf19 Aug 2021: For example, phenotypes that we find in genetically altered embryos are confirmed by direct comparisons to control (un-altered) animals following the same test conditions. ... All of our experiments are designed to use only the number of animals needed -
PPL number: | Granted: 28 Jul 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/developing_anti-malarial_transmission_blocking_interventions_nts_redacted.pdf13 Sep 2021: Validate modes of action by modifying targets in transgenic parasites to specifically test these ideas. • ... Additionally, there is currently no alternative to animal species that can be used to test with regards to vaccine or drug sensitivity studies -
PPL number: | Granted: 19 Nov 19 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_of_transgenic_rodents_for_supply_of_tissues_to_the_client_nts_redacted.pdf20 Aug 2021: Fresh tissue is required by the client to run in vitro experiments to further the understanding of what causes disease and to test how drugs work. ... The client requires mice that have had their genes modified so that they can investigate what causes -
PPL number: | Granted: 12 Jul 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_pathogen_behaviour_in_relation_to_the_immunity_vaccines_and_antibiotic_treatment_nts_expires2022_redacted.pdf13 Sep 2021: Our research will study how and where the bacteria hide in the body to resist to vaccines and antibiotics and will test new innovative vaccines. -
PPL number: | Granted: 24 May 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_neuronal_excitation_and_neuroinflammation_nts_expires2023_redacted.pdf13 Sep 2021: prevent unnecessary suffering, we also use non-interventional behavioural tests to measure the impact of arthritis/colitis on an animal’s behaviour. -
PPL number: | Granted: 16 Jul 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/developing_therapeutic_drugs_for_cancer_including_the_establishment_of_tumour_models_nts_redacted.pdf13 Sep 2021: By doing so, we can test the activity of our new drug candidates on tumour growth in a more relevant way in a live animal. ... Our organization regularly uses a range of in vitro (taking place in a test tube or laboratory dish, outside a living animal) -
PPL number: | Granted: 19 Jun 18 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/genetically_engineered_mouse_models_of_cancer_nts_expires2023_redacted.pdf13 Sep 2021: To get a better understanding of the models we will test known anti-cancer drugs to determine how well the tumours respond to therapies. -
PPL number: | Granted: 16 Apr 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_of_mental_health_nts_expires2023_redacted.pdf13 Sep 2021: Thus, mental health disorders place a considerable burden on not only the affected individual, but also social and economic burdens on society. -
PPL number: | Granted: 08 Jul 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/regenerative_neuroimmunology_applied_to_progressive_multiple_sclerosis_research_nts_redacted.pdf13 Sep 2021: This will create new opportunities to test new therapies that can stop bad inflammation. ... After the identification of targets, we will then proceed to test our results in our mouse models of disease.
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