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Nutrient sensing in the brain
https://www.ubs.admin.cam.ac.uk/system/files/public/nutrient_sensing_in_the_brain_non-technical_summary_redacted.pdf30 Apr 2024: These are useful to test sensing mechanisms with a number of different assays. ... In this model, we can test nutrients or hormones and measure a number of metrics relevant to brain function. -
PPL number: | Granted: 17 Feb 21 | Expires: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/roles_for_genomic_instability_in_cancer_and_ageing_redacted.pdf18 Jun 2021: Particular cells from animals can be used to test the effect of drugs that could stop a disease. ... Mice will be removed from test scenarios if suffering from an adverse stress reaction, or other unexpected adverse effects. -
Platelets as a therapeutic tool
https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf30 Apr 2024: What's the aim of this project? To fully test and understand how good platelets (blood cells that help stop bleeding) made from stem cells are at stopping bleeding. ... We are generating platelets from stem cells in the laboratory and need to test how -
Provision of an outsourced drug discovery platform for the…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... the action of test agents, and well as the variability in replicating the disease. -
Provision of an outsourced drug discovery platform for metabolic and…
https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_metabolic_and_cardiovascular_diseases_non-te_redacted.pdf30 Apr 2024: They will also identify test agents which are not suitable for further development. ... This expert regularly tests the tool against peer-reviewed power calculators and can adjust as necessary. -
Models of mitochondrial diseases, pathogenesis and therapy
https://www.ubs.admin.cam.ac.uk/system/files/public/models_of_mitochondrial_diseases_pathogenesis_and_therapy_non-technical_summary_redacted.pdf30 Apr 2024: The knowledge gained will be used to develop and test of novel therapeutic interventions. ... Live animals are required to test in vivo therapies. Wherever possible, animals will be killed prior to tissue harvest. -
Exploring Bioelectronic Approaches to Nervous System Restoration in…
https://www.ubs.admin.cam.ac.uk/system/files/public/exploring_bioelectronic_approaches_to_nervous_system_restoration_in_large_animals_non-technical_sum_redacted.pdf30 Apr 2024: These tests showed that the devices work well in recording nerve activity and helping to control how nerves work. ... For example, we do a lot of computer simulations, which helps us test fewer things in living animals. -
Profiling of test agents in rodents in a drug discovery platform
https://www.ubs.admin.cam.ac.uk/system/files/public/profiling_of_test_agents_in_rodents_in_a_drug_discovery_platform_non-technical_summary_redacted.pdf30 Apr 2024: We will also study how the test agent distributes itself around the body. ... Dosing will usually be daily, but this may vary depending upon the test agent. -
Cartilage repair and replacement
https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf29 Apr 2024: 4 or less). Followed by longer (e.g. 3, 6, 12 or 24 months), larger studies (less than 10 animals per test group at each time point). -
PPL number: | Granted: 01 Dec 20 | Amended: ...
https://www.ubs.admin.cam.ac.uk/system/files/public/radiation_combinations_for_cancer_treatment_nts_redacted.pdf19 Aug 2021: What's the aim of this project? To test anti-cancer agents in combination with ionising radiation with the aim of improving current clinical therapies. ... Animal studies are only performed after every feasible test has been conducted on cancer cells in
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