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7 Dec 2022: The removal of specific tests from Appendix and the inclusion of these as a separate step in. ... Protocols and • Further information included in Protocols and in regards to specific tests planned. •

11 Jan 2023: A FOI has been requested for a swimming test but we don’t currently have any happening at the so we were able to supply a nil response.

7 Dec 2022: informed the committee that the had received FOI requests about use and authorisation of the Porsolt Forced Swim Test.

7 Dec 2022: Review the number of blood samples being taken during a Glucose Tolerance Test to ensure that the number is sufficient. •

7 Dec 2022:  Frequencies of specific tests planned added to the Part D: Project Plan.

30 Aug 2023: c) Amendment: The committee discussed the following:. • Further detail required in the Project Harms section in regards to specific tests planned and the impact on the animals. •

7 Dec 2022: could understand it. • The aim to test efficacy could be further clarified. •

7 Mar 2023: Further detail included in the Project Plan to explain why specific tests are the most appropriate. •

7 Dec 2022: Further information in regards to specific tests planned in Protocol 7. •

19 Aug 2021: Data will be published from the in vivo biocompatibility tests in the licence. ... Some animals are used in pilot studies to test the compatibility of new potentially therapeutic compounds.

7 Dec 2022: Page 2 of 3. • Suggest investigating whether the GTT test is as effective with the glucose administered by the more natural oral route and if so undertake a studu dosing by

7 Dec 2022: Further detail required around specific tests undertaken in Section 2.5. •

20 Aug 2021: The lowest numbers of animals will be used consistent with obtaining a reasonable estimate of experimental variability to test for meaningful results between treatment groups. ... We will only test drugs in animals, when we know they work with isolated

29 Apr 2024: Blood samples will be taken after each vaccination to test for the induction of immune responses. ... There are no non-animal alternatives to conclusively test the immunogenicity and protection of vaccines.

20 Aug 2021: We will then test these antibodies to see if they can be used as medicines. ... Aim 2 – Immunise these mice to make antibodies. Aim 3 – Test these antibodies in mouse models.

13 Sep 2021: Some animals in this project will be subjected to calorie restriction or exercise or behavioural tests, which are expected to cause no more than temporary stress until the animals have acclimatised. ... Whenever feasible and scientifically appropriate,

30 Apr 2024: These tests are animal equivalents of the measures that are used to assess pain in humans. ... Most of these tests mirror the tests used clinically to assess pain in humans.

30 Apr 2024: Some mice will be used in experiments to test how the immune system responds to infections, inflammation and cancer. ... We considered using cells cultured and expanded in vitro to test whether certain molecular pathways have an important role in

29 Apr 2024: This includes engineering tests (testing devices on the bench), computer models, and cell culture tests. ... The experimenter can make use of this to test devices aimed to restore similar deficits in patients.

30 Apr 2024: In this study, we will test potential treatments for Pelizaeus-Merzbacher disease, which currently has no cure. ... Behavior test: Assessment of cognitive, sensory and motor coordination might be done for mice developing phenotypes.