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PPL number: | Granted: 12 Feb 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/promoting_proliferation_in_non-regenerative_tissues_redacted.pdf18 Jun 2021: The project will inform the development, and test the feasibility of novel therapeutic strategies to treat heart failure. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies. -
PPL number: | Granted: 26 Nov 20 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_nts_redacted.pdf19 Aug 2021: This project aims to improve our understanding of the cellular mechanisms that underlie IR injury and test the safety and efficacy of promising novel therapeutic agents. ... This project will generate academic outputs, new treatment products, and the -
PPL number: | Granted: 12 Feb 21 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/promoting_proliferation_in_non-regenerative_tissues_nts_expires2026_redacted.pdf13 Sep 2021: The project will inform the development, and test the feasibility of novel therapeutic strategies to treat heart failure. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies. -
PPL number: | Granted: 06 Jul 21 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/the_role_of_the_immune_system_in_cardiovascular_disease_nts_expires2026_redacted.pdf13 Sep 2021: This is why we need to use living animals to understand the complexity of the disease process and test the potential effect of new treatments. ... We will continue to test other non-animal strategies with the aim to replace the use of animals. -
PPL number: | Granted: 09 Sep 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/the_integrated_stress_response_in_respiratory_disease_nts_redacted.pdf13 Sep 2021: We therefore wish to test if defects of the mouse EIF2AK4 gene can also be worsened by lung inflammation. ... be shown, and some account of the tests of significance to be made and the treatment differences that are to be estimated). -
PPL number: | Granted: 28 Jun 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/epithelial_stem_cell_behaviour_away_from_homeostasis_translational_relevance._nts_redacted.pdf13 Sep 2021: Hence, medical conditions of the oesophagus represent an important social and economic burden, with a significant proportion of our public health budget spent in treatments that are inefficient and, in most ... 4. Test experiments, called pilot Results that match 1 of 2 words
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PPL number: | Granted: 07 Aug 19 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/microglial_targets_in_brain_pathology_and_ageing_nts_redacted.pdf20 Aug 2021: The lowest numbers of animals will be used consistent with obtaining a reasonable estimate of experimental variability to test for meaningful results between treatment groups. ... We will only test drugs in animals, when we know they work with isolated -
PPL number: | Granted: 06 Jan 20 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/support_procedures_for_neural_repair_nts_redacted.pdf19 Aug 2021: Data will be published from the in vivo biocompatibility tests in the licence. ... Some animals are used in pilot studies to test the compatibility of new potentially therapeutic compounds. -
PPL number: | Granted: 03 Jul 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/regeneration_in_the_nervous_system_nts_expires2024_redacted.pdf13 Sep 2021: Some animals in this project will be subjected to calorie restriction or exercise or behavioural tests, which are expected to cause no more than temporary stress until the animals have acclimatised. ... Whenever feasible and scientifically appropriate, -
PPL number: | Granted: 06 Aug 19 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/mice_with_transgenic_immunoglobulin_loci_nts_redacted.pdf20 Aug 2021: We will then test these antibodies to see if they can be used as medicines. ... Aim 2 – Immunise these mice to make antibodies. Aim 3 – Test these antibodies in mouse models.
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