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18 Jun 2021: To test how effective vaccines are, pups will be infected with the viruses when adults. ... We will test all new medicines for treating virus infection in cells in the laboratory first, and only progress to animal experiments if positive results are

29 Apr 2024: A small subset of mice will undergo a blood test to check how much of a certain marker of interest they have (for example, a protein). ... The best, non-invasive way to monitor disease progression is to test the urine for protein.

13 Sep 2021: malfunctioning causes diseases and test whether they can be used to cure or treat disease. ... We also plan to test the effectiveness of new therapies based around ubiquitin ligase biology in tumour transplantation models.

29 Apr 2024: This will contribute to a reduction in the burden of developmental origins of heart disease, thereby having a positive clinical, economic and societal impact on health. ... The real ethical, biological and economic value of the avian relative to other

30 Apr 2024: Renal function can be assessed by tests performed in urine or blood collected from the animals. ... For example we use human kidney organoids to test drug activity in certain projects.

29 Apr 2024: We primarily use adult female mice, hamsters and guinea pigs to test our vaccines. ... There exists no cell-based model or less sentient model to test vaccines.

18 Jun 2021: 4. Test experiments, called pilot experiments, will be used to calculate the amount of a substance that we can safely inject into the animal. ... These test experiments will help us to work out how much this amount is but will only use a small number of

20 Aug 2021: The effects monitored in a similar way for example using a combination of the following: observation of general health and behaviour, regular blood tests, non-invasive imaging (e.g. ... Any models developed to test instruments or materials will take

18 Jun 2021: test interventions at early stages that decrease the severity of the disease and help the development of treatments. ... The same behavioural and gut function tests and endpoints will be applied as described above.

13 Sep 2021: mice, and; 4) in some cases, we will surgically transplant modified breast cells into the cleared breast tissue (Fatpad) of mice to test the effect of the certain genetic mutations on

30 Apr 2024: rodent models to test how well they remain detectable and/or functional over a defined period of time. ... The information gathered here will inform us which drug is best suited to take forward to test in the target animal species.

30 Apr 2024: endoscopy, bronchoscopy, MRI/CT/PET) and non imaging techniques (e.g. blood tests and functional assays).

18 Jun 2021: We will use this knowledge to develop and test new treatment strategies for pulmonary arterial hypertension and other related conditions. ... the length of the total process until we test the level of disease is 7 weeks.

18 Jun 2021: In the long-term (5-7 years), we expect that the findings of this study will result in the design of at least 1 human clinical trial to test the safety ... The purpose here will be to induce a disease, such as liver failure or diabetes, to test the

30 Apr 2024: licence. Furthermore, when possible, we will generate primary cell lines from mouse brains which will allow us to test some of our hypotheses in vitro prior to performing elaborate experiments that ... 1) We will perform pilot studies and in vitro tests

20 Aug 2021: We used computer-based mathematical descriptions of brain activity to make specific predictions that require fewer animals to test. ... For this reason, the majority of our behavioural tests involve positive reward rather than punishment, in order to

30 Apr 2024: This will create new opportunities to test new therapies that can stop inflammation, brain damage, and the subsequent development of neuropsychiatric disorders in the offspring. ... This has allowed us to test whether treatments will be (1) safe for

30 Apr 2024: After this she may undergo a glucose tolerance test (as described in point 5) prior to her being humanely killed and her tissues collected and stored for laboratory analyses. ... c) Glucose or insulin tolerance tests which require injection of either

20 Aug 2021: Pilot studies involve using a small number of mice to test the safety and efficacy of a method before using it on a larger number of mice.

19 Aug 2021: Over the same period, behavioural tests will be carried out once a week to test their ability to remain on a rotating cylinder and to cross a narrow beam. ... the expected number of studies to validate and test potential drugs for each project.