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30 Aug 2023: c) Amendment: The committee discussed the following:. • Further detail required in the Project Harms section in regards to specific tests planned and the impact on the animals. •

7 Mar 2023: Further detail included in the Project Plan to explain why specific tests are the most appropriate. •

7 Dec 2022: Further information in regards to specific tests planned in Protocol 7. •

7 Dec 2022: Page 2 of 3. • Suggest investigating whether the GTT test is as effective with the glucose administered by the more natural oral route and if so undertake a studu dosing by

19 Aug 2021: Data will be published from the in vivo biocompatibility tests in the licence. ... Some animals are used in pilot studies to test the compatibility of new potentially therapeutic compounds.

7 Dec 2022: Further detail required around specific tests undertaken in Section 2.5. •

20 Aug 2021: The lowest numbers of animals will be used consistent with obtaining a reasonable estimate of experimental variability to test for meaningful results between treatment groups. ... We will only test drugs in animals, when we know they work with isolated

20 Aug 2021: We will then test these antibodies to see if they can be used as medicines. ... Aim 2 – Immunise these mice to make antibodies. Aim 3 – Test these antibodies in mouse models.

29 Apr 2024: Blood samples will be taken after each vaccination to test for the induction of immune responses. ... There are no non-animal alternatives to conclusively test the immunogenicity and protection of vaccines.

13 Sep 2021: Some animals in this project will be subjected to calorie restriction or exercise or behavioural tests, which are expected to cause no more than temporary stress until the animals have acclimatised. ... Whenever feasible and scientifically appropriate,

30 Apr 2024: These tests are animal equivalents of the measures that are used to assess pain in humans. ... Most of these tests mirror the tests used clinically to assess pain in humans.

30 Apr 2024: Some mice will be used in experiments to test how the immune system responds to infections, inflammation and cancer. ... We considered using cells cultured and expanded in vitro to test whether certain molecular pathways have an important role in

29 Apr 2024: This includes engineering tests (testing devices on the bench), computer models, and cell culture tests. ... The experimenter can make use of this to test devices aimed to restore similar deficits in patients.

30 Apr 2024: In this study, we will test potential treatments for Pelizaeus-Merzbacher disease, which currently has no cure. ... Behavior test: Assessment of cognitive, sensory and motor coordination might be done for mice developing phenotypes.

29 Apr 2024: To develop and validate animal models that can further our understanding of basic mechanisms involved in immunological disease and enable us to test new therapeutic agents. ... goal by enabling us to test new therapeutic hypothesis in vivo relevant to

30 Apr 2024: These are useful to test sensing mechanisms with a number of different assays. ... In this model, we can test nutrients or hormones and measure a number of metrics relevant to brain function.

18 Jun 2021: Particular cells from animals can be used to test the effect of drugs that could stop a disease. ... Mice will be removed from test scenarios if suffering from an adverse stress reaction, or other unexpected adverse effects.

30 Apr 2024: What's the aim of this project? To fully test and understand how good platelets (blood cells that help stop bleeding) made from stem cells are at stopping bleeding. ... We are generating platelets from stem cells in the laboratory and need to test how

30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... the action of test agents, and well as the variability in replicating the disease.

30 Apr 2024: They will also identify test agents which are not suitable for further development. ... This expert regularly tests the tool against peer-reviewed power calculators and can adjust as necessary.