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Embryonic origins of heart disease
https://www.ubs.admin.cam.ac.uk/system/files/public/embryonic_origins_of_heart_disease_non-technical_summary_redacted.pdf29 Apr 2024: This will contribute to a reduction in the burden of developmental origins of heart disease, thereby having a positive clinical, economic and societal impact on health. ... The real ethical, biological and economic value of the avian relative to other -
New treatments for renal and liver disease (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf30 Apr 2024: Renal function can be assessed by tests performed in urine or blood collected from the animals. ... For example we use human kidney organoids to test drug activity in certain projects. -
Vaccine development and fundamental reseach on viruses of medical…
https://www.ubs.admin.cam.ac.uk/system/files/public/vaccine_development_and_fundamental_research_on_viruses_of_medical_importance_non-technical_summary_redacted.pdf29 Apr 2024: We primarily use adult female mice, hamsters and guinea pigs to test our vaccines. ... There exists no cell-based model or less sentient model to test vaccines. -
Implantation of seeded scaffolds for tissue!organ development…
https://www.ubs.admin.cam.ac.uk/system/files/public/implantation_of_seeded_scaffolds_for_tissueorgan_development_non-technical_summary_redacted.pdf30 Apr 2024: endoscopy, bronchoscopy, MRI/CT/PET) and non imaging techniques (e.g. blood tests and functional assays). -
Generation and screening of companion animal therapeutics.…
https://www.ubs.admin.cam.ac.uk/system/files/public/generation_and_screening_of_companion_animal_therapeutics._non-technical_summary_redacted.pdf30 Apr 2024: rodent models to test how well they remain detectable and/or functional over a defined period of time. ... The information gathered here will inform us which drug is best suited to take forward to test in the target animal species. -
Mouse developmental genetics to study neurodevelopment and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/mouse_developmental_genetics_to_study_neurodevelopment_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: licence. Furthermore, when possible, we will generate primary cell lines from mouse brains which will allow us to test some of our hypotheses in vitro prior to performing elaborate experiments that ... 1) We will perform pilot studies and in vitro tests -
Interventions in pregnancy effects of obesity on maternal and…
https://www.ubs.admin.cam.ac.uk/system/files/public/interventions_in_pregnancy_effects_of_obesity_on_maternal_and_offspring_health_non-technical_summa_redacted.pdf30 Apr 2024: After this she may undergo a glucose tolerance test (as described in point 5) prior to her being humanely killed and her tissues collected and stored for laboratory analyses. ... c) Glucose or insulin tolerance tests which require injection of either -
Metabolic basis of microglia function in development (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf30 Apr 2024: This will create new opportunities to test new therapies that can stop inflammation, brain damage, and the subsequent development of neuropsychiatric disorders in the offspring. ... This has allowed us to test whether treatments will be (1) safe for -
Regulation of the mammalian reproductive axis
https://www.ubs.admin.cam.ac.uk/system/files/public/regulation_of_the_mammalian_reproductive_axis._non-technical_summary_redacted.pdf30 Apr 2024: We also want to test whether subcutaneous implants can be used to accurately monitor body temperature in the mice. -
Development of Live Bacterial Therapeutics to treat diseases with…
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_live_bacterial_therapeutics_to_treat_diseases_with_intestinal_dysbiosis_non-technica_redacted.pdf29 Apr 2024: We aim to test the use of the mouse grimace scale for each protocol (https://nc3rs.org.uk/grimacescales).
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