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  2. doi:10.1016/j.jmb.2003.12.026

    https://supfam.mrc-lmb.cam.ac.uk/bioinformatics/people/julian_gough/publications/vogel_jmb_supra_2004.pdf
    30 Jan 2004: independent (methoddescribed in the legend to Table 2), resulting in a(one-sided) p-value for the test of the nullhypothesis. ... ij12 values, large-scale approximations. implicit in standard 2 £ 2 table association tests could not beapplied in most of

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