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Regulation of the mammalian reproductive axis
https://www.ubs.admin.cam.ac.uk/system/files/public/regulation_of_the_mammalian_reproductive_axis._non-technical_summary_redacted.pdf30 Apr 2024: We also want to test whether subcutaneous implants can be used to accurately monitor body temperature in the mice. -
PPL number: | Granted: 10 Apr 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/genetic_and_developmental_basis_of_morphological_variation_in_cichlid_fish_nts_expires2024_redacted.pdf13 Sep 2021: To identify genes responsible for coloration differences we will test if it is possible to interbreed different species with different colour patterns using in vitro fertilisation methods. ... Gene modifications are confirmed by collecting tissue -
PPL number: | Granted: 28 Jul 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/developing_anti-malarial_transmission_blocking_interventions_nts_redacted.pdf13 Sep 2021: Validate modes of action by modifying targets in transgenic parasites to specifically test these ideas. • ... Additionally, there is currently no alternative to animal species that can be used to test with regards to vaccine or drug sensitivity studies -
PPL number: | Granted: 13 Jan 20 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_and_genetic_regulation_of_glial_development_and_function_nts_redacted.pdf19 Aug 2021: For example, phenotypes that we find in genetically altered embryos are confirmed by direct comparisons to control (un-altered) animals following the same test conditions. ... All of our experiments are designed to use only the number of animals needed -
PPL number: | Granted: 02 Mar 21 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_regulation_of_fat_mass_and_its_association_with_metabolic_disease_redacted.pdf18 Jun 2021: Then towards the end of the study we might perform a glucose tolerance test using an intraperitoneal (this means into the abdominal cavity) glucose injection. ... Before the glucose and insulin tolerance tests mice will be fasted for up to 6 hours. -
PPL number: | Granted: 16 Apr 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_of_mental_health_nts_expires2023_redacted.pdf13 Sep 2021: Thus, mental health disorders place a considerable burden on not only the affected individual, but also social and economic burdens on society. -
PPL number: | Granted: 10 Jun 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_diseases_with_an_inflammatory_component_nts_expires2022_redacted.pdf13 Sep 2021: Because targets for these diseases are developing we are mostly focusing on helping the client with proof of concept studies, developing cell based assays to test their compounds in and then ... The techniques used for dosing with test agents and -
Development of Live Bacterial Therapeutics to treat diseases with…
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_live_bacterial_therapeutics_to_treat_diseases_with_intestinal_dysbiosis_non-technica_redacted.pdf29 Apr 2024: We aim to test the use of the mouse grimace scale for each protocol (https://nc3rs.org.uk/grimacescales). -
PPL number: | Granted: 19 Jun 18 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/genetically_engineered_mouse_models_of_cancer_nts_expires2023_redacted.pdf13 Sep 2021: To get a better understanding of the models we will test known anti-cancer drugs to determine how well the tumours respond to therapies. -
PPL number: | Granted: 24 May 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_neuronal_excitation_and_neuroinflammation_nts_expires2023_redacted.pdf13 Sep 2021: prevent unnecessary suffering, we also use non-interventional behavioural tests to measure the impact of arthritis/colitis on an animal’s behaviour. -
Environmental and placental contributions to pregnancy and life-long…
https://www.ubs.admin.cam.ac.uk/system/files/public/environmental_and_placental_contributions_to_pregnancy_and_life-long_health_non-technical_summary_redacted.pdf29 Apr 2024: World Health Organisation, General Medical Council, Royal College of Veterinary Surgeons) and pharmaceutical organisations who may develop policies, diagnostic tests and therapies to combat sub/infertility, pregnancy complications and. ... It also -
Potent monoclonal antibodies for biologics discovery (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/potent_monoclonal_antibodies_for_biologics_discovery_non-technical_summary_redacted.pdf30 Apr 2024: During the in vivo (performed in or on living animals) experiment, blood sample will be taken to test the generation of an antigen specific antibody response. -
PPL number: | Granted: 19 Nov 19 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_of_transgenic_rodents_for_supply_of_tissues_to_the_client_nts_redacted.pdf20 Aug 2021: Fresh tissue is required by the client to run in vitro experiments to further the understanding of what causes disease and to test how drugs work. ... The client requires mice that have had their genes modified so that they can investigate what causes -
PPL number: | Granted: 30 Jun 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/genes_and_mechanisms_involved_in_genome_regulation_nts_redacted.pdf13 Sep 2021: The number of animals that will undergo surgery will depend on the number of factors that we plan to test over the course of the project, but we envisage to use -
PPL number: | Granted: 16 Jul 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/developing_therapeutic_drugs_for_cancer_including_the_establishment_of_tumour_models_nts_redacted.pdf13 Sep 2021: By doing so, we can test the activity of our new drug candidates on tumour growth in a more relevant way in a live animal. ... Our organization regularly uses a range of in vitro (taking place in a test tube or laboratory dish, outside a living animal) -
PPL number: | Granted: 08 Jul 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/regenerative_neuroimmunology_applied_to_progressive_multiple_sclerosis_research_nts_redacted.pdf13 Sep 2021: This will create new opportunities to test new therapies that can stop bad inflammation. ... After the identification of targets, we will then proceed to test our results in our mouse models of disease. -
Pharmacological evaluation of imaging agents and development of…
https://www.ubs.admin.cam.ac.uk/system/files/public/pharmacological_evaluation_of_imaging_agents_and_development_of_imaging_applications_and_methods_no_redacted.pdf30 Apr 2024: We currently use several tests, depending on the kind of imaging agent, before proceeding to animal studies as follows. -
AWERB 3Rs Minutes 1st February 2023 Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_010223_redacted.pdf14 May 2024: RSVP at: https://www.the3rs.uni-tuebingen.de/en/event/3r-network-bw-webinar-9/ Papers and articles. • FDA no longer needs to require animal tests before human drug trials: FDA ... no longer needs to require animal tests before human drug trials | -
PPL number: | Granted: 12 Jul 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_pathogen_behaviour_in_relation_to_the_immunity_vaccines_and_antibiotic_treatment_nts_expires2022_redacted.pdf13 Sep 2021: Our research will study how and where the bacteria hide in the body to resist to vaccines and antibiotics and will test new innovative vaccines. -
PPL number: | Granted: 24 May 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_and_maintenance_of_genetically_altered_animals_for_regenerative_neuroimmunology_research_redacted_0.pdf18 Jun 2021: This way we can test their safety before then testing them in a mouse. ... We can then use these cells to perform experiments that test our ideas about how human cells respond to treatments without having to use cells from mice beforehand.
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